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Super-hydrophobic gel nano-coating for inhibiting bacterial adhesion, and preparation method thereof

A technology that inhibits bacteria and nano-coatings. It is applied in tooth protection coatings, pharmaceutical formulations, dental preparations, etc. It can solve problems such as unclear adhesion of coatings, damage to tooth tissue, and inability to apply clinically, so as to achieve good biological phase. Capacitance, caries prevention, and the effect of extensive promotion

Active Publication Date: 2020-04-24
温州医科大学附属口腔医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this experiment has the following disadvantages: 1. Phosphoric acid etching is performed on the tooth, which damages the tooth tissue; 2. The cost of heptadecafluorodecyltrimethoxysilane used in this experiment is relatively high, and the adhesion of the coating Unclear; 3. This experimental method cannot be easily and routinely applied to clinical practice

Method used

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  • Super-hydrophobic gel nano-coating for inhibiting bacterial adhesion, and preparation method thereof
  • Super-hydrophobic gel nano-coating for inhibiting bacterial adhesion, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1, a kind of preparation method of superhydrophobic gel nano-coating that inhibits bacterial adhesion

[0021] Include the following steps:

[0022] Step 1. Dissolve 5ml of tetraethoxysilane in 10ml of methanol, then add 7.5ml of 0.02 M NH 4 OH and 10ml of CH 3 The mixture of OH was stirred, 0.1M HCl was added dropwise to the mixture, the pH of the solution was adjusted to 5, 0.02g of dopamine hydrochloride was added, stirred for 3h, and NH 4 OH, adjust the pH of the solution to 8-9, and form brown opaque dopamine-silica gel after oxidation for 12 hours;

[0023] Step 2. Add 50ml of n-hexane and 7.5ml of 1,1,1,3,3,3-1,1,1,3,3,3-hexamethyldisilane to the dopamine-silica gel prepared in step 1 in a mixed water bath Heated at 70°C for 10h. After the reaction, filter and wash twice with n-propanol to obtain DSTM gel;

[0024] Step 3: Air-dry the DSTM gel prepared in Step 2 for 6 hours at 60°C, grind it into powder, dissolve it in ethanol, and vibrate ultraso...

Embodiment 2

[0025] Embodiment two DSTM gel spray surface performance detection

[0026] Contact angle detection test: the DSTM gel prepared in Example 1 was placed on the stage of the contact angle tester, and 2 μl of deionized water was dripped on the surface of the sample with a pipette. A picture of the droplet is captured using software and transferred to a computer for angle measurement. Measure 4 different points on each sample, read the value by ellipse method, the result is averaged, and its result is as shown in table 1:

[0027] Coating group CA=153.88° blank group CA=60.22°

Embodiment 3

[0028] Embodiment three DSTM gel spray adhesion performance detection

[0029] Get 30 bovine tooth enamel blocks (N=30), spray the DSTM gel prepared in Example 1, divide the enamel blocks into 6 groups, put the enamel blocks into artificial saliva and soak them for 2h, 4h, 6h, 8h, respectively. 10h, 12h. After the test, the contact angle and surface morphology were measured. The results of the adhesion test are shown in Table 2. After soaking in artificial saliva, the WCA of the coated tooth surface was not significantly different from that of the original experimental group.

[0030]

[0031]

[0032] Its result shows that the DSTM gel prepared by the present invention can closely adhere to the enamel surface, and its adhesiveness is strong, and can not have bigger impact on the adhesive performance and the hydrophobicity of DSTM gel under oral saliva environment , It can also maintain strong adhesion in the environment of oral saliva, so that it can be applied to cle...

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Abstract

The invention discloses a super-hydrophobic gel nano-coating for inhibiting bacterial adhesion, and a preparation method thereof. The super-hydrophobic gel nano-coating comprises, by weight, 5-10 parts of tetraethoxysilane, 5-10 parts of methanol, 5-20 parts of NH4OH, 5-10 parts of CH3OH, 0.1-0.01 part of dopamine hydrochloride, 50-100 parts of n-hexane and 5-10 parts of hexamethyldisilane. The preparation method comprises the following steps: preparing silica sol from tetraethoxysilane in an alkaline environment, adding dopamine to form a dopamine-silica gel, reacting the dopamine-silica gelwith hexamethyldisilane to form modified gel, drying the modified gel, and dissolving dried modified gel in ethanol to form a super-hydrophobic gel spray. The product has both surface super-hydrophobic property and matrix strong adhesion property, and also has good biocompatibility.

Description

technical field [0001] The invention relates to the technical field of oral materials, in particular to a superhydrophobic gel nanocoating for inhibiting bacterial adhesion and a preparation method thereof. Background technique [0002] Dental caries is one of the common diseases in dental clinics. It is a chronic bacterial infectious disease with a high prevalence rate and a wide range of damage. pathogenic factors. Dental plaque can form on the surface of various oral tissues, such as enamel surface, restoration, and implant surface. Therefore, effectively inhibiting the adhesion and colonization of oral pathogenic bacteria on the surface is the key to preventing dental caries. The most commonly used methods to prevent dental caries are fluoride, plaque control, and drug therapy. Remove the dental plaque that has formed on the tooth surface, but most individuals are difficult to maintain long-term plaque control standards; long-term use of broad-spectrum antimicrobials s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/896A61K6/891A61K6/70A61K6/15A61K6/20
Inventor 麻健丰黄盛斌金小婷史诗陈欢欢林婷婷
Owner 温州医科大学附属口腔医院
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