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Core-shell hollow Cu(OH)2@Au@Co(OH)2 composite material as well as preparation method and application thereof

A composite material and core-shell technology, applied in analytical materials, chemical instruments and methods, material analysis through electromagnetic means, etc., can solve the problems of cumbersome enzyme protein synthesis process, general enzyme sensing stability, and reduced accuracy. Accelerated electron transfer rate, short charge-sensing path, and improved performance

Active Publication Date: 2020-07-03
WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limitation that the enzyme is a protein, it is easily inactivated by environmental influences such as temperature, humidity, pH and other toxic substances, reducing the accuracy
In addition, the enzyme protein synthesis process is cumbersome, high cost, and has the disadvantages of easy peeling from the electrode surface.
Therefore, enzyme sensing stability is generally

Method used

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  • Core-shell hollow Cu(OH)2@Au@Co(OH)2 composite material as well as preparation method and application thereof
  • Core-shell hollow Cu(OH)2@Au@Co(OH)2 composite material as well as preparation method and application thereof
  • Core-shell hollow Cu(OH)2@Au@Co(OH)2 composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] (1) Prepare 20mM K 3 Fe(CN) 6 and 20mM CoCl 2 The aqueous solution was simultaneously injected into the reaction vessel at a rate of 600 μL / min to generate Co 2 [Fe(CN) 6 ] 3 ; Prepare 1mM HAuCl 4 aqueous solution and injected Co at a rate of 300 μL / min 2 [Fe(CN) 6 ] 3 solution, stirred for 30min; then prepared 7mM C 6 h 8 o 6 aqueous solution and added reduced HAuCl at a rate of 500 μL / min 4 , generating Au@Co 2 [Fe(CN) 6 ] 3 , centrifuge the solution at a centrifugal rate of 3000r / min for 10min and redisperse it in 30mL volume water;

[0045] (2) Prepare 20mM K 3 Fe(CN) 6 and 20mM CuCl 2 Aqueous solution was simultaneously injected into Au@Co at a rate of 300 μL / min 2 [Fe(CN) 6 ] 3 In the aqueous solution, centrifuge the solution at a centrifugal rate of 3000r / min for 10min and redisperse in 30mL ethanol solution;

[0046] (3) Prepare 0.4M NaOH aqueous solution and add 20mL to the above ethanol solution, and obtain Cu(OH) after ultrasonication for...

Embodiment 2

[0050] (1) Prepare 5mM K 3 Fe(CN) 6 and 5mM CoCl 2 The aqueous solution was simultaneously injected into the reaction vessel at a rate of 500 μL / min to generate Co 2 [Fe(CN) 6 ] 3 ; Prepare 5mM HAuCl 4 aqueous solution and injected Co at a rate of 200 μL / min 2 [Fe(CN) 6 ] 3 solution, stirred for 30min; then prepared 35mM C 6 h 8 o 6 aqueous solution and added reduced HAuCl at a rate of 400 μL / min 4 , generating Au@Co 2 [Fe(CN) 6 ] 3 , centrifuge the solution at a centrifugal rate of 5000r / min for 15min and redisperse it in 40mL volume water;

[0051] (2) Prepare 5mM K 3 Fe(CN) 6 and 5mM CuCl 2 Aqueous solution was simultaneously injected into Au@Co at a rate of 200 μL / min 2 [Fe(CN) 6 ] 3 In the aqueous solution, centrifuge the solution at a centrifugal rate of 5000r / min for 15min and redisperse in 40mL ethanol solution;

[0052] (3) Prepare 0.8M NaOH aqueous solution and add 30mL to the above ethanol solution, and obtain Cu(OH) after ultrasonication for 30...

Embodiment 3

[0056] (1) Prepare 40mM K 3 Fe(CN) 6 and 40mM CoCl 2 The aqueous solution was simultaneously injected into the reaction vessel at a rate of 600 μL / min to generate Co 2 [Fe(CN) 6 ] 3 ; Prepare 1mM HAuCl 4 aqueous solution and injected Co at a rate of 400 μL / min 2 [Fe(CN) 6 ] 3 solution, stirred for 30min; then prepared 7mM C 6 h 8 o 6 aqueous solution and added reduced HAuCl at a rate of 500 μL / min 4 , generating Au@Co 2 [Fe(CN) 6 ] 3 , centrifuge the solution at a centrifugal rate of 3000r / min for 10min and redisperse it in 60mL volume water;

[0057] (2) Prepare 20mM K 3 Fe(CN) 6 and 20mM CuCl 2 Aqueous solution was simultaneously injected into Au@Co at a rate of 300 μL / min 2 [Fe(CN) 6 ] 3 In the aqueous solution, centrifuge the solution at a centrifugal rate of 3000r / min for 10min and redisperse in 30mL ethanol solution;

[0058] (3) Prepare 0.4M NaOH aqueous solution and add 40mL to the above ethanol solution, and obtain Cu(OH) after ultrasonication for...

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Abstract

The invention discloses a core-shell hollow Cu(OH)2@Au@Co(OH)2 composite material as well as a preparation method and application thereof. The microstructure of the product is controlled by adjustingthe injection rate of a raw material liquid, a synthesized precursor Cu2[Fe(CN)6]3@Au@Co2[Fe(CN)6]3 has a regular cubic morphology, nano gold particles are uniformly distributed at the core-shell interface, and the conductivity of the composite material is remarkably improved. NaOH with different concentrations is used for etching the precursor, and the generated Cu(OH)2@Au@Co(OH)2 crystal has a three-dimensional nano flower-like morphology, a large specific surface area and multiple catalytic sites. An electrochemical sensor prepared from the Cu(OH)2@Au@Co(OH)2 composite material is suitablefor enzyme-free detection of glucose in serum, and has the advantages of high sensitivity, strong stability and good selectivity.

Description

technical field [0001] The invention relates to the technical field of electrochemical sensors, in particular to a core-shell hollow Cu(OH) 2 @Au@Co(OH) 2 Composite materials, preparation methods and applications. Background technique [0002] According to the report of the World Health Organization, it is estimated that by 2030, the number of diabetic patients will reach 578 million person-times. However, so far, no drugs that can directly treat the symptoms have been developed. If the blood sugar level cannot be controlled in time, diabetes will lead to many terrible complications such as kidney failure, cataract and cerebral thrombosis. Therefore, real-time monitoring of blood sugar levels is an effective means of prevention at present. Among the many types of glucose sensors, electrochemical sensors have always been a research hotspot due to their fast response, high sensitivity, easy operation and easy miniaturization. [0003] Electrochemical glucose sensors can b...

Claims

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Application Information

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IPC IPC(8): B01J23/89G01N27/327G01N31/10
CPCB01J23/8926G01N27/3278G01N31/10B01J35/397B01J35/23B01J35/33
Inventor 王毅姜丹锋张庆文
Owner WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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