Composite repair patch and preparation method thereof

Abstract

The invention relates to a composite repair patch and a preparation method thereof. The preparation method comprises the following steps: polycaprolactone is dissolved in dichloromethane to obtain a solution A, graphene oxide is added into dimethylformamide to obtain a solution B, and the solution B and the solution A are mixed to obtain a solution C; hexafluoroisopropanol and trifluoroethanol aremixed to form a mixed solution, chitosan is added into the mixed solution, the mixed solution is homogenized to obtain a homogenized mixed solution, and polycaprolactone powder is added to obtain a solution D; the solution C is spun to form an outer-layer film, and the solution D is attached to the outside of the outer-layer film to form an inner-layer film; a composite substrate is obtained; and1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide are dissolved into an alcohol solution, acetylcysteine is added to obtain a solution E, the composite substrate material is put into the cross-linking solution E, and the composite substrate material is taken out. The composite repair patch has the following beneficial effects: better mechanical strength is obtained; a good anti-adhesion effect is achieved; and the tissue repair capability is better.

Description

technical field [0001] The invention belongs to the technical field of medical repair patches, in particular to a tissue defect repair patch and a preparation method thereof. Background technique [0002] At present, there are various kinds of patches used for repairing abdominal wall defects, but each has its own defects in clinical application. Synthetic patches such as polypropylene and polytetrafluoroethylene are the most widely used materials in clinical practice. However, since these materials are not degradable, it is easy to cause complications such as abdominal organ adhesion, intestinal obstruction, intestinal fistula and chronic pain. [0003] Biological patches such as small intestinal submucosa and dermal acellular matrix have good biocompatibility, but their mechanical strength is insufficient, and the recurrence rate of long-term hernia is high. The use of autologous tissue flaps for repair is "removing the east wall to make up the west wall", which may caus...

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Problems solved by technology

[0005] In view of the above problems, the present invention provides a composite repair patch and its preparation method, which mainly solves the problems that the existing synthetic patch in the prior art is easy to cause adhesion of abdominal viscera, the mechanical strength of the biological patch is low, and the hernia recurrence rate is high.

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