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Production process of high-activity small peptide chelated magnesium

A technology of small peptide chelation and production process, applied in the fields of peptide preparation, peptide, organic chemistry, etc., can solve the problems of low absorption and utilization rate, and achieve the effects of high production efficiency, low cost and simple process flow

Inactive Publication Date: 2020-04-28
陈石良
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the common magnesium supplements on the market are mainly inorganic magnesium. In the process of digestion and absorption, inorganic magnesium ions are easily affected by phytic acid, amino acids, cellulose, sugar complexes, vitamins, and unsaturated fatty acids in the feed, resulting in absorption and utilization. low rate

Method used

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  • Production process of high-activity small peptide chelated magnesium
  • Production process of high-activity small peptide chelated magnesium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Blood cell solution preparation: collect 1000L of fresh pig blood that has been anticoagulated, and use a tubular centrifuge to continuously centrifuge to obtain 455L of blood cell solution and 545L of plasma solution, collect the blood cell solution, and spray dry the plasma solution to make plasma protein powder;

[0023] (2) Hemolysis: pump the blood cell solution into the reaction tank, add 450L of deionized water, and stir continuously for 60 minutes to break the blood cells. The stirring speed is 30r / min to prepare 900L of hemolysis;

[0024] (3) Enzymolysis: Heating the hemolyzate to 50°C with continuous stirring, adjusting the pH value to 8.5 with NaOH solution, then adding protease at 1.2% of the weight of the blood cell solution, stirring continuously, and detecting the enzymolysis solution at intervals of one hour pH value, when the pH value drops below 8.5, adjust the pH value to 8.5 with alkali supplementation solution, heat the enzymolysis solution for ...

Embodiment 2

[0030] (1) Preparation of blood cells: collect 1000L of fresh pig blood that has been anticoagulated, and use a tubular centrifuge to continuously centrifuge to obtain 430L of blood cells and 570L of plasma, collect the blood cells, and spray dry the plasma to make plasma protein powder;

[0031] (2) Hemolysis: pump the blood cell solution into the reaction tank, add 430L of deionized water, and stir continuously for 60 minutes to break the blood cells. The stirring speed is 30r / min to prepare 850L of hemolysis;

[0032] (3) Enzymolysis: Heat the hemolyzate to 55°C with continuous stirring, adjust its pH value to 8.2 with NaOH solution, then add protease at 2% of the weight of the blood cell solution, keep stirring, and check the enzymolysis solution at intervals of one hour PH value, when the pH value drops below 8.2, adjust the pH value to 8.2 with alkali supplementation solution, keep the enzymatic hydrolysis for 4 hours, heat the enzymatic hydrolysis solution to 85°C to ina...

Embodiment 3

[0038] (1) Preparation of blood cells: collect 1000L of fresh pig blood that has been anticoagulated, and use a tubular centrifuge to continuously centrifuge to obtain 410L of blood cells and 590L of plasma, collect the blood cells, and spray-dry the plasma to make plasma protein powder;

[0039] (2) Hemolysis: pump the blood cell solution into the reaction tank, add 400L of deionized water, and stir continuously for 60 minutes to break the blood cells. The stirring speed is 30r / min to prepare 800L of hemolysis;

[0040] (3) Enzymolysis: Heating the hemolyzate to 52°C with continuous stirring, adjusting the pH value to 8.0 with NaOH solution, then adding 1.5% protease by weight of the blood cell solution, stirring constantly, and detecting the enzymatic hydrolyzate at intervals of one hour pH value, when the pH value drops below 8.0, adjust the pH value to 8.0 with alkali supplementation solution, heat the enzymolysis solution for 5 hours, heat the enzymolysis solution to 85°C ...

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Abstract

The invention relates to a production process of high-activity small peptide chelated magnesium. The production process mainly comprises the following steps: blood cell liquid preparation, hemolysis,enzymolysis, centrifugation, ultrafiltration, chelation and spray drying, thus obtaining the small peptide chelated magnesium. According to the invention, pig blood which is low in price and wide in source serves as a peptide source, inorganic magnesium salt serves as a magnesium source, the magnesium element and the protein peptide are chelated, the technological process is simple, the cost is low, and the production process is suitable for large-scale industrial production. The prepared product is high in small molecular peptide content and high in magnesium ion chelating rate, and is a novel efficient feed additive.

Description

technical field [0001] The invention relates to a preparation method of organic constant elements, in particular to a production process of highly active small peptide chelated magnesium. Background technique [0002] Magnesium is an essential macroelement for animal bodies and an important source of various enzymes in the body. Magnesium deficiency can lead to anorexia, growth retardation, hyperexcitability, spasms and muscle twitching in animals. [0003] At present, the common magnesium supplements on the market are mainly inorganic magnesium. In the process of digestion and absorption, inorganic magnesium ions are easily affected by phytic acid, amino acids, cellulose, sugar complexes, vitamins, and unsaturated fatty acids in the feed, resulting in absorption and utilization. low rate. Studies have shown that organic magnesium has a higher bioavailability than inorganic magnesium, and it can significantly promote the growth, reproduction, health and feed conversion rat...

Claims

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Application Information

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IPC IPC(8): C12P21/06C07K1/34C07K1/107C07K1/14
CPCC07K1/107C07K1/14C07K1/34C12P21/06
Inventor 陈石良
Owner 陈石良
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