Microcosmic electrical impedance imaging device and method based on diamond NV color center

A technology of electrical impedance imaging and color center, which is applied in the field of biological cell parameter measurement, can solve problems such as insufficient accuracy and stability of the solution algorithm, large image error, and insufficient repeatability.

What is AI technical title?
AI technical title is built by PatSnap AI team. It summarizes the technical point description of the patent document.
A technology of electrical impedance imaging and color center, which is applied in the field of biological cell parameter measurement, can solve problems such as insufficient accuracy and stability of the solution algorithm, large image error, and insufficient repeatability.

CN111504884AActive Publication Date: 2020-08-07UNIV OF SCI & TECH OF CHINA

13 Cites 6 Cited by

Image

Smart Image Click on the blue labels to locate them in the text.

Viewing Examples

Smart Image

Examples

Experimental program

Comparison scheme

Effect test

Embodiment Construction

[0037] The invention realizes a microscopic electrical impedance imaging method that is fast, stable, error controllable, has micron-scale spatial resolution, and is suitable for cells and subcellular structures. Combined with NV color center high-sensitivity and high-spatial-resolution magnetic field measurement technology, the spatial resolution of electrical impedance imaging is improved to the microscopic scale; a microelectrode device dedicated to cells is designed and manufactured, which can be used for conductivity imaging of cell samples; design And manufactured a PCB board with connectable leads, loaded voltage source, and broadband microwave radiation structure, which is used to control the quantum state of the NV color center in diamond. It is used in conjunction with the microelectrode device to complete the introduction of microwave radiation and load on cell samples. The function of voltage flowing into current; design and manufacture of microfluidic chip used in ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine

Login to View More

PUM

Login to View More

Abstract

A microcosmic electrical impedance imaging device based on a diamond NV color center comprises a magnetic field imaging module adopting a diamond ensemble NV as a weak magnetic field detector; a microwave radiation structure module which adopts an omega-shaped radiation structure as a microwave antenna to radiate a microwave magnetic field to the diamond NV color center; a microelectrode module which is used for injecting alternating current into the buffer solution by adopting a cross-shaped iridium-iridium oxide metal electrode with two pairs of electrode arms. According to the invention, the spatial resolution of the existing magnetic resonance electrical impedance imaging is expanded, and the spatial resolution of the electrical impedance imaging is improved to a micron scale to a submicron scale, so an electrical impedance imaging method on a microcosmic scale is realized, and the method is suitable for conductivity imaging of a cell biological sample.

Description

technical field [0001] The invention relates to the technical field of biological cell parameter measurement, in particular to a microscopic electrical impedance imaging device and method based on diamond NV color centers. Background technique [0002] The cell membrane does not conduct electricity, and the cytoplasm and the liquid environment of the cell contain electrolyte solution, which is conductive. Physiological and pathological states of cells will change the permeability of the cell membrane, causing changes in the electrical impedance of the cell (which degenerates into conductivity at low frequency approximations) and its distribution. The electrical impedance of cells or biological tissues reflects the physiological state of cells, and the electrical impedance imaging of biological tissues has important application value in medical diagnosis and biomedical research. Especially in the diagnosis of cancer, imaging the conductivity of biological samples can provide...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine

Login to View More

Application Information

Patent Timeline

07 Aug 2020

Publication

CN111504884A

IPC: G01N15/10

CPC: G01N15/1031

Inventors: 李春兴; 王鹏飞