Preparation method of sleeping dispersible tablets

A technology of dispersible tablets and extractors, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of inability to remove hydrophilic ingredients, affect the next tableting process Particles are easy to absorb moisture and other problems, to achieve the effect of shortening the disintegration time limit, improving bioavailability, and high bioavailability

Inactive Publication Date: 2020-06-19

WUXI JIMIN KEXIN SHANHE PHARMA

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AI-Extracted Technical Summary

Problems solved by technology

This method cannot remove mucus, gums, pectin, tannins, polysaccharides, proteins and other hydrophilic components in the water extract, resulting ...

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Abstract

The invention provides a preparation method of sleeping dispersible tablets. The preparation method of sleeping dispersible tablets is characterized by comprising the steps: adopting semen ziziphi spinosae, radix bupleuri, radix paeoniae alba, albizia flowers, cortex albiziae and bombyx batryticatus as raw medicinal materials, performing water extraction and alcohol precipitation so as to obtain effective ingredients, performing fine crushing on a raw medicinal material periostracum cicada so as to obtain fine powder, performing reflux extraction on a raw medicinal material medulla junci by using ethanol so as to obtain effective ingredients, performing vacuum concentration on all the effective ingredients so as to obtain clear paste with a relative density of 1.05-1.10, performing spray drying, mixing the dried paste with the periostracum cicada fine powder, adding auxiliary materials, performing dry granulation, and performing compression into tablets so as to obtain the sleeping dispersible tablets. The sleeping dispersible tablets which is prepared by using the method has a short time of disintegration, fast effects, simple steps, industrial production and a high value of clinical application.

Application Domain

Nervous disorderAnthropod material medical ingredients +3

Technology Topic

ChemistryMedicinal herbs +8

Image

Examples

Experimental program(3)

Example Embodiment

[0040] Example 1

[0041] A preparation method of Shumian dispersible tablet, comprising the following steps:

[0042] (1) Take 600g of jujube seed, 350g of Bupleurum, 350g of Radix Paeoniae Alba, 450g of Albizia Julibrissin, 450g of Albizia Julibrissin, 250g of Silkworm, add 10 times the amount of water, heat and boil the medicinal materials, keep boiling for 1 hour, decocted Cook twice, combine the decoction liquid, let the liquid cool down to room temperature and then add ethanol to make the alcohol content 75%, stir while adding, transfer to the cold storage after the addition, and let stand at 5-10 ° C for 24 hours, filter the supernatant with suction.

[0043] (2) Take 25 g of the medicinal material rushes and place it in an extractor, add 8 times the amount of ethanol, extract twice by reflux, and combine the extracts.

[0044](3) The above-mentioned supernatant and extract were combined, concentrated under reduced pressure to a clear paste with a relative density of 1.05 (70° C.), and spray-dried into fine powder.

[0045] (4) Crushing 250 g of the medicinal material cicada slough into fine powder, passing through an 80-mesh sieve.

[0046] (5) Mix the above-mentioned spray-dried fine powder and cicada slough fine powder evenly, add the mixture of auxiliary material disintegrant 10 g of hydroxypropyl cellulose and 20 g of sodium carboxymethyl starch, 20 g of filler microcrystalline cellulose and 10 g of starch, and prepare by dry method. particles.

[0047] (6) Add 1 g of lubricant calcium hydrogen phosphate and 1 g of magnesium stearate to the above granules, mix well, and press into 0.4 g/tablet with a tablet machine to obtain Shumian dispersible tablets.

Example Embodiment

[0048] Example 2

[0049] A preparation method of Shumian dispersible tablet, comprising the following steps:

[0050] (1) Take 650g of Suanzao Ren, 380g of Bupleurum, 380g of Paeonia lactiflora, 480g of Albizia Julibrissin, 480g of Albizia Julibrissin, and 300g of Silkworm, add 10 times the amount of water, heat and boil the medicinal materials, keep boiling for 1 hour, decocted Cook twice, combine the decoction liquid, let the liquid cool down to room temperature and then add ethanol to make the alcohol content 75%, stir while adding, transfer to the cold storage after the addition, and let stand at 5-10 ° C for 24 hours, filter the supernatant with suction.

[0051] (2) Take 30 g of the medicinal material rushes and place it in an extractor, add 8 times the amount of ethanol, extract twice by reflux, and combine the extracts.

[0052] (3) The above-mentioned supernatant and extract were combined, concentrated under reduced pressure to a clear paste with a relative density of 1.07 (70° C.), and spray-dried into fine powder.

[0053] (4) Crush 300 g of the medicinal material Cicada slough into fine powder, and pass through an 80-mesh sieve.

[0054] (5) Mix the above-mentioned spray-dried fine powder and cicada slough fine powder evenly, add the mixture of auxiliary material disintegrant 10 g of hydroxypropyl cellulose and 20 g of sodium carboxymethyl starch, 20 g of filler microcrystalline cellulose and 10 g of starch, and prepare by dry method. particles.

[0055] (6) Add 1 g of lubricant calcium hydrogen phosphate and 1 g of magnesium stearate to the above granules, mix well, and press into 0.45g/tablet with a tablet machine to obtain Shumian dispersible tablets.

Example Embodiment

[0056] Example 3

[0057] A preparation method of Shumian dispersible tablet, comprising the following steps:

[0058] (1) Take 700g of jujube seed, 400g of Bupleurum, 400g of Radix Paeoniae Alba, 500g of Albizia Julibrissin, 500g of Albizia Julibrissin, 350g of Silkworm, add 10 times the amount of water, heat and boil the medicinal materials, keep boiling for 1 hour, decocted Cook twice, combine the decoction liquid, let the liquid cool down to room temperature and then add ethanol to make the alcohol content 75%, stir while adding, transfer to the cold storage after the addition, and let stand at 5-10 ° C for 24 hours, filter the supernatant with suction.

[0059] (2) Take 35 g of the medicinal material rushes and place it in an extractor, add 8 times the amount of ethanol, extract twice by reflux, and combine the extracts.

[0060] (3) The above-mentioned supernatant and extract were combined, concentrated under reduced pressure to a clear paste with a relative density of 1.10 (70° C.), and spray-dried into fine powder.

[0061] (4) Crushing 350 g of the medicinal material cicada slough into fine powder, passing through an 80-mesh sieve.

[0062] (5) Mix the above-mentioned spray-dried fine powder and cicada slough fine powder evenly, add the mixture of auxiliary material disintegrant 10 g of hydroxypropyl cellulose and 20 g of sodium carboxymethyl starch, 20 g of filler microcrystalline cellulose and 10 g of starch, and prepare by dry method. particles.

[0063] (6) Add 1 g of lubricant calcium hydrogen phosphate and 1 g of magnesium stearate to the above granules, mix well, and press into 0.5 g/tablet with a tablet machine to obtain Shumian dispersible tablets.

[0064] Quality comparison results

[0065] 1. Content comparison

[0066] The content of paeoniflorin in the Shumian dispersible tablets prepared in the three examples is compared with the content of paeoniflorin in the national drug standard of Shumian tablets as shown below.

[0067]

[0068]

[0069] 2. Comparison of disintegration time limit

[0070] In the three examples, the disintegration time of the prepared Shumian dispersible tablet is no more than 3 minutes, while the disintegration time of the ordinary Shumian tablet is 47 minutes. Therefore, the Shumian dispersible tablet of the invention has a faster onset and is more conducive to absorption. .

[0071]

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Description & Claims & Application Information

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Classification and recommendation of technical efficacy words

Good dispersion
Fast disintegration

Preparation method of sleeping dispersible tablets

AI-Extracted Technical Summary

Problems solved by technology

Abstract

Image

Examples

Example Embodiment

Example Embodiment

Example Embodiment

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Description & Claims & Application Information

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