Degradable magnesium alloy in-situ composite anastomotic nail and preparation method thereof

An in-situ composite and anastomotic nail technology, applied in the direction of nails, mechanical equipment, metal material coating technology, etc., can solve the problems of fast degradation rate, low mechanical strength, poor plasticity, etc., to promote the growth and protection of bones and teeth Nervous system, strengthening and plasticity-enhancing effects

Active Publication Date: 2020-07-17
SICHUAN MGALL MEDICAL DEVICES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a degradable magnesium alloy in-situ composite staple and its preparation method,

Method used

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  • Degradable magnesium alloy in-situ composite anastomotic nail and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] In this example, the preparation method of anastomotic nails: by weight percentage, pure magnesium, 1% Zn, 1% Nd are smelted into liquid metal, cast into ingots, surface defects and impurities are removed, and homogenized heat treatment is performed at 400 ° C for 4 hours , Magnesium alloy rods with a diameter of 10mm are processed by hot extrusion at 430°C (the extrusion ratio is 70:1), and wires with a diameter of 0.3mm are drawn by cold drawing, and heat treatment and annealing are performed at 300°C for 60min. The magnesium alloy wire is prepared into a U-shaped staple, the bending part of the U-shaped staple is elliptical, the total length of the staple is 10-15 mm, the height of the staple is 3-6 mm, and the diameter of the end surface of the staple is 0.20-0.35 mm. Staples are electrolytically polished to remove surface defects and impurities. The polishing liquid adopts a volume ratio of ethylene glycol ether: dehydrated alcohol: a mixed solution of phosphoric ac...

Embodiment 2

[0035] In this example, the preparation method of anastomotic nails: by weight percentage, pure magnesium, 1.73% Zn, 0.68% Nd are smelted into liquid metal, cast into ingots, surface defects and impurities are removed, and homogenization heat treatment is performed at 380°C for 6 hours , Magnesium alloy rods with a diameter of 10mm are processed by hot extrusion at 420°C (the extrusion ratio is 60:1), and wires with a diameter of 0.3mm are drawn by cold drawing, and heat treatment and annealing are performed at 280°C for 120min. The magnesium alloy wire is prepared into a U-shaped staple, the bending part of the U-shaped staple is elliptical, the total length of the staple is 10-15 mm, the height of the staple is 3-6 mm, and the diameter of the end surface of the staple is 0.20-0.35 mm. Staples are electrolytically polished to remove surface defects and impurities. The polishing liquid adopts a volume ratio of ethylene glycol ether: dehydrated alcohol: phosphoric acid=1:2:2 mix...

Embodiment 3

[0038] In this example, the preparation method of anastomotic nails: by weight percentage, pure magnesium, 1.6% Zn, 0.7% Nd are smelted into liquid metal, cast into ingots, surface defects and impurities are removed, and homogenized heat treatment is performed at 420°C for 5 hours , Magnesium alloy rods with a diameter of 10mm are processed by hot extrusion at 410°C (the extrusion ratio is 80:1), and wires with a diameter of 0.3mm are drawn by cold drawing, and heat treatment and annealing are performed at 320°C for 30min. The magnesium alloy wire is prepared into a U-shaped staple, the bending part of the U-shaped staple is elliptical, the total length of the staple is 10-15 mm, the height of the staple is 3-6 mm, and the diameter of the end surface of the staple is 0.20-0.35 mm. Staples are electrolytically polished to remove surface defects and impurities. The polishing liquid adopts a volume ratio of ethylene glycol ether: dehydrated alcohol: a mixed solution of phosphoric ...

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Abstract

The invention relates to the technical field of biomedical materials, and particularly provides a degradable magnesium alloy in-situ composite anastomotic nail and a preparation method thereof. The anastomotic nail is made of a composite structural material and mainly comprises two parts, wherein the inner part is composed of high-strength and good-plasticity Mg-Zn-Nd magnesium alloy, the outer part is composed of MgF2 playing a role in corrosion protection, and MgF2 is subjected to in-situ compounding to an outer layer of the Mg-Zn-Nd magnesium alloy anastomotic nail to form the anastomotic nail. The magnesium alloy composite material anastomotic nail has good plastic deformation capability and mechanical strength, slow degradation speed and excellent biological safety, meets the implantation requirement for the anastomotic nail in a body, can be degraded gradually in the body after a medical effect in the biological body is achieved, and avoids secondary operation for taking out thenail.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, and in particular provides a degradable magnesium alloy in-situ composite staple and a preparation method thereof. Background technique [0002] The existing titanium alloy nails are non-degradable and are foreign objects in the human body. Long-term residence can easily lead to adverse reactions such as inflammation, slow healing, sensitization, and carcinogenicity. When the patient's tissue is repaired or healed, the implanted device needs to be removed, requiring a second operation, which brings additional surgical risks, economic pressure and physical pain to the patient. [0003] Magnesium alloys are degradable, and the characteristics of magnesium that are prone to corrosion in the human environment are used to achieve the medical and clinical purpose of magnesium alloy implants gradually biodegrading in the body until they finally disappear. Compared with traditional implant m...

Claims

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Application Information

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IPC IPC(8): C22C23/06C22C1/02C22F1/06C25F3/18C23C22/34B21G3/18
CPCC22C23/06C22C1/02C22F1/06C25F3/18C23C22/34B21G3/18C22C23/04A61L31/022A61L31/088A61L31/148A61L31/14A61L2420/02
Inventor 马政谭丽丽杨柯
Owner SICHUAN MGALL MEDICAL DEVICES CO LTD
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