Radioactive microsphere and radioactive filler composition

A filling composition and radioactive technology, applied in microcapsules, tissue regeneration, drug delivery, etc., can solve the problems of tumor normal cell destruction, large radiation measurement, radiation attenuation, etc., and achieve the effect of inconvenient improvement

Pending Publication Date: 2020-05-29
PLATINUM OPTICS TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Traditional radiation therapy uses external radiation therapy to destroy or eliminate tumors, but the radiation is greatly attenuated after being shielded by the human body, resulting in the need to apply extremely large doses of radiation. However, these excessive doses will also cause damage to normal cells adjacent to the tumor

Method used

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  • Radioactive microsphere and radioactive filler composition
  • Radioactive microsphere and radioactive filler composition
  • Radioactive microsphere and radioactive filler composition

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preparation example Construction

[0050] The present invention also provides a method for preparing radiated microspheres, which comprises the chemical formula Ca 3 Si 2 o 7 A mixture of the indicated glass powder and yttrium oxide powder is fused to form glass; cooling the glass; grinding the glass to obtain glass powder; and flame spraying the glass powder to form radiated microspheres, wherein the sphericity of the radiated microspheres 0.71 to 1.

[0051] In a specific embodiment, the glass powder is collected in a cooling collection area after being sprayed with a flame to form radiation microspheres.

[0052] The cooling collection area can be a solid or liquid interface, the solid can be ice or dry ice, and the liquid can be a liquid (organic acid / inorganic acid) or water that can excite the components of the nuclei.

[0053] In a specific embodiment, the preparation method of the radiated microspheres further includes adding contrasting seed oxide powder into the mixture before melting the mixture. ...

Embodiment ( 1

[0059] will be given by the chemical formula Ca 3 Si 2 o 7 The indicated glass powder and yttrium oxide powder are uniformly ball-milled and mixed at a molar ratio of 80:20. After being melted to form glass, the powder is ground, and then the flame is sprayed on the high-speed gas (gas) mixed with acetylene and oxygen. Ratio 1.1 to 1.2) flame heating spray, flame temperature range 1200 ℃ to 2000 ℃, spray distance 50 cm, flight time 15 seconds, form radiation microspheres, these radiation microspheres are as figure 1 shown. These radiated microspheres were sampled for Waddle sphericity analysis (e.g. figure 2 and shown in Table 1), the sphericity of the obtained radiated microspheres was between 0.7276 and 1.

[0060] A sample of 10 mg of the radioactive microspheres was subjected to neutron activation irradiation. After neutron activation elemental analysis, Ca signals were observed, as shown in Table 2.

Embodiment ( 2

[0062] will be given by the chemical formula Ca 3 Si 2 o 7 The indicated glass powder and yttrium oxide powder are uniformly ball-milled and mixed at a molar ratio of 80:20, and then 5% by weight of ReO, 5% by weight of CuO, 5% by weight of TeO and other contrasting core oxide powders are added, and melted After the glass is formed, powder grinding is carried out, and then the flame is sprayed on the high-speed gas (gas ratio 1.1 to 1.2) mixed with acetylene and oxygen, and the flame is heated and sprayed. The flame temperature range is 1200 ° C to 2000 ° C, and the spray distance is 50 cm. The flight time is 15 seconds to form radioactive microspheres. Sampling 10 mg of these radioactive microspheres with ReO, CuO, and TeO respectively, was subjected to neutron activation irradiation. After neutron activation elemental analysis, signals of Re, Cu, and Te (I-131) were observed, as shown in Table 3. Show.

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Abstract

The invention provides a radioactive microsphere and radioactive filler composition. Provided is a radioactive microsphere including glass having a structure represented by a formula Ca3Si2O7 and yttrium oxide contained in the glass. The radioactive microsphere has sphericity of from 0.71 to 1, and is radioactive after being activated by neutron irradiation. The radioactive microspheres are delivered to target tissues for neutron activation to generate radiation to treatment tumors, the radioactivity of the microspheres disappears along with time, and finally, the microspheres can be dissolvedand absorbed through bone tissues.

Description

technical field [0001] The invention relates to a radioactive microsphere and a filling containing the radioactive microsphere, in particular to a radioactive filling composition for treating bone tumors. Background technique [0002] Skeletal tissue includes hard bone, cartilage, ligaments, and other connective tissues. It has functions such as support, leverage, responsible for human motor functions, protection of soft tissues in the body, storage, and production of blood cells. Therefore, when the bones of the human body are damaged due to internal diseases, external injuries, congenital abnormalities or aging, in addition to causing inconvenience in daily life, it may also cause damage to other organs. [0003] Among bone diseases, the more serious ones are tumors, including benign and malignant tumors. In the classification of tumors in the musculoskeletal system, only patients with benign grade 1 tumors do not need surgery, and the rest still use surgery as the main p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/50A61L27/58A61L27/02
CPCA61L27/02A61L27/50A61L27/54A61L27/58A61L2300/102A61L2300/416A61L2430/02A61K51/1251A61L27/10A61L27/34A61L27/42A61L27/44A61L2300/44A61L2300/604A61L2300/622C03B19/102C03C3/095C03C4/0014C03C4/0042C03C11/00C03C17/008C03C17/32A61K51/1255A61L27/025A61L27/12A61L27/16A61L27/18A61L27/20A61L2420/02C03C3/062C03C11/002C03C23/0045C03C2204/00
Inventor 蔡育佑张富毓刘建良
Owner PLATINUM OPTICS TECH
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