Iridium complex constructed based on 8-hydroxyquinoline derivative and 1-phenylpyrazole iridium dimer as well as synthesis method and application of iridium complex

A synthesis method and technology of complexes, applied in the field of medicine, can solve the problems of limited therapeutic effect and long-term use, neurotoxicity and bone marrow suppression, toxic and side effects, etc.
CN111116667AActive Publication Date: 2020-05-08煌途医药(无锡)有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
煌途医药(无锡)有限公司
Publication Date
2020-05-08

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Abstract

The invention discloses an iridium complex constructed based on a 8-hydroxyquinoline derivative and a 1-phenylpyrazole iridium dimer as well as a synthesis method and application of the iridium complex. The synthesis method of the iridium complex comprises the following steps: putting the 1-phenylpyrazole iridium dimer and the 8-hydroxyquinoline derivative into an organic solvent, and reacting under a heating or non-heating condition to obtain the corresponding target complex. A test result shows that the complex has remarkable biological activity (the activity is remarkably higher than that of ligand and cisplatin the complex) on cervical cancer and ovarian cancer cells, and meanwhile, the toxicity of the complex on human normal hepatocytes is extremely low (IC50 is greater than 80 [mu] M); on the other hand, the complex disclosed by the invention can also be used for fluorescence localization in tumor cells, and can be developed into a targeting anti-cancer drug for fluorescence localization targeting mitochondria.
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Description

technical field

[0001] The invention relates to an iridium complex constructed on the basis of 8-hydroxyquinoline derivatives and 1-phenylpyrazole iridium dimer and its synthesis method and application, belonging to the technical field of medicine. Background technique

[0002] Cancer is one of the most serious malignant diseases threatening human life and health. At present, more than three million people die of cancer every year in our country, which has seriously threatened the life and health of our people. Platinum complexes such as cisplatin are currently one of the most widely used chemotherapeutic drugs and one of the first-choice drugs for the treatment of many cancers (Lippard, S.J.; et al. Chem. Sci., 2015, 6, 1189–1193.). However, the extensive use of platinum-based drugs such as cisplatin in clinical practice can easily lead to drug resistance and severe side effects such as nephrotoxicity, neurotoxicity and bone marrow suppression, which greatly limit their th...

Claims

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