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Application of erythrocyte and activated platelet membranes as carriers in preparation of thrombus treatment drugs

A technology for treating drugs and red blood cell membranes, which is applied in the field of medical thrombosis to achieve the effects of improving targeting, long blood half-life and good biocompatibility

Inactive Publication Date: 2020-04-21
INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the complex environment of the body, whether the nanoparticles coated with cell membranes can be enriched at the thrombus site and achieve a good thrombolytic effect remains to be further studied

Method used

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  • Application of erythrocyte and activated platelet membranes as carriers in preparation of thrombus treatment drugs
  • Application of erythrocyte and activated platelet membranes as carriers in preparation of thrombus treatment drugs
  • Application of erythrocyte and activated platelet membranes as carriers in preparation of thrombus treatment drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0049] Preparation of Thrombostatic Composition:

[0050] Required components: thrombolytic drugs, mesoporous silicon, erythrocyte membrane and activated platelet membrane.

[0051] Preparation:

[0052] The first step is to collect blood from the heart of the rat, and separate red blood cells and platelets by centrifugation, add hypotonic solution, put them in liquid nitrogen, and freeze and thaw repeatedly 5 times to remove the cell contents to obtain red blood cell membranes and activated platelet membranes .

[0053] The second step is to synthesize mesoporous silicon of about 140nm, mix mesoporous silicon and thrombolytic drugs according to a certain ratio, and stir at room temperature for 24 hours. Add erythrocyte membrane and activated platelet membrane and sonicate for 2 minutes. The mixed system was added to a dialysis bag with a molecular weight cut off of 3500 and dialyzed for 72 hours, and the camouflaged nano drug-loaded particles were collected as a thrombus i...

Embodiment 2

[0055] Preparation of Thrombostatic Composition:

[0056] Required components: thrombolytic drugs, mesoporous silicon, red blood cell membrane, activated platelet membrane and solvent saline.

[0057] Preparation:

[0058] It is obtained by dispersing the antithrombotic composition in Example 1 in physiological saline.

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Abstract

The invention discloses an application of erythrocyte and activated platelet membranes as carriers in preparation of thrombus treatment drugs, and relates to the technical field of medical thrombus treatment. The invention firstly provides an application of an erythrocyte membrane and an activated platelet membrane as carriers in preparation of thrombolytic drugs, and secondly, provides a composition for inhibiting and / or dissolving thrombus, comprising a thrombolytic drug, mesoporous silicon, an erythrocyte membrane, an activated platelet membrane and derivative membranes under various physiological and pathological conditions. Experimental research finds that a drug delivery system coated with an erythrocyte membrane and an activated platelet membrane has an obvious thrombolytic effect.The composition for inhibiting and / or dissolving thrombus is obtained by physically adsorbing thrombolytic drugs by utilizing mesoporous silicon, and coating the mesoporous silicon with an erythrocytemembrane and an activated platelet membrane. The thrombolytic drug is carried by the biological membranes, so that the targeting property and the enrichment degree of thrombus can be enhanced, the circulation time is remarkably prolonged, the bleeding risk is reduced, and a good thrombolytic effect is achieved.

Description

technical field [0001] The invention relates to the technical field of medical thrombosis treatment, in particular to the application of red blood cells and activated platelet cell membranes as carriers in the treatment of thrombosis. Background technique [0002] When the pathological process can no longer be regulated by the hemostatic regulation mechanism, a large amount of thrombin will be produced, thereby triggering the formation of thrombus. Thrombosis is an important factor in the development of cardiovascular diseases, such as arterial diseases such as myocardial infarction and stroke, and venous thromboembolic disorders, and the formation of thrombus leads to high morbidity and mortality. In addition, venous thrombosis is one of the leading causes of death in cancer patients. [0003] The formation of thrombus is related to many factors, including platelets, fibrin, collagen, tissue factor and thrombin. When the vessel wall is damaged or the endothelium is destro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/46A61K47/52A61K33/00A61P7/02
CPCA61K33/00A61K47/46A61K47/52A61P7/02
Inventor 陈奎王玉娇邢更妹
Owner INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
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