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Preparation method and applications for polydopamine coated mesoporous silica/elemene composite nanoparticle preparation

A technology of mesoporous silica and polydopamine, applied in the field of preparation and application of biomedical materials, to achieve the effect of good UV absorption and good sustained release

Pending Publication Date: 2020-05-12
HANGZHOU NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, combining polydopamine with nanoparticles to construct a mesoporous silica drug-loading system (PDA / MSN-ELE) for tumor-targeted delivery and pH-responsive materials is expected to achieve the purpose of tumor penetration and directional sustained release. Currently, PDA / MSN-ELE MSN-ELE composite nanomedicine and its application in the field of tumor treatment have not been reported yet

Method used

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  • Preparation method and applications for polydopamine coated mesoporous silica/elemene composite nanoparticle preparation
  • Preparation method and applications for polydopamine coated mesoporous silica/elemene composite nanoparticle preparation
  • Preparation method and applications for polydopamine coated mesoporous silica/elemene composite nanoparticle preparation

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Experimental program
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Effect test

Embodiment 1

[0027] This embodiment provides a polydopamine-coated mesoporous silica / elemene nanoparticle preparation and its preparation and application, as follows:

[0028] (1) Put 0.1g elemene and 10ml absolute ethanol in a conical flask, seal it, and ultrasonically disperse it for 5 minutes;

[0029] (2) Put 0.1g of mesoporous silica and 10ml of absolute ethanol in a Erlenmeyer flask and seal it, ultrasonically disperse for 15 minutes, and dissolve with magnetic stirring at 500 r / min at room temperature for 10 minutes. Slowly add the mixed solution of elemene and ethanol in step (1) to the solution in step b, and stir for 20-30 minutes at a speed of 500 r / min; after the dropwise addition is completed, continue stirring for 4 hours, centrifuged for 3 minutes, and the product was freeze-dried;

[0030] (3) Put 0.05g of mesoporous silica / elemene in step (2) and 10ml of deionized water into a conical flask, seal it, and ultrasonically disperse it for 5 minutes;

[0031] (4) Add the aque...

Embodiment 2

[0033] (1) Put 0.5g elemene and 10ml absolute ethanol in a conical flask, seal it, and ultrasonically disperse it for 5 minutes;

[0034] (2) Put 0.1g of mesoporous silica and 8ml of absolute ethanol in a Erlenmeyer flask and seal it, ultrasonically disperse for 15 minutes, and dissolve with magnetic stirring at 500 r / min at room temperature for 10 minutes. Slowly add the mixed solution of elemene and ethanol in step (1) to the solution in step b, and stir for 20-30 minutes at a speed of 500 r / min; after the dropwise addition is completed, continue stirring for 4 hours, centrifuged for 3 minutes, and the product was freeze-dried;

[0035] (3) Put 0.05g of mesoporous silica / elemene in step (2) and 7.5ml of deionized water into a conical flask, seal it, and ultrasonically disperse it for 5 minutes;

[0036] (4) Add the aqueous solution of mesoporous silica / elemene in step 3 to Tris buffer solution containing dopamine salt, stir magnetically at 500 r / min at room temperature for ...

Embodiment 3

[0038] (1) Put 1g of elemene and 10ml of absolute ethanol in a conical flask, seal it, and ultrasonically disperse it for 5 minutes;

[0039] (2) Put 0.1g of mesoporous silica and 5ml of absolute ethanol in a Erlenmeyer flask and seal it, ultrasonically disperse for 15 minutes, and dissolve with magnetic stirring at 500 r / min at room temperature for 10 minutes. Slowly add the mixed solution of elemene and ethanol in step (1) to the solution in step b, and stir for 20 to 30 minutes at a speed of 500 r / min; after the dropwise addition is completed, continue stirring for 4 hours, centrifuged for 3 minutes, and the product was lyophilized.

[0040] (3) Put 0.05g of mesoporous silica / elemene in step (2) and 5ml of deionized water into a conical flask, seal it, and ultrasonically disperse it for 5 minutes;

[0041] (4) Add the aqueous solution of mesoporous silica / elemene in step 3 to Tris buffer solution containing dopamine salt, stir magnetically at 500 r / min at room temperature ...

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Abstract

The invention discloses a preparation method and applications for a polydopamine coated mesoporous silica / elemene composite nanoparticle preparation. The preparation method includes dropwise adding anelemene and ethanol mixed solution into a mixed solution of mesoporous silica and deionized water under room temperature, performing centrifugation for 3 min after performing stirring for 4 h, and removing supernatant to obtain mesoporous silica / elemene composite nanoparticles; dropwise adding a mixed solution of the composite nanoparticles and the deionized water into a Tris buffer solution containing dopamine salt, performing stirring for 12 h at the room temperature, performing centrifugation for 3 min, and performing washing for 3 times with the deionized water; and obtaining polydopaminecoated mesoporous silica / elemene composite nanoparticles. The method can prepare polydopamine coated mesoporous silica / elemene nano-composite materials with different mass fractions. Through the showing of solid ultraviolet test results, good ultraviolet absorption can be achieved after polydopamine coats mesoporous silica / elemene nanoparticles, so that the nano preparation cannot be easily swallowed by a reticuloendothelial system and has good sustained release effects.

Description

technical field [0001] The invention belongs to the technical field of preparation and application of biomedical materials, and in particular relates to a preparation method and application of a polydopamine-wrapped mesoporous silica / elemene nanoparticle preparation. Background technique [0002] Elemene (Elemene, ELE) is a sesquiterpene compound extracted from turmeric (Ezhu) of Zingiberaceae. The main component is β-elemene with a molecular weight of 204.35. Its structure is as follows: [0003] [0004] Elemene can act on tumor cells through various pathways such as proteins, genes, and signal transduction pathways, induce tumor cell autophagy and apoptosis, inhibit tumor cell migration, reverse drug resistance, etc., and affect all stages of tumor occurrence and development . Unlike single-target drugs, the multi-target anticancer activity of elemene has become a new trend in the treatment of cancer. However, elemene is insoluble in water, easily volatilizes in vitr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/52A61K47/59A61K47/69A61K31/015A61P35/00
CPCA61K47/52A61K47/59A61K47/6935A61K31/015A61P35/00
Inventor 谢恬阎辉刘臻盛晓丹罗砚曦许梦娇王鑫
Owner HANGZHOU NORMAL UNIVERSITY
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