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Method for enhancing moisturizing effect of hyaluronic acid

A hyaluronic acid and efficacy technology, applied in the biological field, can solve the problems that the moisturizing effect of hyaluronic acid cannot be exerted to the best effect, the effective activity of hyaluronic acid cannot be maximized, and the moisturizing performance of hyaluronic acid is activated. Achieve the effect of protecting skin health, facilitating absorption, and powerful beauty effect

Inactive Publication Date: 2020-04-14
北京沐恩瑞生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main moisturizing function in this solution is still realized by the humectant, and the external moisturizing agent does not activate the moisturizing performance of hyaluronic acid itself, and cannot maximize the effective activity of hyaluronic acid
[0005] In view of the low transdermal absorption rate of the current existing cosmetic systems, resulting in the technical problem that the moisturizing effect of hyaluronic acid cannot be exerted to the best effect, it is necessary to provide a method that can promote and enhance the moisturizing function and absorption effect of hyaluronic acid itself. technical issues to be resolved

Method used

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  • Method for enhancing moisturizing effect of hyaluronic acid
  • Method for enhancing moisturizing effect of hyaluronic acid

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Embodiment 1

[0029] A method for enhancing the moisturizing effect of hyaluronic acid. Hyaluronic acid is formulated into composition A according to the following composition: 3 parts of butanediol, 2 parts of glycerin, 0.5 parts of small hyaluronic acid molecules, 0.3 parts of middle hyaluronic acid molecules, 0.3 parts of hyaluronic acid macromolecule, 2 parts of pentylene glycol, 3 parts of betaine, and the balance is water, and the total of the composition A is 100 parts;

[0030] The preparation method of described derivative liquid, comprises the following steps:

[0031] 1) Collect adipose tissue under sterile conditions and place it in a culture bottle;

[0032] 2) Rinse three times with a phosphate buffer solution equal to the volume of the adipose tissue to remove red blood cells;

[0033] 3) Add type I collagenase into the culture flask, let the type I collagenase act on the washed adipose tissue, and digest at 37°C for 35 minutes;

[0034] 4) Centrifuge the digested product i...

Embodiment 2

[0041] A method for enhancing the moisturizing effect of hyaluronic acid. Hyaluronic acid is formulated into composition A according to the following composition: 5 parts of butanediol, 4 parts of glycerin, 0.2 parts of small hyaluronic acid molecules, 0.1 parts of middle hyaluronic acid molecules, 0.2 parts of hyaluronic acid macromolecule, 2 parts of pentylene glycol, 1.5 parts of betaine, and the balance is water, and the total of the composition A is 100 parts;

[0042] The preparation method of described derivative liquid, comprises the following steps:

[0043] 1) Collect adipose tissue under sterile conditions and place it in a culture bottle;

[0044] 2) Rinse three times with a phosphate buffer solution equal to the volume of the adipose tissue to remove red blood cells;

[0045] 3) Add type I collagenase into the culture flask, let the type I collagenase act on the washed adipose tissue, and digest at 37°C for 40 minutes;

[0046]4) Centrifuge the digested product ...

Embodiment 3

[0053] A method for enhancing the moisturizing effect of hyaluronic acid. Hyaluronic acid is formulated into composition A according to the following composition: 3 parts of butanediol, 2 parts of glycerin, 0.5 parts of small hyaluronic acid molecules, 0.3 parts of middle hyaluronic acid molecules, 0.3 parts of hyaluronic acid macromolecule, 2 parts of pentylene glycol, 3 parts of betaine, and the balance is water, and the total of the composition A is 100 parts;

[0054] The preparation method of described derivative liquid, comprises the following steps:

[0055] 1) Collect adipose tissue under sterile conditions and place it in a culture bottle;

[0056] 2) Rinse three times with a phosphate buffer solution equal to the volume of the adipose tissue to remove red blood cells;

[0057] 3) Add type I collagenase into the culture flask, let the type I collagenase act on the washed adipose tissue, and digest at 37°C for 45 minutes;

[0058] 4) Centrifuge the digested product i...

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Abstract

The invention provides a method for enhancing the moisturizing effect of hyaluronic acid. The preparation method includes: preparing hyaluronic acid into a composition A according to the following composition of: 3-8 parts of butanediol, 2-6 parts of glycerin, 0.1-0.5 part of hyaluronic acid small molecules, 0.1-0.5 part of hyaluronic acid medium molecules, 0.1-0.5 part of hyaluronic acid macromolecules, 1-5 parts of pentanediol, 0.5-3 parts of betaine and the balance water. Preferably, the composition A is mixed with a derivative liquid. According to the invention, hyaluronic acid and adiposetissue-derived stromal cell conditioned culture supernatant are mixed, through the specific collocation relationship of the raw materials and the ratio of the composition, a synergistic effect of theraw materials can be achieved, and while being convenient to daub, the composition is more beneficial to skin absorption and has lasting moisturizing effect, is more beneficial to skin health protection, and has strong beautifying effect.

Description

technical field [0001] The invention relates to the field of biotechnology, and in particular discloses a method for enhancing the moisturizing effect of hyaluronic acid. Background technique [0002] Hyaluronic acid (HA), referred to as hyaluronic acid, is composed of N-acetylglucosamine and glucuronic acid disaccharide units repeatedly and alternately connected, and can exist freely in the body in the form of free chains. With its unique molecular structure and physical and chemical properties, hyaluronic acid is widely distributed in various parts of the human body. In the body, it has many important physiological functions such as regulating the permeability of blood vessel walls, regulating the diffusion and transport of proteins, water and electrolytes, and promoting wound healing. Function, at the same time, because hyaluronic acid has a special water-retaining effect, it is the most moisturizing substance found in nature so far, and is widely used in cosmetics. [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/99A61Q19/00C12N5/0775
CPCA61K8/735A61K8/99A61Q19/00C12N5/0667A61K2800/592A61K2800/805C12N2509/00
Inventor 金雪坤张兰英刘彦彦
Owner 北京沐恩瑞生物科技有限公司