Microcosmic electrical impedance imaging device and method based on diamond NV color center

A technology of electrical impedance imaging and color center, which is applied in the field of biological cell parameter measurement, can solve problems such as insufficient accuracy and stability of the solution algorithm, large image error, and insufficient repeatability.

Active Publication Date: 2020-08-07
UNIV OF SCI & TECH OF CHINA
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Problems solved by technology

[0007] The disadvantage is that the spatial resolution of this conductivity imaging method is usually a few millimeters, which is suitable for conductivity imaging at the macroscopic scale of tissues and organs, but is no longer suitable for microscopic conductivity imaging at the cellular or subcellular level.
This limits the further application of conductivity imaging in disease diagnosis and biomedical research
In addition, according to the actual measurement r...

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  • Microcosmic electrical impedance imaging device and method based on diamond NV color center
  • Microcosmic electrical impedance imaging device and method based on diamond NV color center
  • Microcosmic electrical impedance imaging device and method based on diamond NV color center

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Embodiment Construction

[0037] The invention realizes a microscopic electrical impedance imaging method that is fast, stable, error controllable, has micron-scale spatial resolution, and is suitable for cells and subcellular structures. Combined with NV color center high-sensitivity and high-spatial-resolution magnetic field measurement technology, the spatial resolution of electrical impedance imaging is improved to the microscopic scale; a microelectrode device dedicated to cells is designed and manufactured, which can be used for conductivity imaging of cell samples; design And manufactured a PCB board with connectable leads, loaded voltage source, and broadband microwave radiation structure, which is used to control the quantum state of the NV color center in diamond. It is used in conjunction with the microelectrode device to complete the introduction of microwave radiation and load on cell samples. The function of voltage flowing into current; design and manufacture of microfluidic chip used in ...

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Abstract

A microcosmic electrical impedance imaging device based on a diamond NV color center comprises a magnetic field imaging module adopting a diamond ensemble NV as a weak magnetic field detector; a microwave radiation structure module which adopts an omega-shaped radiation structure as a microwave antenna to radiate a microwave magnetic field to the diamond NV color center; a microelectrode module which is used for injecting alternating current into the buffer solution by adopting a cross-shaped iridium-iridium oxide metal electrode with two pairs of electrode arms. According to the invention, the spatial resolution of the existing magnetic resonance electrical impedance imaging is expanded, and the spatial resolution of the electrical impedance imaging is improved to a micron scale to a submicron scale, so an electrical impedance imaging method on a microcosmic scale is realized, and the method is suitable for conductivity imaging of a cell biological sample.

Description

technical field [0001] The invention relates to the technical field of biological cell parameter measurement, in particular to a microscopic electrical impedance imaging device and method based on diamond NV color centers. Background technique [0002] The cell membrane does not conduct electricity, and the cytoplasm and the liquid environment of the cell contain electrolyte solution, which is conductive. Physiological and pathological states of cells will change the permeability of the cell membrane, causing changes in the electrical impedance of the cell (which degenerates into conductivity at low frequency approximations) and its distribution. The electrical impedance of cells or biological tissues reflects the physiological state of cells, and the electrical impedance imaging of biological tissues has important application value in medical diagnosis and biomedical research. Especially in the diagnosis of cancer, imaging the conductivity of biological samples can provide...

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Application Information

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IPC IPC(8): G01N15/10
CPCG01N15/1031
Inventor 李春兴王鹏飞刘东陈三友石发展王孟琪杜江峰
Owner UNIV OF SCI & TECH OF CHINA
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