Metformin hydrochloride controlled-release tablet

A technology of metformin hydrochloride controlled-release tablets and metformin hydrochloride, which is applied in the direction of medical preparations, coatings, and pill delivery of non-active ingredients, which can solve the problems of taking 2 or 3 times a day and short half-life, so as to increase compliance , Reduce production costs, reduce the effect of treatment costs
CN111110648AInactive Publication Date: 2020-05-08XINFA PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
XINFA PHARMA
Publication Date
2020-05-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses a metformin hydrochloride controlled-release tablet. The metformin hydrochloride controlled-release tablet comprises a blank pill core, a drug-loading layer and a controlled-release film layer. The metformin hydrochloride controlled-release tablet is characterized in that the blank pill core is composed of one or more of microcrystalline cellulose, lactose and a sucrose pill core, the drug-loading layer comprises metformin hydrochloride, a filler, a binder and a lubricant, and the controlled-release film layer comprises a controlled-release material and a pore-forming agent. Advantages are that the metformin hydrochloride controlled-release tablet reduces the number of daily medication by patients with type 2 diabetes by changing medication from 2 or 3 timesa day to once a day, can improve bioavailability, also increases patient compliance, also reduces production cost, reduces patient treatment cost, and reduces national medical insurance support and financial burden from 10 yuan per tablet to 0.3 yuan per tablet.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to metformin hydrochloride controlled-release tablets and a preparation method thereof. Background technique

[0002] The chemical name of metformin (1,1-dimethylbiguanide) is commonly used as a drug and its hydrochloride is a white crystal or crystalline powder; it is odorless. Soluble in water, soluble in methanol, slightly soluble in ethanol, insoluble in chloroform, acetonitrile or ether. The brand name of the original metformin drug is "Gehuazhi", which is developed and produced by Bristol-Myers Squibb. Metformin hydrochloride is a biguanide hypoglycemic drug. It is used for type 2 diabetic patients who are not satisfied with simple diet control, especially obese and hyperinsulinemia patients. This drug not only has hypoglycemic effect, but also may reduce weight. and the effects of hyperinsulinemia. It can be effective for some patients with poor curat...

Claims

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