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Phenylethylamine production method and equipment

A technology for production equipment and production methods, applied in the field of production methods, can solve problems such as protein residues and difficult recycling, achieve the effects of mild conditions, reduce the generation of waste acid, and shorten the production cycle

Pending Publication Date: 2020-06-30
ENZYMASTER NINGBO BIO ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, in actual production, the use of transaminase has the following disadvantages: it is difficult to recycle in the reaction; there is a problem of protein residue in the reaction solution

Method used

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  • Phenylethylamine production method and equipment
  • Phenylethylamine production method and equipment
  • Phenylethylamine production method and equipment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] This embodiment is a schematic embodiment of the production method and production equipment of phenethylamine of the present invention.

[0103] In the present invention, phenethylamine is R-(+)-1-phenylethylamine, and the sequence of transaminase is shown in the table below:

[0104] Table 1 Transaminase sequence list

[0105]

[0106]

[0107] Such as figure 1 Shown, a kind of phenylethylamine production equipment comprises the first reaction unit 1, the second reaction unit 2, the third reaction unit 3, circulation unit 4, acetone storage unit 5, centrifugal extraction unit 6, phenethylamine treatment unit and The phenylethylamine storage device 10, the first reaction device 1, the third reaction device 3, the second reaction device 2 and the circulation device 4 are connected by pipelines to form a flow circulation loop, and the circulation device 4 is connected with the acetone storage device 5 and the centrifugal extraction device respectively. 6 are conne...

Embodiment 2

[0196] This embodiment is an embodiment of the circulation loop of the present invention.

[0197] Such as image 3 As shown, the circulation loop comprises a first reaction device 1, a second reaction device 2, several third reaction devices 3 and a circulation device 4, wherein the outlet pipe of the circulation device 4 is connected with the liquid inlet pipe, The liquid inlet pipeline of the second reaction device 2 is connected with the liquid inlet pipeline of some third reaction devices 3, and the liquid inlet pipeline of the circulation device 4 is connected with the liquid outlet pipeline of the first reaction device 1 and the liquid outlet of the second reaction device 2 respectively. The pipelines are connected, the liquid outlet pipeline of the first reaction device 1 is connected with the liquid inlet pipeline of the second reaction device 2 and the liquid inlet pipeline of some third reaction devices 3 respectively, and the liquid outlet pipeline of the second re...

Embodiment 3

[0203] This embodiment is a specific embodiment of the present invention. Apply the production equipment of phenethylamine of the present invention, in the production system, take 1000L as a benchmark, place transaminase wet thallus in the middle chamber of the first reaction device 1, the second reaction device 2 and the third reaction device 3 75Kg, then add 800L of acetophenone, 120Kg of isopropylamine, and 100g of pyridoxal phosphate into the circulation device 4 to start the cycle reaction after stirring, the temperature range is 35-45°C, the circulation flow rate is 500-700kg / h, and the pressure range is 0.15-0.2 Mpa, the reaction time is 20-26h, and the product can be accumulated to 170Kg / L, and the post-treatment and unreacted acetophenone and isopropanol can be separated by the reaction device and method in Example 1. Recovered acetophenone and isopropanol can also be put back into production. The transaminase wet cells in the middle chamber can be reused, and the ac...

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Abstract

The present invention relates to phenylethylamine production equipment. The phenylethylamine production equipment comprises a first reaction device, a second reaction device connected with the first reaction device, a circulating device connected with the first reaction device and the second reaction device, an acetone storage device, a centrifugal extraction device, a phenylethylamine treatment device and a phenylethylamine storage device, wherein the first reaction device and the second reaction device have the same structure. The invention also relates to a phenylethylamine production method. The method has the advantages that transaminase is used as a catalyst, so that acetophenone and isopropyl amine can react through the transaminase, a reaction is completed in one step, the production period is shortened, and the production cost is reduced; through the flow type circular reaction, the transaminase can be recycled, so that the production cost is further reduced; and the enzyme-catalyzed reaction taking water as a solvent is mild in condition, thereby avoiding dangerous operation of high-temperature high-pressure and catalytic hydrogenation and the like in an existing chemicalprocess.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical intermediates, and in particular relates to a production method of phenethylamine, and also relates to a production equipment of phenethylamine. Background technique [0002] R-(+)-1-phenylethylamine is an important pharmaceutical intermediate, and there is a global market demand of several thousand tons every year. The existing process uses acetophenone as the starting material, and hydrogenates it with liquid ammonia at high temperature and high pressure under the catalysis of nickel metal to prepare racemic phenylethylamine. The reaction conditions are quite severe, flammable and explosive, and it is harmful to equipment and operators. Make high demands. Racemic phenethylamine adopts equivalent resolving agent to resolve to obtain R configuration phenethylamine, the resolution efficiency is low, and the yield is only 30%, and the e.e. value of the product is limited by technology and ca...

Claims

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Application Information

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IPC IPC(8): C12P13/00C12M1/40C12M1/00
CPCC12P13/001C12M21/18C12M29/18C12M23/58C12M47/10C12M33/10
Inventor 杨朱红王子坤黄勇开王吉勇蔡宝琴朱莹刘建民马治鹏张宝华竺淮豪马克·博科拉吕瑜明孙保国吕震林
Owner ENZYMASTER NINGBO BIO ENG CO LTD
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