Antiseptic and anti-inflammatory wound repair dressing and preparation method thereof

A wound repair, bactericidal and anti-inflammatory technology, applied in pharmaceutical formulations, pharmaceutical sciences, absorbent pads, etc., can solve the problems of decreased stability of proanthocyanidins, inability to achieve application value, and decreased stability, to ensure anti-adhesion, The effect of promoting wound healing and avoiding secondary damage

Active Publication Date: 2020-04-28
优锐医药科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the stability of proanthocyanidins is affected by pH, which is relatively stable under low pH conditions. When the pH is greater than or equal to 6, its stability is significan

Method used

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  • Antiseptic and anti-inflammatory wound repair dressing and preparation method thereof
  • Antiseptic and anti-inflammatory wound repair dressing and preparation method thereof
  • Antiseptic and anti-inflammatory wound repair dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0037] Example 1

[0038] A bactericidal and anti-inflammatory wound repair dressing. The wound repair dressing is composed of a backing layer, a composite antibacterial layer and a hydrophobic skin layer. The backing layer is a polyurethane film; the composite antibacterial layer is black Fruit Lycium barbarum proanthocyanidins and allantoin are loaded on a hydrophobic porous film and are wrapped by a buffering nanofiber layer, the hydrophobic porous film is made of polylactic acid, and the buffering nanofiber layer is made of chitosan and hyaluronic acid. It is made of acid, honey and citric acid; the hydrophobic skin layer is made by mixing polylactic acid and chitosan.

[0039] A preparation method of a bactericidal and anti-inflammatory wound healing dressing specifically includes the following steps:

[0040] 1. Preparation of composite antibacterial layer:

[0041] S1-1: Dissolve polylactic acid in an acetic acid solution with a concentration of 4% to prepare a mixed solution ...

Example Embodiment

[0050] Example 2

[0051] A bactericidal and anti-inflammatory wound repair dressing. The wound repair dressing is composed of a backing layer, a composite antibacterial layer, and a hydrophobic skin layer. The backing layer is a polyurethane film; the composite antibacterial layer is made of grapes. Seed proanthocyanidins and allantoin are supported on a hydrophobic porous film and are wrapped by a buffering nanofiber layer, the hydrophobic porous film is made of polylactic acid, and the buffering nanofiber layer is made of chitosan, gelatin, honey And citric acid; the hydrophobic skin layer is made by mixing polylactic acid and chitosan.

[0052] A preparation method of a bactericidal and anti-inflammatory wound repair dressing specifically includes the following steps:

[0053] 1. Preparation of composite antibacterial layer:

[0054] S1-1: Dissolve polylactic acid in an acetic acid solution with a concentration of 5% to prepare mixed solution I. The concentration of mixed solutio...

Example Embodiment

[0063] Example 3

[0064] A bactericidal and anti-inflammatory wound repair dressing. The wound repair dressing is composed of a backing layer, a composite antibacterial layer and a hydrophobic skin layer. The backing layer is a polytetrafluoroethylene film; the composite antibacterial layer is made of peanut red Chlamydia cyanidin and allantoin are loaded on a hydrophobic porous film and are wrapped by a buffering nanofiber layer, the hydrophobic porous film is made of polycaprolactone, and the buffering nanofiber layer is made of chitosan, silk It is made of protein, gelatin, honey and citric acid; the hydrophobic skin-attachment layer is made by mixing polycaprolactone and chitosan.

[0065] A preparation method of a bactericidal and anti-inflammatory wound repair dressing specifically includes the following steps:

[0066] 1. Preparation of composite antibacterial layer:

[0067] S1-1: Dissolve polycaprolactone in an acetic acid solution with a concentration of 6% to prepare a mi...

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Abstract

The invention provides an antiseptic and anti-inflammatory wound repair dressing. The antiseptic and anti-inflammatory wound repair dressing comprises a backing layer, a composite antibacterial layerand a hydrophobic skin clinging layer, wherein the backing layer is a film which is prepared from a biodegradable polymer material, procyanidine and allantoin are loaded on a hydrophobic porous film,and the loading hydrophobic porous film is wrapped by a buffering nanofiber layer so as to prepare the composite antibacterial layer, and the buffering nanofiber layer is prepared from honey, citric acid and a hydrophilic polymer material; and the hydrophobic skin clinging layer is prepared through mixing one of a hydrophobic material polylactic acid and polycaprolactone with chitosan. The invention also provides a preparation method of the antiseptic and anti-inflammatory wound repair dressing. Not only can the prepared antiseptic and anti-inflammatory wound repair dressing be degraded and absorbed in vivo so as to achieve an anti-inflammatory and antibacterial effect, but also the stability and slow release of the procyanidine and allantoin in the wound repair dressing can be ensured, sothat the application scope of the procyanidine and allantoin is expanded.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a bactericidal and anti-inflammatory wound repair dressing and a preparation method thereof. Background technique [0002] The skin has physiological functions such as sensation, secretion, excretion, and temperature regulation. However, it is inevitable that in life, diseases such as skin ulcers will be caused by trauma, burns, scalds, or human lesions, which will lead to skin defects. Bacterial infection is one of the main factors affecting skin wound healing. A large number of inflammatory factors, proteases and free radicals contained in wound exudate will slow down the speed of wound healing. Therefore, the development of wound repair methods and repair materials has always been research hotspot. [0003] Wound healing can be divided into three phases: inflammation phase, fibrous tissue proliferation phase, and scar formation and repair phase. Studies have shown that th...

Claims

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Application Information

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IPC IPC(8): A61L15/40A61L15/20A61L15/26A61L15/28A61L15/24A61L15/42A61L15/44A61L15/46A61L15/50A61L15/64
CPCA61L15/20A61L15/24A61L15/26A61L15/28A61L15/40A61L15/42A61L15/425A61L15/44A61L15/46A61L15/50A61L15/64A61L2300/30A61L2300/404A61L2300/41A61L2300/412A61L2300/602A61L2400/04A61L2400/12C08L67/04C08L5/08C08L27/18C08L75/04
Inventor 张正男段书霞韩涵付迎坤孙海鹏石沛龙崔彬彬邵蕊娜韩修恒田崇周静郝明严子跃佘开江姬鹏远王喜卫段晓堂
Owner 优锐医药科技(上海)有限公司
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