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Furosemide oral solution and preparation method thereof

A technology for oral solution and furosemide, applied in the field of furosemide oral solution and preparation thereof, can solve the problems of little help, severe bitter taste of oral solution, numb taste buds that are difficult to dissipate, etc., achieving good compliance and easy taking Effect

Pending Publication Date: 2020-07-31
JIANMIN PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this way of dissolving makes the oral solution produce a severe bitter taste, which numbs the taste buds for a long time and is difficult to dissipate.
[0004] In addition, the patent CN200810237139.2 discloses a furosemide oral solution, which improves the taste only by simply adding a specific ratio of sweeteners and flavoring agents, and the effect is not very helpful.
In addition, this prescription is also difficult to maintain the long-term stability of Semide in aqueous solution

Method used

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  • Furosemide oral solution and preparation method thereof
  • Furosemide oral solution and preparation method thereof
  • Furosemide oral solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The present embodiment provides a furosemide oral solution, and the prescription composition is as shown in Table 1 below:

[0029] The furosemide oral solution composition table of table 1 embodiment 1

[0030]

[0031] The preparation method of the furosemide oral solution of the present embodiment may further comprise the steps:

[0032] Preparation of concentrated medicinal solution: Weigh furosemide, propylene glycol and potassium carbonate according to the composition of the concentrated medicinal solution in Table 1. Put potassium carbonate in an appropriate amount of purified water and stir to dissolve to obtain an alkaline solution. Add propylene glycol to the alkaline solution, stir and mix, then add furosemide, stir and dissolve to obtain a stable concentrated medicinal solution.

[0033] Prepare the flavoring solution: weigh sorbitol, hydroxyethyl cellulose, sodium saccharin, ethyl maltol and sunset yellow according to the composition of the flavoring s...

Embodiment 2

[0036] The present embodiment provides a furosemide oral solution prescription composition as shown in Table 2 below:

[0037] The furosemide oral solution composition table of table 2 embodiment 2

[0038]

[0039] The preparation method of the furosemide oral solution of the present embodiment may further comprise the steps:

[0040] Preparation of concentrated medicinal solution: Weigh furosemide, propylene glycol and potassium carbonate according to the composition of the concentrated medicinal solution in Table 2. Dissolve sodium carbonate in an appropriate amount of purified water and stir to obtain an alkaline solution. Add propylene glycol to the alkaline solution, stir and mix, then add furosemide, stir and dissolve to obtain a stable concentrated medicinal solution.

[0041] Prepare the flavoring solution: weigh sorbitol, sodium carboxymethylcellulose, aspartame, ethyl maltol and chocolate brown according to the composition of the flavoring solution in Table 2. ...

Embodiment 3

[0044] The present embodiment provides a furosemide oral solution, and the prescription composition is as shown in Table 3 below:

[0045] The furosemide oral solution composition table of table 3 embodiment 3

[0046]

[0047] The preparation method of the furosemide oral solution of the present embodiment may further comprise the steps:

[0048] Preparation of concentrated medicinal liquid: Weigh furosemide, propylene glycol and potassium carbonate according to the composition of the concentrated medicinal liquid in Table 3. Dissolve sodium carbonate in an appropriate amount of purified water and stir to obtain an alkaline solution. Add propylene glycol to the alkaline solution, stir and mix, then add furosemide, stir and dissolve to obtain a stable concentrated medicinal solution.

[0049] Prepare the flavoring solution: weigh sorbitol, sodium carboxymethylcellulose, aspartame, ethyl maltol and tartrazine according to the composition of the flavoring solution in Table ...

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Abstract

The invention relates to a furosemide oral solution and a preparation method thereof. The furosemide oral solution contains a cellulose derivative and a sweet synergist with specific contents, and iscompounded with furosemide, propylene glycol, a diluent, a sweetening agent and essence; and on the premise of ensuring long-term stability of a preparation, the astringent taste of the conventional furosemide oral solution can be improved into a smooth, fragrant, sweet and rich taste on the whole.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a furosemide oral solution and a preparation method thereof. Background technique [0002] Furosemide is a high-efficiency diuretic drug suitable for edema caused by various etiologies. It is the drug of choice for acute edema and has been included in the "List of the First Batch of Children's Drugs Encouraging R&D Application". [0003] At present, alkali and propylene glycol are added to the commercially available furosemide oral solution to promote the dissolution of furosemide to ensure the stability of furosemide in the solution after dissolution. However, this dissolution method makes the oral solution produce a severe bitter taste, and the numbness of the taste buds is difficult to dissipate for a long time. [0004] In addition, the patent CN200810237139.2 discloses a furosemide oral solution, which improves the mouthfeel only by simply adding a speci...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/26A61K47/38A61K47/10A61K31/341A61P7/10
CPCA61K9/0095A61K31/341A61K47/10A61K47/26A61K47/38A61P7/10
Inventor 余丽花任霞郭平吴雪英张梦婷黄佩闻
Owner JIANMIN PHARMA GRP CO LTD
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