Recombinant nucleic acid of seneca virus, recombinant vaccine strain as well as preparation method and application thereof

A recombinant nucleic acid, recombinant vaccine technology, applied in the field of genetic engineering, can solve problems such as indistinguishability, achieve high titer, achieve innovation, and achieve the effect of great application value
CN111394367AActive Publication Date: 2020-07-10LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
Publication Date
2020-07-10

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Abstract

The invention provides a recombinant nucleic acid of a seneca virus, a recombinant vaccine strain as well as a preparation method and application thereof and relates to the technical field of gene engineering. The invention provides a recombinant nucleic acid of a seneca virus, a seneca recombinant virus containing the recombinant nucleic acid, a seneca recombinant virus coded by the recombinant nucleic acid, a seneca recombinant vaccine strain containing the seneca recombinant virus as well as a preparation method and application of the seneca recombinant vaccine strain. According to the invention, the vaccine strain having the characteristics of high antigen productivity, remarkably reduced pathogenicity and even no pathogenicity for pigs, strong antibody response, high immune protectionrate and the like is prepared, and the vaccine strain remarkably improves the biosafety and may be used for preventing and controlling the seneca virus in China and surrounding countries.
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Description

technical field

[0001] The invention belongs to the technical field of genetic engineering, and in particular relates to a Seneca virus recombinant nucleic acid, a recombinant vaccine strain and a preparation method and application thereof. Background technique

[0002] Senecavirus A (Senecavirus A, SVA), also known as Senecavirus (Senecavirus), Seneca valley virus (Seneca valley virus, SVV), belongs to the small RNA virus family (Picornaviridae) Senecavirus genus (Senecavirus) ), the only member of the genus. The virus infects pigs and can cause primary vesicular disease in pigs, which is indistinguishable from clinical symptoms caused by foot-and-mouth disease, swine vesicular disease, and vesicular stomatitis. SVA infection can cause vesicular lesions in weaned piglets, nursery, fattening and breeding pigs of all ages, accompanied by clinical symptoms such as lameness, fever, anorexia, lethargy, etc. In addition to the above symptoms, newborn piglets may also have persis...

Claims

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