28 results about "Oxytetracyclinum" patented technology

The invention discloses a preparation method of a portable paper-based ratiometric fluorescence sensor APBA-CsPbBr3 at-UiO-66 / Ru, which comprises the following steps: 1, adding lead bromide and cesium bromide into N, N-dimethylformamide, then adding 5-bromovaleric acid and an oleylamine ligand, and stirring; 2, perfluorooctyltriethoxysilane is added, and a precursor solution is obtained; 3, adding zirconium chloride and terephthalic acid into N, N-dimethylformamide to obtain a homogeneous solution; 4, after heating, UiO-66 is obtained; 5, stirring the precursor solution, APBA, UiO-66 and tris (2, 2-dipyridyl) ruthenium chloride hexahydrate to obtain a composite material; and 6, dropwise adding the composite material solution into the filter paper. The APBA modified material is adopted as a recognition unit, the APBA modified material and the paper base construct a fluorescence sensing platform, visual quantitative analysis of oxytetracycline in water is achieved, and the device is convenient to carry, low in detection limit, high in anti-interference performance, easy and convenient to operate and suitable for on-site rapid detection of oxytetracycline.

The invention discloses a construction method of an aptamer modified photonic crystal sensor for visually detecting oxytetracycline, and belongs to the technical field of sensing. In the invention, a photonic crystal array obtained by a vertical evaporation self-assembly method is combined with polyacrylamide hydrogel to form the photonic crystal hydrogel membrane material. Gold nanoparticles serve as a bridge, one side of each gold nanoparticle is connected with an amide framework of the hydrogel through chelation, the other side of each gold nanoparticle is connected with the oxytetracycline aptamer through covalent bonding, and the aptamer modified photonic crystal sensor is constructed. The oxytetracycline aptamer and oxytetracycline are highly selectively combined through pi-pi stacking and hydrogen bonds, so that the hydrogel swells, the lattice spacing of the photonic crystal is increased, a reflected signal and a structural color are subjected to red shift, and high-selectivity detection of the oxytetracycline is realized. The rapid detection requirements in the fields of food safety, environment monitoring, biological medicine and the like are met. The linear range of oxytetracycline detection is 0.1 mu g / mL-80 mu g / mL, and the lowest detection limit is 0.033 mu g / mL.

The invention discloses an aptamer-based oxytetracycline fluorescent quantitative PCR (Polymerase Chain Reaction) detection kit as well as a preparation method and a detection method thereof, and relates to the technical field of analysis and detection.The detection method comprises the following steps: mixing and incubating a sample to be detected, an oxytetracycline specific aptamer, a complementary chain and a magnetic bead curing capture probe; magnetically separating out the mixed and incubated magnetic beads, curing and capturing the probe, and washing to obtain a magnetic compound; adding PCR reaction liquid containing the primer pair and a TaqMan probe into the magnetic compound, carrying out fluorescent quantitative PCR amplification, and monitoring a fluorescent signal in real time to obtain a Ct value; establishing a standard curve between the oxytetracycline concentration and the Ct value of the fluorescent quantitative PCR, and determining the oxytetracycline concentration in the sample to be detected according to the standard curve. Based on an indirect competitive mechanism, through signal conversion design, combination of oxytetracycline and the aptamer is converted into quantitative analysis of free sDNA, and through integration of three technologies of aptamer free recognition, magnetic bead targeted capture and qPCR signal amplification, the sensitivity and anti-interference capability of oxytetracycline detection are improved.

The invention relates to the technical field of medicine processing, in particular to an improved oxytetracycline hydrochloride drying device which comprises a drying barrel, a drying mechanism, a transmission belt and a recycling mechanism, the drying mechanism is arranged on the inner side of the drying barrel, and the recycling mechanism communicates with the top of the drying barrel; and the transmission belt sleeves the front side of the surface of the recycling mechanism and the front side of the surface of the drying mechanism. The improved oxytetracycline hydrochloride drying device provided by the invention has an integrated structure of continuously and uniformly conveying heat flow to oxytetracycline hydrochloride, drying and stirring, so that stirring can be performed while the oxytetracycline hydrochloride is conveyed and dried, and the flexibility of oxytetracycline hydrochloride drying treatment is improved; and a waste gas circulating condensation impurity removal and recovery structure synchronous with stirring is arranged, so that circulating condensation impurity removal and recovery can be carried out on waste gas while oxytetracycline hydrochloride is dried and stirred, and the recovery and treatment efficiency of the waste gas generated during oxytetracycline hydrochloride drying is improved.

The invention provides a nucleic acid molecule capable of being combined with oxytetracycline in a high-affinity mode. The nucleic acid molecule can detect the oxytetracycline with high sensitivity after being labeled with a fluorescent dye. Nucleic acid molecules (SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 or SEQ ID NO: 5) capable of specifically recognizing oxytetracycline are used as affinity ligands, and sensitive detection of oxytetracycline is realized by using nucleic acid molecules marked with fluorescent dye. According to the detection method disclosed by the invention, the detection limit of oxytetracycline reaches nM level, and the sensitivity is high.

The application discloses a high-stability and low-irritation oxytetracycline long-acting injection and a preparation method thereof. 2+ EDTA-2Na and sodium formaldehyde bisulfite are coordinated to stabilize, and forsythia extract reduces irritation; the pH of the finished product is 8.2-8.8. The method comprises acid pre-coordination, pre-filtration, ultrafiltration, reduction and deoxygenation (dissolved oxygen is less than or equal to 2 ppm) and 0.22 mu m terminal sterile filtration. The application realizes long-term clarification and content stability under high loading, and inhibits metal catalytic oxidation and alkali-sensitive degradation.

The invention discloses an electrochemical aptamer sensor as well as a preparation method and application thereof. The electrochemical aptamer sensor comprises a substrate, a conductive enhancement layer and an anti-fouling biological recognition layer which are sequentially stacked, the conductive enhancement layer comprises a gold nanostar material; the anti-fouling biological recognition layer comprises a zwitterionic polymer and a sulfhydrylated oxytetracycline aptamer; the zwitterionic polymer is composed of a structural unit as shown in a formula 1, wherein the formula 1 is shown in the description. In the electrochemical aptamer sensor, a sensing interface is constructed by synergistically modifying the gold nanostars and the zwitterionic polymer. Wherein the gold nanostars are stably combined with the zwitterionic polymer and the OTC aptamer through Au-S bonds on the surface while enhancing a current signal by virtue of the high specific surface area and excellent conductivity of the gold nanostars; the zwitterionic polymer endows the interface with remarkable anti-fouling performance, and non-specific adsorption can be effectively inhibited, so that the pretreatment process is greatly simplified in complex sample detection, and the detection reliability is improved.

The invention discloses an oxytetracycline detection and removal double-effect integrated composite material and a preparation method thereof, and belongs to the technical field of environmental remediation and drug residue treatment.The preparation method comprises the steps that firstly, ZIF-8 is subjected to acid etching, and ZIF-8 of a cavity structure is obtained; the preparation method comprises the following steps: preparing ZIF-8 with a cavity structure, then injecting fluorescein into a cavity of the ZIF-8 with the cavity structure, then growing a ZIF-8 shell layer on the surface of the ZIF-8, and loading CDs-Eu < 3 + > in situ to obtain the terramycin detection and removal double-effect integrated composite material. Target molecules can be accurately recognized in complex matrixes (such as water, soil and food), the anti-interference performance is high, and the detection limit is low.

The invention discloses a flash evaporation drying method for oxytetracycline alkali wet crystals. According to the method, a flash dryer is adopted for treatment; the inner wall of the main machine is of a spiral sleeve layer structure, and a crushing and stirring device is arranged at a central shaft; the crushing and stirring device is composed of a horizontal crushing and stirring cutter, a vertical crushing and stirring cutter and an inclined crushing and stirring cutter. Through the synergistic effect of the spiral jacket layer structure and the crushing and stirring cutter, materials from top to bottom are crushed and thrown to the wall of the crusher, the effects of strengthening crushing and accelerating drying are achieved, the problems that in a traditional drying process, metal is left, the crystal form of a product is prone to being damaged, and the color becomes deep are solved, and the crushing efficiency and the drying efficiency can be remarkably improved; meanwhile, the contact time of heat-sensitive substances in the materials and hot air flow is shortened, generation of related substances is reduced, the product quality is improved, the requirement and consumption of heat energy are reduced, and energy conservation and environment protection are achieved.

The invention belongs to the technical field of veterinary oxytetracycline hydrochloride preparations, and provides a veterinary oxytetracycline hydrochloride orally disintegrating tablet and a preparation method thereof, the veterinary oxytetracycline hydrochloride orally disintegrating tablet comprises the following components by weight: 20-30% of oxytetracycline hydrochloride, 18-21% of a disintegrating agent, 48-52% of a filler, 2-4% of a lubricant, and 2-4% of a flavoring agent; wherein the disintegrating agent is composed of polyvinylpolypyrrolidone and low-substituted hydroxy propyl cellulose in a mass ratio of (1.5-3): 1, the filling agent is composed of a mixed auxiliary material and mannitol in a mass ratio of (2-4): 1, and the mixed auxiliary material is composed of microcrystalline cellulose and low-substituted hydroxy propyl cellulose in a mass ratio of (7-8): (2-3); the lubricant is prepared from superfine silica powder and magnesium stearate in a mass ratio of (1-5): 1, and the flavoring agent is prepared from stevioside and edible essence in a mass ratio of (4-6): 1. According to the technical scheme, the problems that in the prior art, a common tablet needs to be swallowed, the bitter taste is obvious, consequently, animals refer to eat, young livestock / poultry are difficult to take, gastrointestinal dissolution is slow, and the bioavailability is low are solved.

This invention belongs to the field of oxytetracycline photocatalytic degradation technology, and particularly relates to an InZrO3-O4 ... x / Carbon nitride catalyst, its preparation method, and its application. The InZrO... x / Carbon nitride catalyst consists of carbon nitride, InZrO x A highly efficient ternary composite photocatalytic system was constructed by combining InZrO, and the InZrO content was further optimized. x The loading and In / Zr molar ratio design optimizes the band structure matching, while providing more abundant surface active sites, improving photocatalytic activity and enhancing catalyst stability. It is suitable for anhydrous, high-efficiency solar-driven degradation of oxytetracycline-containing materials and has the potential for large-scale application.

The invention belongs to the technical field of doxycycline, and particularly relates to a veterinary drug doxycycline composition and a preparation process thereof, the veterinary drug doxycycline composition comprises 24%-26% of methanol, 3.5%-6.5% of oxytetracycline base, 0.03%-0.1% of methanol ammonia, 1.7%-3.2% of NBS, 24%-26% of 11 alpha-bromine-6, 12-hemiketal oxytetracycline, 7%-8% of HZSM-5, 24%-26% of toluenesulfonic acid and 3%-4% of palladium on carbon, the veterinary drug doxycycline composition further comprises catalysts, the catalysts comprise 2.7%-3.2% of titanium tetraisopropylate and 3.07%-4% of S-diphenol, and the reaction temperature is controlled to be 30-50 DEG C; the preparation method comprises the following steps: sequentially putting 100g of methanol, 10g of oxytetracycline base and 0.1 g of methanol ammonia into a reaction bottle, stirring for 30 minutes in an environment of 20-30 DEG C by using an ultrasonic stirrer, starting to cool to-10 to-15 DEG C, adding 5g of dried and crushed NBS, and carrying out dechlorination and asymmetric hydrogenation by using a self-made palladium-carbon catalyst, so that the yield and the chemical and stereoselectivity of the reaction are remarkably improved, the total yield reaches 53%, and the yield is up to 90%. The method has the advantages of high yield, good product quality and the like, and the doxycycline primary liquid is heated by heating equipment and lasts for a fixed time, so that the drug property of the doxycycline primary liquid is enhanced at a specific temperature, and the adverse reaction of drugs to animals is reduced.

The application belongs to the technical field of separation, and particularly relates to a terramycin hydrochloride crystallization device and a working method thereof. The terramycin hydrochloride crystallization device comprises: a feeding mechanism arranged on a crystallization mechanism, the feeding mechanism being in communication with the crystallization mechanism, and raw materials being crystallized in the crystallization mechanism after entering the crystallization mechanism through the feeding mechanism; a plurality of feeding flow channels are arranged in the feeding mechanism, and a filter bag is arranged in each feeding flow channel; a cleaning mechanism is arranged outside the feeding mechanism, the cleaning mechanism comprises a cleaning assembly corresponding to the filter bag, an air outlet of the cleaning assembly is located above an inner bottom surface of the corresponding filter bag, the cleaning assembly is suitable for blowing impurities on the inner bottom surface of the filter bag, and the cleaning assembly avoids that the air outlet of the cleaning assembly is blocked, so that the situation that the inner diameter of the inner pipeline is reduced or blocked, and the air output and the air output range are affected is avoided.

This invention discloses a method for removing oxytetracycline from water using boron nitride-modified copper ferrite-activated periodate. The catalytic material uses copper ferrite as the main material and boron nitride as a modifying material, wherein the mass ratio of boron nitride to copper ferrite is 1:5–20. The catalytic material used in this invention promotes charge transfer through surface support and the formation of interfacial Fe-N bonds, thereby achieving excellent oxytetracycline removal performance. The method for removing oxytetracycline from water using boron nitride-modified copper ferrite-activated periodate described in this invention has advantages such as low cost, simple operation, stable catalytic performance, wide applicable pH range, strong anti-interference ability, and high oxytetracycline removal efficiency, and has a promising application prospect for oxytetracycline wastewater treatment.

The invention discloses an oxytetracycline injection production degerming and filtering device, and relates to the technical field of oxytetracycline injects.The technical scheme is that the oxytetracycline injection production degerming and filtering device comprises a bottom plate, a storage box is fixedly embedded in the bottom plate, a discharging pipe is fixedly embedded in the bottom of the storage box, one side of the storage box is fixedly connected with a connecting plate and a connecting block, and the connecting block is located at the bottom of the connecting plate; and the shell is arranged outside the discharging pipe in a sleeving manner, and a mounting plate I is fixedly arranged outside the shell in a sleeving manner. The device has the beneficial effects that the sealing gasket can play a role in primary sealing, and in addition, the annular air cushion can be inflated to bulge, so that the annular air cushion can be in contact with the rubber ring, and then double sealing is realized; when the annular air cushion is inflated, the sealing gasket can be inflated to enable the sealing gasket to bulge, so that the sealing effect between the sealing gasket and the discharging pipe is improved, the sealing performance can be qualitatively improved by matching with double sealing, and then liquid is prevented from escaping from a gap between the sealing gasket and the discharging pipe.

The application provides a method for simultaneously determining the contents of two main drugs in oxytetracycline carprofen injection, and is applied to the technical field of content determination. The method belongs to high performance liquid chromatography, and comprises the selection of liquid chromatography conditions, the preparation of a reference solution, the preparation of a test solution and the determination of a sample. The specific process of gradient elution in the determination of the sample is carried out by using a mixed mobile phase composed of mobile phase A and mobile phase B at 0-7 minutes, 10-15 minutes and 20-25 minutes. The mixed mobile phase at 0-7 minutes and 20-25 minutes comprises 80% of mobile phase A and 20% of mobile phase B in volume ratio; the mixed mobile phase at 10-15 minutes comprises 40% of mobile phase A and 60% of mobile phase B in volume ratio. The contents of the two main drugs of oxytetracycline and carprofen can be simultaneously determined by using the same liquid chromatography condition, the operation complexity of the original method is reduced, and the detection efficiency is improved.

The invention relates to oxytetracycline hydrochloride soluble powder with high water solubility and high stability. The oxytetracycline hydrochloride soluble powder is mainly prepared from the following raw materials in percentage by weight: 20-50% of oxytetracycline hydrochloride, 10-30% of a stabilizer, 10-20% of a catalyst, 1-5% of a strong chelating agent and the balance of a filler. The oxytetracycline hydrochloride is used as an active component, the organic acid provides an acid environment, the acid catalyst and the organic acid form a hydrogen bond network to improve the instantaneous dissolvability, the metal ion chelating agent and the saccharide are used as stable carriers and are mixed in the double-cone rotary mixer, the process operation is convenient, and the production cost is effectively reduced. According to the formula, the drug solubility and the drug stability are effectively improved.

The present disclosure relates generally to methods and systems for controlling citrus greening disease in citrus plants, including for example orange trees.

The invention relates to the technical field of veterinary drug preparations, and discloses a preparation method of a high-content oxytetracycline hydrochloride injection, which comprises the following steps: dissolving nicotinamide in a mixed solvent of dimethylacetamide and water in a weight-volume ratio of 40.0-60.0%, and adding sodium formaldehyde sulfoxylate; adding magnesium oxide and uniformly dispersing; controlling the temperature, adding oxytetracycline hydrochloride in batches, and dropwise adding monoethanolamine to control the pH value of the process and the end point to 8.0-8.5; raising the temperature of the feed liquid to 50-60 DEG C and carrying out constant-temperature reaction until the feed liquid is clarified; and then cooling, fixing the volume and filtering. Through the synergistic effect of nicotinamide and thermal excitation, the polymerization path of oxytetracycline and a magnesium complex is blocked by utilizing a competitive coordination mechanism, so that the problems that high-concentration liquid medicine is high in viscosity and poor in needle passing performance are effectively solved; meanwhile, a reduction system and accurate pH control are matched, so that the chemical stability and physical stability of the preparation are improved, and low viscosity and long-acting stability of the high-content oxytetracycline injection are realized.

The invention discloses an oxytetracycline injection and a preparation method thereof, and the oxytetracycline injection is prepared from the following components in parts by weight: 18 to 22 parts of oxytetracycline, 35 to 50 parts of polyethylene glycol 400, 0.4 to 0.6 part of sodium formaldehyde sulfoxylate, 1.6 to 1.8 parts of magnesium oxide, 40 to 60 parts of acetamide, 0.5 to 1.5 parts of sodium formaldehyde sulfoxylate, 20 to 30 parts of oxytetracycline hydrochloride and 1.8 to 2.5 parts of magnesium oxide. The oxytetracycline is prepared by adding an oxytetracycline raw material into a methanol aqueous solution, dropwise adding hydrochloric acid to dissolve, adding modified activated carbon to remove impurities, filtering, dropwise adding ammonia water into the obtained filtrate, crystallizing, filtering and drying, and the oxytetracycline injection prepared by the preparation method disclosed by the invention is relatively high in product purity and relatively low in visible foreign matter content, and the amount of integrally used pyrrolidone is relatively small; the irritation is relatively low.

The invention provides an oxytetracycline-based quadrangular prism and a synthesis method thereof, manganese chloride and sodium sulfide are added into water to form an aqueous solution, oxytetracycline is added, a reaction is carried out under stirring, a micron-sized quadrangular prism is prepared, and the material contains manganese and sulfur besides oxytetracycline, is in a regular quadrangular prism shape, has good dispersity and stability, and can be used for preparing an oxytetracycline-based quadrangular prism material. The synthesis method is simple in step and easy in process control, high-temperature and high-pressure conditions and expensive solvents are not used, nitrate and nitrite can be quickly removed in nitrate wastewater treatment, an excellent effect is shown, and the method has a wide application prospect in the field of environmental protection.

The invention provides a construction method of a three-color photonic crystal sensor for environmental detection of oxytetracycline. The preparation method comprises the following steps: step 1, preparing monodisperse silicon dioxide microspheres with different sizes; and 2, constructing the three-color photonic crystal sensor on the same substrate through a step-by-step vertical sedimentation method. According to the novel three-color photonic crystal sensor constructed by the invention, the characteristic wavelength can be shifted to different degrees (R: 867-921nm; g: 723 to 771 nm; b: 548 to 601 nm), thereby generating three-color transition (R: light red to red; g: indigo blue-brick yellow; b: purple-blue), and high-precision visual detection of oxytetracycline in the high-ionic-strength water environment is realized. Meanwhile, within the logarithmic linear range of 0.1-80 [mu] g / mL, R2 of R / G / B channels is 0.966 / 0.956 / 0.992, and the on-site structural color change threshold (0.5 [mu] g / mL) meets the aquatic product safety standard. The multicolor photonic crystal sensor provides a new thought for constructing a field environment sensor with laboratory-level quantitative and instant visual reading functions.

The invention discloses an oxytetracycline hydrochloride preparation and purification process, and relates to the technical field of medical chemistry. The preparation and purification process comprises the following steps: catalyzing a compound a serving as an initial raw material and a compound b through piperidine to obtain a compound c; reacting the compound c with a compound d to obtain a compound e; reacting the compound e with a compound f to obtain a compound g; performing photochemical isomerization on the compound g to obtain a compound h oxytetracycline hydrochloride crude product; and purifying the compound h oxytetracycline hydrochloride crude product by using a choline-lactic acid eutectic solvent to obtain oxytetracycline hydrochloride. According to the micro-channel reactor, precise control over the three-dimensional configuration is achieved in the micro-channel reactor through a 365 nm UV light source, 365 nm photon energy is precisely matched with trans-configuration pi-to-pi electron transition energy, trans-configuration pi electrons can freely rotate, and a cis-structure is formed. The problem of stereoisomerization in chemical synthesis is solved, and the isomerization yield is increased to 90% or above.

The invention discloses dosing equipment for oxytetracycline production wastewater treatment, and relates to the technical field of wastewater treatment dosing, and the dosing equipment comprises a dosing device. According to the dosing equipment for oxytetracycline production wastewater treatment, through the design of the dosing device, chemicals enter the composite device, so that the effect of storing the chemicals is achieved, subsequent continuous operation is facilitated, the situation that the chemicals volatilize to affect the operation efficiency is prevented, and the composite device stirs the chemicals in the composite device, so that the effects of preventing precipitation and blockage and improving the reaction efficiency are achieved; a medicament enters a dosing shell through a composite device, sewage enters the dosing shell from a water inlet valve, a connecting shaft is controlled to rotate through a first motor, and a paddle plate is controlled to oppositely rotate on the upper side and the lower side through a double-reverse rotating shaft, so that the effect of stirring material liquid is achieved, and the effects of removing antibiotic residues and improving the efficiency are achieved. The pollutant concentration is reduced, sewage is prevented from being directly discharged, and the sewage flows outwards from one side of the water outlet valve, so that follow-up treatment and operation are facilitated.

The present invention relates to the field of catalytic oxidation technology, and in particular to a composition for the catalytic degradation of oxytetracycline and a preparation method thereof. The composition for the catalytic degradation of oxytetracycline is composed of the following raw materials in parts by weight: 5 to 15 parts of chemically modified biochar, 15 to 45 parts of ferrous salt, 10 to 30 parts of metal sulfide, 5 to 15 parts of natural polymer colloid, 4 to 8 parts of tin-based metal carbide or titanium-based metal carbide, and 1 to 2 parts of polyethyleneimine. The composition for the catalytic degradation of oxytetracycline prepared by the present invention, by acetylation of biochar, is loaded with more active functional groups, thereby improving the ability of H2O2 to oxidatively degrade OTC. The composition for the catalytic degradation of oxytetracycline prepared by the present invention, wherein the biochar is loaded with tin-based and titanium-based metals at the same time, can significantly enhance the ability of H2O2 to oxidatively degrade OTC at low concentrations, and further enhance the ability of H2O2 to oxidatively degrade OTC at high concentrations.

The utility model discloses a raw material feeding device for oxytetracycline production, and relates to the technical field of oxytetracycline production equipment, the raw material feeding device comprises a storage tank, the inner wall of the storage tank is provided with a feeding hopper, the inner wall of the feeding hopper is provided with a limiting rod, the outer wall of the limiting rod is provided with a reset spring, the bottom of the limiting rod is provided with a plug, and the plug is connected with the storage tank. And a fixed bracket is mounted at the top of the storage tank. By means of the storage tank, the feeding hopper, the limiting rod, the reset spring and the plug, materials needing to be supplemented are placed in the feeding hopper, at the moment, the plug is pushed upwards through the elastic force of the reset spring, the plug and the inner wall of the feeding hopper are sealed, and the materials needing to be supplemented can be temporarily stored; at the moment, the plug moves downwards, so that the plug is separated from the inner wall of the feeding hopper, the supplemented materials are discharged at the same time, multi-frequency material supplementing is avoided, and the material supplementing efficiency and the fermentation effect are improved.

A molybdenum disulfide / europium composite fluorescent probe and its preparation method and application belong to the field of rare earth fluorescent materials and the field of analytical detection of oxytetracycline. The specific scheme is as follows: The molybdenum disulfide / europium composite fluorescent probe is a composite of molybdenum disulfide nanosheets doped with europium. The composite shows, in terms of microstructure, that Eu2O3 is uniformly coated on flaky MoS2 nanosheets. The preparation method includes the following steps: Step 1, adding an aqueous L-cysteine solution to a Na2MoO4 solution and ultrasonically dispersing it uniformly to obtain liquid A; Step 2, dispersing Eu2O3 in water to obtain liquid B; Step 3, mixing liquids A and B, performing a hydrothermal reaction, cooling, and centrifuging to obtain the supernatant, which is the molybdenum disulfide / europium composite fluorescent probe. The probe has the advantages of simple preparation, good selectivity, low detection limit, and wide linear range, and can effectively overcome the interference of external environmental factors on the detection results.