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Monoclonal antibody pharmaceutical wastewater treatment method

A monoclonal antibody and pharmaceutical wastewater technology, applied in water/sewage treatment, natural water treatment, neutralized water/sewage treatment, etc., can solve the problems of wastewater treatment instability, large water volume fluctuations, high SS concentration, etc., to reduce Organic and insoluble components, stable effluent quality, improved biodegradation effect

Pending Publication Date: 2020-05-01
广州中科建禹环保有限公司
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Problems solved by technology

[0003] The ingredients for the preparation of monoclonal antibody drugs mainly include tricyclic urea compounds, pyridophthaloin ketone compounds, dihydrodiaza*carbazolones, 5-amino-4-carbamoyl-pyrazole compounds, etc. Therefore, the wastewater produced by monoclonal antibody drugs has a complex composition, many types of organic pollutants, a low ratio of BOD to COD and large fluctuations, a high concentration of SS, and large fluctuations in water volume.
At present, the commonly used methods for treating pharmaceutical wastewater include physical and chemical methods, chemical methods, biochemical methods, and a combination of multiple processes, but they face problems such as large fluctuations in water quality, poor biochemical properties, and high operating costs.
[0004] Patent CN103739138A discloses a treatment process for wastewater from the production of Chinese medicinal pieces, which discloses the use of USAB reaction towers and SBR pools to treat wastewater. However, the USAB reaction tower will have high energy consumption of the reflux pump, which is relatively prone to the phenomenon of running sludge. The SBR pool For intermittent operation, there is instability in wastewater treatment

Method used

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Experimental program
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Effect test

Embodiment

[0033] Take 50L of production wastewater from a monoclonal antibody pharmaceutical factory, and divide the wastewater into 5 batches, each batch is 100mL, and test the wastewater quality respectively. The average COD is 1000-1500mg / L, and the BOD is 800-1000mg / L. NH 3 -N is 100-120mg / L, SS is 200-350mg / L, and pH is 6-9. The results are shown in Table 1.

[0034] A. Wastewater pretreatment:

[0035] 1) Impurity removal: pass 50L of waste water through the grid well, and remove large and floating pollutants in the wastewater under the action of the grid;

[0036] 2) Regulating water quality: Waste water enters the regulating pool, and the waste water stays in the regulating pool for 10-13 hours to make the water quality more balanced and reduce the impact of sudden changes in water quality on the biochemical system;

[0037] 3) Adjust the pH value of the water: Lift the wastewater to the pH adjustment tank through the lifting pump, and adjust the wastewater to 8-9 by adding a ...

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Abstract

The invention belongs to the technical field of pharmaceutical wastewater treatment, and particularly relates to a monoclonal antibody pharmaceutical wastewater treatment method. The method comprises:A, wastewater pretreatment: removing SS pollutants in wastewater, reducing COD and BOD pollutants, and removing precipitation impurities; B, anaerobic hydrolytic acidification: carrying out hydrolytic acidification reaction on the wastewater without the precipitate pollutants by adopting bacterial enzymes under an anaerobic condition to remove residual COD and BOD pollutants; C, aerobic decomposition: removing pollutants in the wastewater subjected to hydrolytic acidification under the action of aeration and microorganisms; D, MBR filtration treatment; and E, disinfection treatment. By adopting a wastewater treatment process of 'pretreatment+secondary biochemistry+MBR filtration', the MBR tank is arranged at the tail end to further remove organic matters and biological residues in the wastewater, and compared with an SBR tank, the MBR tank operates continuously, so that the concentration of sludge obtained by treating the wastewater is higher, and the amount of discharged sludge is relatively small.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical wastewater treatment, and in particular relates to a treatment method for monoclonal antibody pharmaceutical wastewater. Background technique [0002] The wastewater produced by the pharmaceutical industry is one of the most difficult-to-treat high-concentration organic wastewater at home and abroad, and it is also one of the most polluted and most difficult-to-treat industrial wastewater in China. [0003] The ingredients for the preparation of monoclonal antibody drugs mainly include tricyclic urea compounds, pyridophthaloin ketone compounds, dihydrodiaza*carbazolones, 5-amino-4-carbamoyl-pyrazole compounds, etc. Therefore, the wastewater produced by monoclonal antibody drugs has a complex composition, many types of organic pollutants, a low ratio of BOD to COD and large fluctuations, a high concentration of SS, and large fluctuations in water volume. At present, the commonly used method...

Claims

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Application Information

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IPC IPC(8): C02F9/14C02F11/122C02F101/16C02F103/34
CPCC02F1/001C02F1/50C02F1/5236C02F1/56C02F1/66C02F3/30C02F9/00C02F11/122C02F2001/007C02F2101/16C02F2103/343C02F2303/04
Inventor 徐坤郑基炜周秀霞康兆雨
Owner 广州中科建禹环保有限公司
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