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Preparation method of traditional Chinese medicine anti-allergic agent tetrandrine

A technology of tetrandrine and tetrandrine, which is applied in the field of preparation of tetrandrine, which can solve the production environment and operator hazards, product residues, incomplete separation of tetrandrine and tetrandrine, etc. problems, to achieve the effect of improving raw material utilization, avoiding solvent residues, and reducing potential hazards

Inactive Publication Date: 2020-06-02
上海浙星新型材料科技有限公司
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the technology for extracting tetrandrine and tetrandrine [see "Handbook of Extraction and Separation of Chemical Components of Traditional Chinese Medicine" edited by Yang Yun and Feng Weiwei, P130-133; The monomeric alkaloids in the total alkaloids] have the following problems: the purification process uses benzene as a purification solvent to remove tetrandrin, which not only leaves residues in the finished product, but also poses potential hazards to the production environment and operators; it cannot be obtained at the same time Tetradin and Tetradin; Subsequent separation of Tetradin and Tetradine was not complete, which affected the quality of Tetradin products

Method used

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  • Preparation method of traditional Chinese medicine anti-allergic agent tetrandrine
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  • Preparation method of traditional Chinese medicine anti-allergic agent tetrandrine

Examples

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Embodiment 1

[0029] refer to Figure 1-2 , a preparation method of traditional Chinese medicine antisensitivity agent tetrandrine, comprising the following steps:

[0030] S1: Extraction of total alkaloids: Take 100g of Fangji powder, put it in a 500ml round-bottomed flask, add 300ml of ethanol, heat and reflux in a water bath for 1 hour, filter out the ethanol extract, add 200ml of ethanol to the dregs to extract once in the same method, and combine The two extracts are filtered, concentrated until they have no alcohol taste, and become syrupy to obtain the total alkaloids;

[0031] S2: Extract total alkaloids of tetrandrine: transfer the above-mentioned alkaloid extract into a beaker, add 1% hydrochloric acid to adjust the pH to 2, stir while heating, let stand, and filter to obtain a clear filtrate; add an equal volume of chloroform to the filtrate, and then add Adjust the pH of the ammonia water to be above 10, shake and extract in the separatory funnel, release the chloroform layer a...

Embodiment 2

[0042] refer to image 3 , a preparation method of tetrandrine, a traditional Chinese medicine antisensitivity agent. Compared with Example 1, the main difference of this example is that in this example, cyclohexane-ethyl acetate (1:3) is used to replace cyclohexane- Acetone (4:1) elution, in which ethyl acetate can be decomposed after remaining in the subsequent elution, in the subsequent replacement developer, cyclohexane: ethyl acetate: diethylamine (6:2:1) The effect of dissolving is better, and the residue is reduced. At the same time, acetone is a toxic substance, which affects the subsequent quality.

[0043]At the same time, when Tetrandrine and Tetrandrine are separated in Tetrandrine, the mixture of the two is dissolved in an appropriate amount of dilute acid water, and after alkalization, Tetrandrine is extracted with benzene, and Tetrandrine is extracted with chloroform. Instead of cold benzene, it is separated by the difference in solubility. It is safer and more...

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Abstract

The invention discloses a preparation method of a traditional Chinese medicine anti-allergic agent tetrandrine. The method comprises the following steps of: S1, extraction of total alksloid: putting 100g of stephania tetrandra powder into a 500ml round-bottom flask, adding 300ml of ethanol, conducting heating and refluxing in a water bath for 1h, filtering out an ethanol extracted solution, adding200ml of ethanol into decoction dregs again, performing extraction once again by the same method, combining the two extracted solutions, performing filtering, and conducting concentrating until no alcohol smell into a syrup. According to the invention, the solvent is added many times, main components in the stephania tetrandra powder are prepared in terms of total alkaloid, stephania tetrandra total alkaloid and mixed crystals. In the preparation process, through mutual superposition operation of filtration and extraction, the pH of materials in the corresponding steps is adjusted, after thetarget component is subjected to liquid-liquid extraction twice, tetrandrine and the fangchinoline are respectively obtained, then the two substances are separated through solubility difference, the raw material utilization rate is effectively increased, and the production cost is reduced.

Description

technical field [0001] The invention relates to the technical field of preparation of tetrandrine, in particular to a preparation method of a traditional Chinese medicine antisensitivity agent tetrandrine. Background technique [0002] Tetrandrine is a bisbenzylisoquinoline alkaloid extracted from the tuber root of the traditional Chinese medicine Fangji. It is a high-purity extract extracted from herbs. It has an analgesic effect, and can also increase the accumulation of chemotherapy drugs in tumor cells by inhibiting the overexpression of P-glycoprotein on the surface of tumor drug-resistant cells, and enhance the sensitivity of tumor cells to chemotherapy drugs. Clinically, it can be used For rheumatic pain, arthralgia, neuralgia, combined with low-dose radiation for lung cancer, patients in need can choose it with confidence under the guidance of a doctor. [0003] At present, the technology for extracting tetrandrine and tetrandrine [see "Handbook of Extraction and Se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/18
CPCC07D491/18
Inventor 梅海平
Owner 上海浙星新型材料科技有限公司
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