Gene-deleted attenuated African swine fever virus strain and application thereof

An African swine fever virus, African swine fever technology, applied in the field of bioengineering, can solve problems such as high cost, many knockout virulence genes, weakened strains reducing immunogenicity or protective effect, etc., to achieve good safety performance, promote The effect of interferon production
CN112063634AInactive Publication Date: 2020-12-11LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
Publication Date
2020-12-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of bioengineering, and particularly relates to a gene-deleted attenuated African swine fever virus strain with innate immune suppression and application. The invention finds that the ASFV MGF-505-7R can inhibit generation of interferon; an ASFV MGF-505-7R gene is deleted in an African swine fever original virulent strain to obtain the attenuated Africanswine fever virus strain with higher safety, thus providing a theoretical basis and practical reference for successful preparation of an African swine fever vaccine in the future. Further, a researchworker can finally prepare safe and effective African swine fever vaccine candidate strains by knocking out the ASFV MGF-505-7R and one or more disclosed virulence genes (such as CD2V, MGF360-12L, MGF360-13L, MGF360-14L, MGF360-505R and the like) simultaneously.
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Description

technical field

[0001] The invention belongs to the technical field of bioengineering, and in particular relates to a gene-deleted attenuated African swine fever virus strain and its application. Background technique

[0002] African swine fever (African swine fever, ASF) is caused by the infection of African swine fever virus (ASFV), and is characterized by fever and hemorrhage in pigs. The fatality rate for domestic pigs is as high as 100%. . The disease first broke out in Kenya in 1921 and subsequently became widespread among domestic and wild pigs throughout Africa. It was introduced into Europe in the 1950s, and it took 40 years to eliminate the disease throughout Europe. However, the disease was introduced to Georgia from East Africa again in 2007, and then spread widely in Eastern Europe, and in 2017, it was introduced to Irkutsk in the Russian Far East. In early August 2019, researcher Hu Rongliang took the lead in reporting the first case of African swine fever i...

Claims

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