Quality control method of golden cicada oral liquid
A quality control method, the technology of Jinchan Oral Liquid, is applied in the quality control of Jinchan Oral Liquid and the quality control of preparations in medical institutions. The quality of cicada oral liquid and other problems have been solved, and the quality control system has been perfected, the separation effect is excellent, and the reproducibility is good.
Active Publication Date: 2020-06-19
SOOCHOW UNIV AFFILIATED CHILDRENS HOSPITAL
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Problems solved by technology
However, its quality control methods are still not perfect so far, which is not conducive to the further development of Jinchan oral liquid preparations.
[0003] The existing Jinchan Oral Liquid quality control method generally chooses baicalin as the quality control method of Jinchan Oral Liquid, but the content determination of a single component cannot comprehensively determine the quality of Jinchan Oral Liquid.
Method used
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Embodiment 1
[0035] 1.1 Determination of Jin Chan Oral Liquid:
[0036] Chromatographic column: BEH C18 chromatographic column (2.1×50mm, 1.7um); mobile phase: A-acetonitrile; B-0.1% phosphoric acid aqueous solution as the mobile phase, gradient elution is performed according to Table 1, and the flow rate is 0.3mL·min -1 , The detection wavelength is 230nm, and the column temperature is 35°C.
[0037] Table 1 Gradient elution program
[0038]
[0039] Preparation of the sample solution to be tested: Precisely measure 1mL of Jinchan oral liquid, place it in a 25mL volumetric flask, dilute with water to the 25ml mark of the volumetric flask, and centrifuge for use.
[0040] Preparation of reference solution: accurately weigh appropriate amounts of chlorogenic acid, luteolin, and baicalin reference substances, and dissolve them in methanol to prepare 0.05 mg, 0.05 mg, and 0.05 mg containing chlorogenic acid, luteolin and baicalin, respectively The solution is used as a qualitative reference solution....
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Abstract
The invention discloses a quality control method of golden cicada oral liquid. The method comprises the following steps: respectively detecting a to-be-detected sample solution and a reference substance solution by adopting ultra-high performance liquid chromatography, wherein the reference substance solution must comprise a first reference substance solution containing chlorogenic acid, a secondreference substance solution containing luteoloside and a third reference substance solution containing baicalin; wherein a chromatographic column adopted by the ultra-high performance liquid chromatography takes octadecyl bonded silica gel as a filler, an adopted mobile phase is a mixture of methanol and acid water or a mixture of acetonitrile and acid water, and the solute volume percentage content of the acid water is 0.02-0.2%; the control method can comprehensively reflect the quality of the golden cicada oral liquid, and is simple to operate and easy for industrial application.
Description
Technical field [0001] The invention belongs to the technical field of quality control, in particular to a quality control of preparations for medical institutions, and in particular to a quality control method of Jinchan oral liquid. Background technique [0002] Jin Chan Oral Liquid is a medical institution preparation of the Children's Hospital of Soochow University. It is developed based on the clinical experience of Wu Baode, a well-known and veteran Chinese doctor, and has been used in clinical practice for more than 20 years. The main function of the preparation is to sooth the surface, relieve the muscles and clear away the heat. It is clinically mainly used for wind-heat and cold, fever, aversion to cold, sore throat, etc., with good curative effect. In the preliminary research process, it was found that the preparation is useful in the treatment of pediatric hand, foot and mouth disease, acute upper respiratory tract infection, syncytial virus pneumonia, mild to moderat...
Claims
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IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/86
CPCG01N30/02G01N30/06G01N30/34G01N30/8686G01N2030/047
Inventor 金慧臻吕海涛毛晨梅孟永钦朱增燕
Owner SOOCHOW UNIV AFFILIATED CHILDRENS HOSPITAL