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Application of fructus hippophae water-soluble extract for preparing preparation capable of inhibiting phosphorylation of Tau protein

A water-soluble extract and phosphorylation technology, applied in the food field, can solve the problems of meaningless survival rate of patients, inability to guarantee the quality of life of patients, and inability to prevent the onset of Alzheimer's disease, and achieve the effect of increasing the extraction rate

Inactive Publication Date: 2020-05-15
JIAMUSI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Choline inhibitors can significantly inhibit the release of cholinesterase in the brain of patients with Alzheimer's disease, but they cannot prevent the onset of Alzheimer's disease
The use of choline inhibitors in the early stage of Alzheimer's disease can delay the progress of dementia and improve cognitive ability to a certain extent, but long-term use of choline inhibitors will cause symptoms such as nausea and vomiting, muscle paralysis, convulsions, and coma, which cannot guarantee the safety of patients. Quality of life, insignificant to improve patient survival
At present, clinical practice does not advocate the routine use of choline inhibitors to prevent and treat Alzheimer's disease or the prevention and treatment of early and late lesions

Method used

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  • Application of fructus hippophae water-soluble extract for preparing preparation capable of inhibiting phosphorylation of Tau protein
  • Application of fructus hippophae water-soluble extract for preparing preparation capable of inhibiting phosphorylation of Tau protein
  • Application of fructus hippophae water-soluble extract for preparing preparation capable of inhibiting phosphorylation of Tau protein

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] (1) Preparation of each water-soluble extract:

[0057] Sea buckthorn water-soluble extract:

[0058] ①Choose a large and plump seabuckthorn fruit and dry it in the shade at 15°C to obtain pretreated seabuckthorn;

[0059] ② Ultrasonic extraction was performed on the pretreated seabuckthorn, the ultrasonic time was 43min, the ultrasonic power was 600W, and the ultrasonic temperature was 55°C to obtain the ultrasonic extract of seabuckthorn;

[0060] ③Adjust the pH of the seabuckthorn ultrasonic extract to 3.0, then add pectinase and cellulase for enzymolysis reaction, the mass ratio of pectinase and cellulase is 1:1, the enzymolysis temperature is 32°C, and the stirring speed is 120r / min, the enzymolysis time is 30min, and seabuckthorn enzymolysis solution is obtained;

[0061] ④Continue to add hot water to the seabuckthorn enzymatic solution, the volume ratio of seabuckthorn enzymatic solution and hot water is 1:1, the temperature of the added hot water is 41°C, con...

Embodiment 2

[0084] (1) Preparation of each water-soluble extract:

[0085] Sea buckthorn water-soluble extract:

[0086] ①Choose a large and plump seabuckthorn fruit and dry it in the shade at 20°C to obtain pretreated seabuckthorn;

[0087] ② Ultrasonic extraction is performed on the pretreated seabuckthorn, the ultrasonic time is 30min, the ultrasonic power is 400W, and the ultrasonic temperature is 35°C to obtain the ultrasonic extract of seabuckthorn;

[0088] ③Adjust the pH of the seabuckthorn ultrasonic extract to 3.0, then add pectinase and cellulase for enzymolysis reaction, the mass ratio of pectinase and cellulase is 1.2:1, the enzymolysis temperature is 32°C, and the stirring speed is 65r / min, the enzymolysis time is 30min, and seabuckthorn enzymolysis solution is obtained;

[0089] ④Continue to add hot water to the seabuckthorn enzymatic solution, the volume ratio of seabuckthorn enzymatic solution and hot water is 1:1.3, the temperature of the added hot water is 42°C, cont...

Embodiment 3

[0111] (1) Preparation of each water-soluble extract:

[0112] Sea buckthorn water-soluble extract:

[0113] ①Choose a large and plump seabuckthorn fruit and dry it in the shade at 20°C to obtain pretreated seabuckthorn;

[0114] ② Ultrasonic extraction was performed on the pretreated seabuckthorn, the ultrasonic time was 35min, the ultrasonic power was 420W, and the ultrasonic temperature was 38°C to obtain the ultrasonic extract of seabuckthorn;

[0115] ③Adjust the pH of the seabuckthorn ultrasonic extract to 3.0, then add pectinase and cellulase for enzymolysis reaction, the mass ratio of pectinase and cellulase is 2:1, the enzymolysis temperature is 35°C, and the stirring speed is 70r / min, the enzymolysis time is 33min, and seabuckthorn enzymatic solution is obtained;

[0116] ④Continue to add hot water to the seabuckthorn enzymatic solution, the volume ratio of seabuckthorn enzymatic solution and hot water is 1:1.7, the temperature of the added hot water is 45°C, cont...

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Abstract

The invention discloses application of a fructus hippophae water-soluble extract for preparing a preparation capable of inhibiting the phosphorylation of a Tau protein. The fructus hippophae water-soluble extract accounts for 20-45 wt% of the preparation capable of inhibiting the phosphorylation of the Tau protein. Compared with the prior art, the invention has the following beneficial effects that (1) the phosphorylation of the Tau protein is inhibited so as to prevent and treat the Alzheimer's Disease, a choline inhibitor which is commonly used at present is not adopted, and therefore, no side effects are caused; and (2) through a synergistic effect of all substances, the Alzheimer's Disease is prevented and treated, each medicine independently performs an effect by aiming at the etiology and the pathogenesis of the Alzheimer's Disease and mutually coordinates, a prevention and treatment principle of strengthening the body resistance to eliminate pathogenic factors and addressing both symptoms and root causes is followed, all medicines are combined to jointly perform the efficacy of warming the kidney, strengthening the spleen, invigorating qi, consolidating superficies, and promoting blood circulation to remove meridian obstruction, the fructus hippophae water-soluble extract has an excellent prevention and treatment effect on the Alzheimer's Disease, and a cure rate is high.

Description

technical field [0001] The invention relates to the technical field of food, and more specifically relates to the application of a water-soluble extract of seabuckthorn in a preparation for inhibiting Tau protein phosphorylation. Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a neurodegenerative disease that mainly occurs in middle-aged and elderly people. Its pathogenesis is related to cholinergic damage, free radical damage, Aβ toxicity and neuroinflammation. It is a clinical disease with high morbidity and mortality among the elderly. Statistics show that the prevalence of Alzheimer's disease among the elderly is about 4.9%, and the average survival time of patients is only 5.5 years, ranking sixth among the causes of death in the world. With the gradual increase of people's life pressure and changes in lifestyle, bad living habits such as excessive use of the brain, irregular work and rest, and neurological diseases such as ins...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A23L29/00
CPCA23L29/06A23L33/105A23V2002/00A23V2250/21A23V2200/322
Inventor 赵宏孔令洲张宇高琪焦莹莹汤威威
Owner JIAMUSI UNIVERSITY
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