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Anthraquinone type medicine and nucleic acid compound nanometer delivery system and preparation method and application thereof

A delivery system and anthraquinone technology, applied in the field of anthraquinone drug and nucleic acid complex nano-delivery systems and their preparation, can solve problems such as uncontrollability, toxicity, low encapsulation efficiency, etc., to avoid leakage and achieve synergy effect of action

Active Publication Date: 2020-06-05
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, complex co-delivery vehicles may bring many potential problems, such as uncontrollability, toxicity and low loading efficiency, etc.

Method used

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  • Anthraquinone type medicine and nucleic acid compound nanometer delivery system and preparation method and application thereof
  • Anthraquinone type medicine and nucleic acid compound nanometer delivery system and preparation method and application thereof
  • Anthraquinone type medicine and nucleic acid compound nanometer delivery system and preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0040] Example 1. Preparation method and application of doxorubicin and siRNA (P-h-D / siRNA) complex nanoparticles modified by polyethylene glycol hydrazone bond

[0041] 1. Preparation of PEG-hyd-DOX

[0042] First, methoxypolyethylene glycol (mPEG2000, 2g, 1mmol) and triethylamine (Triethylamine, TEA, 0.252g, 2.5mmol) were dissolved in anhydrous tetrahydrofuran, and anhydrous tetrahydrofuran was added into the constant pressure dropping funnel. p-Nitrophenyl chloroformate (4-Nitrophenyl chloroformate, NPC, 0.5 g, 2.5 mmol) was added dropwise in an ice bath, and reacted for 12 hours. After removing the generated triethylamine salt with a sand core funnel, it was precipitated three times in cold ether, and dried in vacuum to obtain NPC-modified polyethylene glycol (mPEG-NPC).

[0043] mPEG-NPC (1 g, 0.462 mmol) was dissolved in 15 mL of dichloromethane. After dissolving at 40° C., hydrazine hydrate (245 mg, 4.9 mmol) was added dropwise and reacted for 24 h. The product was pr...

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Abstract

The invention discloses an anthraquinone type medicine and nucleic acid compound nanometer delivery system and a preparation method and application thereof. The anthraquinone type medicine and nucleicacid compound nanometer delivery system comprises nucleic acids and hydrophilic polymer modified anthraquinone type medicines, wherein the anthraquinone type medicines contain one or more groups of primary amines, secondary amines and tertiary amines. Assembled nanometer particles can improve the in vivo stability of the nucleic acids, and through combination with micromolecule medicines, synergistic reactions are realized.

Description

technical field [0001] The invention relates to the field of nano-drug carriers, in particular to a nano-delivery system of anthraquinone drugs and nucleic acid complexes, a preparation method and application thereof. Background technique [0002] Nucleic acid drugs refer to DNA or RNA that has the function of treating diseases. Compared with traditional small molecule drugs and antibody drugs, nucleic acid drugs can regulate the expression of disease-causing genes from the root, and can achieve sequence specificity at the single base level. It has the characteristics of treating symptoms and root causes. In addition, nucleic acid drugs have the advantages of high therapeutic efficiency, low drug toxicity, strong specificity, and wide application fields. [0003] Because nucleic acid drugs are very unstable, they are easily degraded by nucleases in plasma when administered in vivo, and are also easily eliminated by filtration through the glomerular basement membrane with a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/713A61K31/704A61K47/55A61K47/60A61K9/14A61P35/00
CPCA61K45/06A61K31/713A61K31/704A61K47/55A61K47/60A61K9/146A61P35/00A61K2300/00
Inventor 杨显珠许维嘉陈森飚李冬冬都小姣王均
Owner SOUTH CHINA UNIV OF TECH