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Preparation method of biochip based on silicon carbide substrate

A silicon carbide substrate and biochip technology, applied in biochemical equipment and methods, chemical instruments and methods, specific-purpose bioreactors/fermenters, etc., can solve the problem of long time for cancer detection results, delayed treatment time, High cost and other problems, to achieve the effect of being suitable for popularization and use, saving medical resources, and simple preparation process

Inactive Publication Date: 2020-08-11
哈尔滨鹏谦科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, cancer detection must rely on large-scale or non-portable detection instruments. After samples are collected, they must be sent to professional medical testing institutions for testing. Therefore, the time for cancer detection results is long and the cost is high. Many cancer patients cannot be found in the early stages of cancer. Delay the optimal treatment time

Method used

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  • Preparation method of biochip based on silicon carbide substrate
  • Preparation method of biochip based on silicon carbide substrate
  • Preparation method of biochip based on silicon carbide substrate

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Experimental program
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specific Embodiment approach 1

[0028] Specific implementation mode one: combine Figure 1-Figure 2 Describe this embodiment, a silicon carbide substrate-based biochip in this embodiment includes a graphene coating 1, a silicon carbide substrate base 2, and a biochip unit 3, and the graphene coating 1 is attached to the silicon carbide substrate On the substrate 2, the biochip unit 3 is integrated on the graphene coating 1, and the graphene coating 1 has strong conductivity. When the gene probe in the biochip unit 3 on the graphene reacts with the sample to be tested, it will A weak current will be generated.

specific Embodiment approach 2

[0029] Specific implementation mode two: combination Figure 1-Figure 3 Describe this embodiment, based on specific embodiment 1, a biochip based on a silicon carbide substrate in this embodiment, the biochip unit 3 includes a biochip system 3-1, a micropump 3-2, a plasma system 3- 3. Color recognition system 3-4, temperature control system 3-5, microwave cleaning system 3-6 and power supply system, biochip system 3-1, micropump 3-2, plasma system 3-3, color recognition system 3- 4. The temperature control system 3-5 and the microwave cleaning system 3-6 are integrated on the graphene coating 1,

[0030] A biochip based on a silicon carbide substrate is used in combination with a detection device. The color recognition system 3-4 reacts the color to the receiver of the detection device. The receiver receives the signal and responds to the terminal of the detection device. The detection device The advanced control system can analyze the data of the color recognition system, an...

specific Embodiment approach 3

[0031] Specific implementation mode three: combination Figure 1-Figure 3 This embodiment is described. A silicon carbide substrate-based biochip in this embodiment further includes a gene probe, which is arranged on the biochip system 3-1, and the gene probe is used to react with the sample to be tested.

[0032] Specific implementation mode four: combination Figure 1-Figure 3 Describe this embodiment, a biochip based on a silicon carbide substrate in this embodiment, the plasma system 3-3 is provided with a targeting probe, the targeting probe reacts with the sample to be tested, and the generated electrons change, and then through the action of the micropump 3-2, the current is transmitted to the power supply system to generate a change in the size and intensity of the current, which is reflected to the color recognition system 3-4, and the concentration of the sample to be tested is determined according to the change in color to achieve quantitative detection , The micro...

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Abstract

The invention relates to a preparation method of a biochip based on a silicon carbide substrate, and belongs to the field of the biochip. According to the invention, the biochip based on the silicon carbide substrate comprises a graphene laminating film, a silicon carbide substrate base and a biochip unit; the graphene laminating film is attached to the silicon carbide substrate base; and the biochip unit is integrated on the graphene laminating film. The preparation method of the biochip comprises: a step a of attaching the graphene laminating film to the silicon carbide substrate base; a step b of machining and producing a microfluidic channel on the silicon carbide substrate base machined in the step a by adopting cutting, grinding and polishing processes; a step c of fixedly mounting agene probe and a chemical modification unit on the microfluidic channel machined in the step b; and a step d of machining and producing the biochip unit on the graphene laminating film machined in the step c by adopting the cutting, grinding and polishing processes. The preparation method is ingenious in preparation step and simple in preparation process, and production efficiency is improved.

Description

technical field [0001] The invention relates to a method for preparing a biochip based on a silicon carbide substrate, belonging to the field of biochips. Background technique [0002] The mechanism of cancer is very complex. For different cancers or even patients with the same cancer, the molecular mechanisms and histopathological pathways leading to cancer are different. In the process of cancer treatment, only when the same disease is treated differently, and individualized treatment is implemented, can the appropriate drugs be selected for different types of patients. Therefore, cancer patients need to treat patients differently during the whole process from diagnosis to treatment. In order to carry out targeted and individualized treatment, multiple tests must be carried out in different periods and different parts. [0003] At present, cancer detection must rely on large-scale or non-portable detection instruments. After samples are collected, they must be sent to pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00C12M1/38C12M1/36C12M1/34C12Q1/6837B01L3/00
CPCC12Q1/6837B01L3/502707C12Q2565/629C12Q2563/103
Inventor 不公告发明人
Owner 哈尔滨鹏谦科技有限公司
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