Preparation method and application of silicate long afterglow probe

A long afterglow, silicate technology, applied in chemical instruments and methods, medical preparations containing active ingredients, pharmaceutical formulations, etc. The effect of short synthesis cycle and simple reaction route

Active Publication Date: 2020-06-16
XIAMEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-lasting luminescent materials also have certain limitations, that is, the excitation light source is usually a high-energy ultraviolet irradiation material to achieve afterglow luminescence. The biggest limitation of ultraviolet light in biomedical imaging is that the penetration depth of the light sou

Method used

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  • Preparation method and application of silicate long afterglow probe
  • Preparation method and application of silicate long afterglow probe
  • Preparation method and application of silicate long afterglow probe

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Embodiment 1

[0055] (1) Zinc nitrate, gallium nitrate, germanium nitrate, ytterbium nitrate, chromium nitrate and erbium nitrate are mixed and added into water and stirred and dissolved to obtain a mixed metal solution; the concentration ratio of zinc, gallium, germanium, ytterbium, chromium and erbium in the mixed metal solution 1.5M: 1M: 0.5M: 0.25M: 0.05M: 0.25M;

[0056] (2) Evenly add 2 mL of the above mixed metal solution dropwise to 100 mg of mesoporous silica powder;

[0057] (3) The material obtained in step (2) was sequentially roasted at 110°C for 2h and 850°C for 5h to obtain the pre-product mZGGOs (mSiO 2 @Zn 3 Ga 2 GeO 8 : 1%Cr 3+ , 5%Yb 3+ , 0.5% Er 3+ );

[0058] (4) 20 mg of the above-mentioned pre-product mZGGOs was stirred and reacted in a sodium hydroxide solution of pH=10 for 9-15 hours, and then centrifuged, fully washed (three times) and dried to obtain the above-mentioned hydroxylated pre-product;

[0059] (5) Disperse the above-mentioned hydroxylated pre-pr...

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Abstract

The invention discloses a preparation method and an application of a silicate long afterglow probe. Mesoporous silicon dioxide is used as a template, zinc nitrate, gallium nitrate, germanium nitrate,ytterbium nitrate, chromic nitrate and erbium nitrate are used as doped metal raw materials, the doped metal raw materials are dissolved in water and uniformly mixed, the mixture is dropwise added into the mesoporous silicon dioxide, roasting is performed at high temperature, and a pre-product is obtained after roasting is finished; then, functional modification is performed on the surface of thepre-product, and hydroxylation, amination and PEG modification are sequentially performed to obtain a modified pre-product; and finally, a photosensitizer silicon dichloride phthalocyanine is loaded to obtain the silicate long afterglow probe. The silicate long-afterglow probe has good biological safety, after caudal vein injection and under X-ray irradiation, a tumor area is effectively enriched,deep in-situ tumor imaging is achieved, in-situ tumor cells are seriously killed, and finally diagnosis and treatment integration of the silicate long-afterglow probe on deep tumors is achieved.

Description

technical field [0001] The invention belongs to the technical field of in situ treatment and diagnosis of liver cancer, and in particular relates to a preparation method and application of a silicate long afterglow probe. Background technique [0002] Cancer, as one of the main threats to human life and health, has been increasing in incidence and mortality in recent decades, and has become a major disease that takes human life. Among them, liver cancer is called "the king of cancer" in my country, and liver cancer is also known as the fifth most common cancer in men and the ninth most common cancer in women in the world; more than half of the new cases in the world every year occur in my country. Liver cancer has become a major disease that affects the life and health of our people and a major health burden for society. Therefore, the effective prevention, diagnosis and treatment of liver cancer are the top priority of biomedical research. At present, the main effective me...

Claims

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Application Information

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IPC IPC(8): C09K11/66C09K11/06B82Y30/00B82Y40/00A61K41/00A61P35/00
CPCA61K41/0057A61P35/00B82Y30/00B82Y40/00C09K11/06C09K11/7775C09K11/7776C09K2211/1085
Inventor 陈洪敏史天航孙文静陈小元
Owner XIAMEN UNIV
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