Biofilm for guiding oral bone regeneration and preparation method thereof

Abstract

The present invention relates to a guided bone regeneration (GBR) biofilm, which is characterized in that the layer (layer A) in contact with the oral cavity periodontal soft tissue is a decellularized breeding stock ECM film with good cross-linking To prevent premature degradation of the A layer membrane, so that the isolation effect is more durable; at the same time, the layer (B layer) in contact with the alveolar bone defect is the decellularized ECM membrane of young animals, such as the periosteum of the piglet's leg or the mucosa of the small intestine The lower layer; the B layer derived from young animals contains more bioactive factors (such as HA) and has a strong ability to induce tissue regeneration; this type of GBR membrane has both long-lasting isolation effects and good bone tissue regeneration functions, and is completely degradable and degradable. Absorption; no cross-linking agent is used in production to enhance the anti-enzymolysis performance and avoid cross-linking agent residue; the GBR membrane of the present invention is not only conducive to guiding the high-quality reconstruction of bone tissue, but also inducing its early regeneration, which can take into account both Good and fast.

Description

technical field [0001] The invention belongs to the field of absorbable biomaterials for oral cavity, and in particular relates to a biofilm guiding oral cavity bone regeneration and a preparation method thereof. Background technique [0002] At present, with the continuous improvement of living standards, dental implant restoration has become the first choice for patients with missing teeth. However, the key to the success of dental implant restoration is sufficient alveolar bone stock or sufficient alveolar bone augmentation in the missing tooth. However, Clinically, due to various factors such as age, constitution, inflammation, trauma, disuse atrophy, jaw tumor surgery, congenital tooth loss, etc., there are a large number of cases where conventional implant restoration cannot be performed due to insufficient height or width of available bone in the implant area. . [0003] In the early 1980s, the scientific concept of guided tissue regeneration (Guided Tissue Regenerat...

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Problems solved by technology

[0018] In view of the deficiencies and deficiencies of the existing guided bone regeneration composite membrane, the first purpose of the present invention is to provide a composite film that does not use any chemical cross-linking agent or use physical cross-linking methods, but has good resistance to enzymatic degradation. , a more stable natural GBR collagen film that can act as a long-lasting isolation barrier; this type of natural biofilm must have good biocompatibility, be degradable and absorbable, and have no chemical reagent residue. More importantly, it must be able to overcome The existing natural GBR collagen membrane has poor stability, rapid degradation, and short-lasting barrier effect; it can prevent the gingival soft tissue from entering the bone growth area for a longer period of time, and reserve sufficient space for new bone growth in the bone defect area. Regenerate space, and guide osteoblasts to grow into new bone in the bone defect area, so as to achieve the purpose of bone healing

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