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Dietary nutrition supplement for improving abnormal glucose metabolism caused by arsenic exposure and screening method of dietary nutrition supplement

A technology of nutritional supplements and screening methods, applied in the field of medicine, can solve the problems of destroying islet β cells, being unable to protect, increasing the risk of T2DM, etc.

Active Publication Date: 2020-07-31
NANJING MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Type 2 diabetes (T2DM) is often accompanied by damage to islet β cells, and increasing evidence shows that high arsenic exposure can damage islet β cells and increase the risk of T2DM
[0007] However, although there have been various studies and investigation results above, there is still no technical means to screen dietary supplements that can improve abnormal glucose metabolism caused by arsenic exposure, and there is no way to treat people who are exposed to arsenic. effective protection of people

Method used

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  • Dietary nutrition supplement for improving abnormal glucose metabolism caused by arsenic exposure and screening method of dietary nutrition supplement
  • Dietary nutrition supplement for improving abnormal glucose metabolism caused by arsenic exposure and screening method of dietary nutrition supplement
  • Dietary nutrition supplement for improving abnormal glucose metabolism caused by arsenic exposure and screening method of dietary nutrition supplement

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Embodiment

[0068] The present embodiment adopts the above-mentioned screening method, and the screening objects are composed of folic acid and vitamin B12, wherein the ratio of folic acid and vitamin B12 is 6 mg:50 μg; in specific use, the concentration of folic acid is 6 mg / L, and the concentration of vitamin B12 is 50 μg / L L.

[0069] 1. Materials and methods

[0070] 1.1 Reagents and instruments

[0071] Vitamin B12 and folic acid (sigma company), D-glucose anhydrous (sigma company). Roche’s excellent gold mining blood glucose meter and supporting blood glucose test strips (Germany Roche Blood Glucose Health Care Company), FX-2000iw electronic analytical balance (Japan Iande Company), HPLC / PS ultrapure water meter (Shanghai Jizhou Chemical Technology Co., Ltd.) .

[0072] 1.2 Experimental objects

[0073] A number of healthy adult SPF grade C57BL / 6J mice (8 weeks old), with a male to female ratio of 2:1, were fed maintenance feed and raised in the Animal Barrier Laboratory of a Ph...

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Abstract

The invention relates to a dietary nutrition supplement for improving abnormal glucose metabolism caused by arsenic exposure by a medicament and a screening method of the dietary nutrition supplement.The screening method comprises the following steps: performing arsenic exposure and intervention on F0-generation pregnant rats, detecting fasting blood glucose and glucose tolerance, and judging andscreening candidate medicaments; normally feeding F1-generation child mice, detecting fasting blood glucose and glucose tolerance, and judging and screening the candidate medicaments; and normally feeding F2-generation child mice, detecting fasting blood glucose and glucose tolerance, judging and screening the candidate medicaments, and taking the finally screened candidate medicaments as a dietary nutrition supplement for improving abnormal glucose metabolism caused by arsenic exposure. The dietary nutrition supplement is composed of folic acid and vitamin B12, and is used for preparing a diet, a drug or a pharmaceutical composition with an arsenic exposure protection effect. The screening method disclosed by the invention can be used for screening out the dietary nutrition supplement for effectively protecting individuals in an arsenic exposure environment. The dietary nutrition supplement for improving abnormal glucose metabolism caused by arsenic exposure not only can play a rolein protecting individuals in an arsenic exposure state, but also can play a role in protecting individuals in heredity.

Description

technical field [0001] The invention relates to a dietary nutritional supplement screening method for improving abnormal glucose metabolism caused by arsenic exposure, and a dietary nutritional supplement obtained thereby, which belong to the field of medical technology. Background technique [0002] As far as the applicant knows, arsenic (As) is a metalloid element that widely exists in nature, and arsenic has been recognized as a human carcinogen for more than a century. Medically, arsenic can be used to treat ulcers and acute promyelocytic leukemia. In addition, realgar and orpiment also contain arsenic as the main component. Therefore, humans can be exposed to inorganic arsenic (iAs) through the environment, occupational exposure, or the use of arsenic-containing drugs, and environmental arsenic exposure is the main route of human exposure to arsenic. In recent years, the hazards of environmental arsenic exposure have become more and more serious, mainly through arsenic...

Claims

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Application Information

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IPC IPC(8): A23L33/15A01K67/02A61K49/00
CPCA23L33/15A61K49/0008A01K67/02A23V2002/00A23V2200/328A23V2250/7056A23V2250/706
Inventor 张静姝顾晨曦刘起展王玉邦
Owner NANJING MEDICAL UNIV
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