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Rhizoma smilacis glabrae and fructus mume composition and application thereof in treatment of psoriasis

The technology of tuckahoe and composition is applied in the field of traditional Chinese medicine composition for treating psoriasis, which can solve the problems of high cost, difficult quality control, difficult development and the like, and achieve the effect of good effect

Inactive Publication Date: 2020-07-28
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, most of them are large prescriptions containing multiple medicinal materials, which are difficult to develop due to high cost and difficult quality control. Therefore, people are still looking for safe and effective psoriasis treatment drugs and methods

Method used

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  • Rhizoma smilacis glabrae and fructus mume composition and application thereof in treatment of psoriasis
  • Rhizoma smilacis glabrae and fructus mume composition and application thereof in treatment of psoriasis
  • Rhizoma smilacis glabrae and fructus mume composition and application thereof in treatment of psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of oral liquid: mix Smilax smilax and ebony decoction pieces according to 5:1, add 10 times of water to decoct 3 times, 1.5h / time, combine the decoctions, let stand overnight, take the supernatant, decoct and concentrate to a constant volume, Add preservatives, stir well and filter, then subpackage and sterilize. Keep sealed and take orally.

Embodiment 2

[0033] Preparation of granules: mix smilax and ebony decoction pieces according to 5:3, add 10 times of water to soak for 0.5h, decoct 3 times, 2h / time, combine the decoction, let stand, filter, decoct and concentrate until the relative density is 1.25-1.30 (60°C) thick paste, dried under reduced pressure (70°C) to obtain dry paste powder. Dry cream powder and dextrin are mixed uniformly at a ratio of 1:1.5, then 85% ethanol solution is used as a wetting agent to make granules, and dried to obtain the product.

Embodiment 3

[0035] Preparation of tablets: Smilax ebony is crushed into 20-mesh coarse powder, soaked in 60% ethanol at 10 times the weight volume concentration, soaked for 30 minutes, extracted and refluxed twice, each time for 1 hour, combined extracts, concentrated into Baume The medicinal extract with a concentration of 1.3 is mixed with 100% starch by weight of the medicinal extract, granulated, dried, added with 3% magnesium stearate by weight of the medicinal extract, mixed uniformly, and pressed to form.

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Abstract

The invention discloses a rhizoma smilacis glabrae and fructus mume composition and application thereof in treatment of psoriasis. The rhizoma smilacis glabrae and fructus mume composition is preparedfrom raw materials including rhizoma smilacis glabrae and fructus mume in any ratio. Animal experiments prove that the rhizoma smilacis glabrae and fructus mume composition mainly shows the characteristics of being able to effectively relieve imiquimod-induced BABL / c mouse psoriatic lesion and improve pathological forms such as skin damage, scales and thickening of back sin of BABL / c mice, the PASI score of the BABL / c mice treated by the rhizoma smilacis glabrae and fructus mume composition is significantly lower than that of a model control group and is equivalent to that of a group using apositive control drug methotrexate, the efficacy of the rhizoma smilacis glabrae and fructus mume composition is superior to that of a rhizoma smilacis glabrae group and a fructus mume group, and therhizoma smilacis glabrae and fructus mume composition has a synergistic effect. Therefore, the rhizoma smilacis glabrae and fructus mume composition has significant therapeutic effects on the psoriasis and can be used for preparing a drug for treating the psoriasis. The rhizoma smilacis glabrae and fructus mume composition has better prevention or treatment effects on the psoriasis and is safe andnon-toxic.

Description

technical field [0001] The present invention relates to a kind of Chinese medicine composition for treating psoriasis, in particular to a kind of Chinese medicine composition for treating psoriasis. Background technique [0002] Psoriasis (psoriasis) is a common disease in dermatology, which is a chronic inflammatory proliferative disease with immune abnormalities determined by polygenic inheritance and stimulated by multiple environmental factors. Psoriasis often shows effect repeatedly, lingering and difficult to heal, and skin lesion involves whole body when serious, desquamation is serious, pruritus is unbearable, brings serious impact to patient's physical and mental health. [0003] Modern medicine uses local or systemic medication according to the degree of skin lesions. Treatments such as glucocorticoids, immunosuppressants, biological agents, and retinoic acid all have certain curative effects, but they are difficult to cure and easy to repeat. patient compliance. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/896A61P17/06
CPCA61K36/736A61K36/896A61K36/90A61P17/06A61K2300/00
Inventor 卢传坚赵瑞芝刘丽娟韩凌赵亚吴亚运
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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