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Preparation method of sleeping dispersible tablets

A technology of dispersible tablets and extractors, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of inability to remove hydrophilic ingredients, affect the next tableting process Particles are easy to absorb moisture and other problems, to achieve the effect of shortening the disintegration time limit, improving bioavailability, and high bioavailability

Inactive Publication Date: 2020-06-19
WUXI JIMIN KEXIN SHANHE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method cannot remove mucus, gums, pectin, tannins, polysaccharides, proteins and other hydrophilic components in the water extract, resulting in the fact that in actual production, the obtained granules are very easy to absorb moisture, which affects the next tableting process. more loss

Method used

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  • Preparation method of sleeping dispersible tablets
  • Preparation method of sleeping dispersible tablets
  • Preparation method of sleeping dispersible tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A preparation method of Shumian Dispersible Tablets, comprising the following steps:

[0042] (1) Take 600g jujube seed, 350g Bupleuri, 350g white peony, 450g Albizia julibrissin, 450g Albizia juniper skin, and 250g silkworm, and put them in the extractor, add 10 times the amount of water, heat and boil the medicinal materials, keep boiling for 1 hour, and fry Boil twice, combine the decoction liquid, and add ethanol after the liquid is allowed to cool to room temperature, so that the alcohol content is 75%, stir while adding, move to the cold storage after the addition is completed, and stand at 5-10°C for 24 hours, filter the supernatant with suction.

[0043] (2) Take 25 g of the medicinal material rushes and place it in an extractor, add 8 times the amount of ethanol, reflux extraction twice, and combine the extracts.

[0044](3) The above supernatant and extract were combined, concentrated under reduced pressure to a clear paste with a relative density of 1.05 (70...

Embodiment 2

[0049] A preparation method of Shumian Dispersible Tablets, comprising the following steps:

[0050] (1) Take 650g jujube seed, 380g bupleurum, 380g white peony root, 480g albizia julibrissin, 480g albizia juniper skin, and 300g silkworm, and put them in an extractor, add 10 times the amount of water, heat and boil the medicinal materials, keep boiling for 1 hour, and fry Boil twice, combine the decoction liquid, and add ethanol after the liquid is allowed to cool to room temperature, so that the alcohol content is 75%, stir while adding, move to the cold storage after the addition is completed, and stand at 5-10°C for 24 hours, filter the supernatant with suction.

[0051] (2) Take 30 g of rushes, a medicinal material, and place it in an extractor, add 8 times the amount of ethanol, perform reflux extraction twice, and combine the extracts.

[0052] (3) The above supernatant and extract were combined, concentrated under reduced pressure to a clear paste with a relative densi...

Embodiment 3

[0057] A preparation method of Shumian Dispersible Tablets, comprising the following steps:

[0058] (1) Take 700g jujube seed, 400g bupleurum, 400g white peony root, 500g albizia julibrissin, 500g albizia juniper skin, and 350g silkworm, and put them in the extractor, add 10 times the amount of water, heat and boil the medicinal materials, keep boiling for 1 hour, and fry Boil twice, combine the decoction liquid, and add ethanol after the liquid is allowed to cool to room temperature, so that the alcohol content is 75%, stir while adding, move to the cold storage after the addition is completed, and stand at 5-10°C for 24 hours, filter the supernatant with suction.

[0059] (2) Take 35 g of the medicinal material rushes and place it in an extractor, add 8 times the amount of ethanol, reflux extraction twice, and combine the extracts.

[0060] (3) The above supernatant and extract were combined, concentrated under reduced pressure to a clear paste with a relative density of 1...

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Abstract

The invention provides a preparation method of sleeping dispersible tablets. The preparation method of sleeping dispersible tablets is characterized by comprising the steps: adopting semen ziziphi spinosae, radix bupleuri, radix paeoniae alba, albizia flowers, cortex albiziae and bombyx batryticatus as raw medicinal materials, performing water extraction and alcohol precipitation so as to obtain effective ingredients, performing fine crushing on a raw medicinal material periostracum cicada so as to obtain fine powder, performing reflux extraction on a raw medicinal material medulla junci by using ethanol so as to obtain effective ingredients, performing vacuum concentration on all the effective ingredients so as to obtain clear paste with a relative density of 1.05-1.10, performing spray drying, mixing the dried paste with the periostracum cicada fine powder, adding auxiliary materials, performing dry granulation, and performing compression into tablets so as to obtain the sleeping dispersible tablets. The sleeping dispersible tablets which is prepared by using the method has a short time of disintegration, fast effects, simple steps, industrial production and a high value of clinical application.

Description

technical field [0001] The present invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of a dispersible tablet of Shumian Anshen drug Background technique [0002] The prescription of Shumian Tablets comes from the National Drug Standard YBZ12072005-2009Z of the State Food and Drug Administration. The composition of the formula is as follows: 650g jujube seed, 380g Bupleurum, 380g white peony, 480g Albizia julibrissin, 480g albizia juniper bark, 300g silkworm, 300g cicada slough, and 30g rush. Functions and indications: Soothing the liver and relieving depression, nourishing blood and softening the liver, calming the mind and calming the nerves, used for insomnia, dreaminess and fright; sentimental or melancholy, or even irritable and irritable; fullness of chest and hypochondrium or poor chest and diaphragm; dizziness and dizziness ; Dry throat and dry mouth. With the acceleration of the pace of mo...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61K9/20A61K47/36A61K47/38A61P25/20A61K35/64
CPCA61K9/2054A61K9/2059A61K35/64A61K36/233A61K36/48A61K36/65A61K36/71A61K36/725A61K36/88A61K2236/33A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P25/20A61K2300/00
Inventor 王丹丹朱音於江华刘薇薇俞婷
Owner WUXI JIMIN KEXIN SHANHE PHARMA
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