Antiseptic and anti-inflammatory wound repair dressing and preparation method thereof

Abstract

The invention provides an antiseptic and anti-inflammatory wound repair dressing. The antiseptic and anti-inflammatory wound repair dressing comprises a backing layer, a composite antibacterial layerand a hydrophobic skin clinging layer, wherein the backing layer is a film which is prepared from a biodegradable polymer material, procyanidine and allantoin are loaded on a hydrophobic porous film,and the loading hydrophobic porous film is wrapped by a buffering nanofiber layer so as to prepare the composite antibacterial layer, and the buffering nanofiber layer is prepared from honey, citric acid and a hydrophilic polymer material; and the hydrophobic skin clinging layer is prepared through mixing one of a hydrophobic material polylactic acid and polycaprolactone with chitosan. The invention also provides a preparation method of the antiseptic and anti-inflammatory wound repair dressing. Not only can the prepared antiseptic and anti-inflammatory wound repair dressing be degraded and absorbed in vivo so as to achieve an anti-inflammatory and antibacterial effect, but also the stability and slow release of the procyanidine and allantoin in the wound repair dressing can be ensured, sothat the application scope of the procyanidine and allantoin is expanded.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a bactericidal and anti-inflammatory wound repair dressing and a preparation method thereof. Background technique [0002] The skin has physiological functions such as sensation, secretion, excretion, and temperature regulation. However, it is inevitable that in life, diseases such as skin ulcers will be caused by trauma, burns, scalds, or human lesions, which will lead to skin defects. Bacterial infection is one of the main factors affecting skin wound healing. A large number of inflammatory factors, proteases and free radicals contained in wound exudate will slow down the speed of wound healing. Therefore, the development of wound repair methods and repair materials has always been research hotspot. [0003] Wound healing can be divided into three phases: inflammation phase, fibrous tissue proliferation phase, and scar formation and repair phase. Studies have shown that th...

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Problems solved by technology

However, the stability of proanthocyanidins is affected by pH, which is relatively stable under low pH conditions. When the pH is greater than or equal to 6, its stability is significantly reduced, and the pH of the inflammatory phase of wound healing is greater than 7, which will cause the stability of proanthocyanidins to decline rapidly. to ideal application value

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