Preparation method of albendazole dispersible tablets

A technology of albendazole and dispersible tablets, which is applied in the field of preparation of albendazole dispersible tablets, can solve the problems of affecting the effect of albendazole against echinococcosis, low bioavailability, and low drug concentration, and achieves a solution The effect of high viscosity of the material, increasing the dissolution rate and increasing the contact area

Inactive Publication Date: 2020-07-17
安徽圣鹰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Albendazole tablets, capsules and other dosage forms have been used clinically, but these dosage forms have poor intestinal absorption after oral administration, relatively low bioavailability, local drug concentration in lesions is not high, and individual differences are large. It affects the anti-hydatid effect of albendazole, so it is urgent to develop new dosage forms to improve its solubility, enhance targeting, and increase bioavailability

Method used

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  • Preparation method of albendazole dispersible tablets

Examples

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Comparison scheme
Effect test

Embodiment 1

[0024] This embodiment discloses a kind of preparation method of albendazole dispersible tablet, it is characterized in that: specifically comprise the following steps:

[0025] (1) Take the albendazole of 500g, put it into the grinder and grind it and pass through a 120 mesh sieve, dry it for subsequent use;

[0026] (2) Take 375g of polyvinylpyrrolidone and 250g of polyethylene glycol, mix them evenly, place them in a heating kettle, heat to 120-140°C, and keep stirring during the heating process until the polyvinylpyrrolidone and polyethylene glycol The diol is completely melted to obtain a carrier in a molten state;

[0027] (3) Under the condition of heating and stirring, add the ground albendazole into the molten carrier, speed up the stirring, so that the albendazole can be quickly dispersed in the carrier, and then transfer the dispersed mixture to -18°C Freeze in the freezing layer of the mixture, wait until it is completely frozen to a solid state, put the solid mix...

Embodiment 2

[0030] This embodiment discloses a kind of preparation method of albendazole dispersible tablet, it is characterized in that: specifically comprise the following steps:

[0031] (1) Take the albendazole of 500g, put it into the grinder and grind it and pass through a 120 mesh sieve, dry it for subsequent use;

[0032] (2) Take 250g of polyvinylpyrrolidone and 250g of polyethylene glycol, mix them evenly, place them in a heating kettle, heat to 120-140°C, and keep stirring during the heating process until the polyvinylpyrrolidone and polyethylene glycol The diol is completely melted to obtain a carrier in a molten state;

[0033] (3) Under the condition of heating and stirring, add the ground albendazole into the molten carrier, speed up the stirring, so that the albendazole can be quickly dispersed in the carrier, and then transfer the dispersed mixture to -18°C Freeze in the freezing layer of the mixture, wait until it is completely frozen to a solid state, put the solid mix...

Embodiment 3

[0036] This embodiment discloses a kind of preparation method of albendazole dispersible tablet, it is characterized in that: specifically comprise the following steps:

[0037] (1) Take the albendazole of 500g, put it into the grinder and grind it and pass through a 120 mesh sieve, dry it for subsequent use;

[0038] (2) Weigh 100g of polyvinylpyrrolidone and 100g of polyethylene glycol, mix them evenly, place them in a heating kettle, heat to 120-140°C, and keep stirring during the heating process until the polyvinylpyrrolidone and polyethylene glycol The diol is completely melted to obtain a carrier in a molten state;

[0039] (3) Under the condition of heating and stirring, add the ground albendazole into the molten carrier, speed up the stirring, so that the albendazole can be quickly dispersed in the carrier, and then transfer the dispersed mixture to -18°C Freeze in the freezing layer of the mixture, wait until it is completely frozen to a solid state, put the solid mi...

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Abstract

The invention relates to the technical field of preparation of medicaments, in particular to a preparation method of albendazole dispersible tablets. The method comprises the following steps: weighingand grinding albendazole, quickly mixing albendazole powder with melted polyvinylpyrrolidone and polyethylene glycol, placing obtained mixture in a freezing layer for freezing after uniform mixing, grinding frozen solid, adding a filler, a lubricant and a flavoring agent into obtained powder, placing obtained mixture in a three-dimensional mixer for mixing, and directly performing tabletting after the uniform mixing to obtain the albendazole dispersible tablets. The method overcomes the defects of the prior art, combines a combined carrier with the albendazole by adopting a melting way, greatly improves the dissolution rate of the albendazole, simplifies the production process and reduces the enterprise cost.

Description

technical field [0001] The invention relates to the technical field of preparation of medicaments, in particular to a method for preparing albendazole dispersible tablets. Background technique [0002] Albendazole is a broad-spectrum anthelmintic with high efficiency and low toxicity. It can be used clinically to drive away roundworms, pinworms, tapeworms, whipworms, hookworms, and strongyloid nematodes. It is rapidly metabolized into sulfoxide, sulfone alcohol and 2-amine sulfone alcohol in the body, selectively and irreversibly inhibits the polymerization of the cytoplasmic microtubule system of parasite intestinal wall cells to intestinal nematodes, and blocks its response to various nutrients and glucose. The ingestion and absorption of worms lead to the depletion of endogenous glycogen in the worms, and inhibit the fumarate reductase system, preventing the production of adenosine triphosphate, so that the worms cannot survive and reproduce. Similar to mebendazole, this...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/20A61K31/4184A61K47/36A61K47/32A61K47/10A61P33/10
CPCA61K31/4184A61K9/2027A61K9/2031A61K9/2059A61K9/2095A61K9/0056A61P33/10
Inventor 王娟冯辉陈正云张桂兰吕风玉李文欣
Owner 安徽圣鹰药业有限公司
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