Preparation method of doxycycline intermediate 11[alpha]-chloromethene oxytetracycline

The technology of chloromethicillin and chlorooxytetracycline is applied in the field of preparation of doxycycline intermediate 11α-chloromethicillin, which can solve the trouble of molecular sieve activation, the inability of molecular sieve to effectively activate and produce The process is cumbersome and other problems, to achieve the effect of reducing potential safety hazards, reducing environmental pressure, and high dehydration yield
CN111362826AActive Publication Date: 2020-07-03SHANDONG GUOBANG PHARMA +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG GUOBANG PHARMA
Publication Date
2020-07-03

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Abstract

The invention relates to the technical field of veterinary drugs, in particular to a preparation method of doxycycline intermediate 11[alpha]-chloromethene oxytetracycline. According to the preparation method, 11[alpha]-chloromethene oxytetracycline is taken as a raw material, dichloromethane is used as a solvent, and 1,1-dichloromethyl-N,N-dimethylamine is taken as a dehydrating agent to carry out reactions to obtain 11[alpha]-chloromethene oxytetracycline. By utilizing the preparation method, the production potential safety hazard can be reduced, the product yield is high, the generated waste salt is reduced, and the equipment type selection requirement is reduced.
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Description

technical field

[0001] The invention relates to the technical field of veterinary medicine, in particular to a preparation method of doxycycline intermediate 11α-chloromethycin. Background technique

[0002] Doxycycline is an antibiotic drug, a tetracycline drug, that can treat chlamydia mycoplasma infection. It is mainly used for the treatment of respiratory, urinary tract and biliary tract infections caused by sensitive bacteria. Upper respiratory tract infection, tonsillitis, biliary tract infection, lymphadenitis, cellulitis, senile chronic bronchitis, etc. caused by sensitive gram-positive bacteria and gram-negative bacilli. Pneumonia, etc. It can still be used to treat cholera, and also to prevent falciparum malaria and leptospirosis infection. Therefore, this drug is widely used in veterinary medicine, and the market demand is very large. The preparation of doxycycline generally uses oxytetracycline as a raw material, which is dehydrated by chlorination and hydrog...

Claims

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