Application of limonene in preparation of anti-allergic dermatitis drug

An anti-allergic, limonene technology, applied in the field of biomedicine, can solve the problems of weak curative effect, irritation, and poor curative effect, and achieve the effect of inhibiting allergic reaction, good therapeutic effect, and inhibiting mast cell degranulation

Inactive Publication Date: 2020-08-14
孙东杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the treatment of allergic dermatitis, topical antiallergic drugs are one of the main treatments, including: glucocorticoids, although they can resist allergies and relieve itching to a certain extent, but long-term topical use has adverse effects such as local skin atrophy, infection, and abnormal pigmentation. In addition, there are other non-glucocorticoid drugs, such as calcineurin inhibitors and various traditional Chinese medicine monomers or compound ingredients, although they have certain effects , there are more or less defects such as weak curative effect, high price and local stimulation
Overall, anti-allergic dermatitis topical drugs are not effective for a considerable number of patients with atopic dermatitis

Method used

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  • Application of limonene in preparation of anti-allergic dermatitis drug
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  • Application of limonene in preparation of anti-allergic dermatitis drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The application of limonene in the preparation of anti-allergic dermatitis drugs, the following detailed analysis of limonene on the impact of atopic dermatitis through animal experiments.

[0015] 1. Experimental group:

[0016] ① Normal control group

[0017] ②Model group

[0018] ③Limonene low dose group (100mg / kg / d)

[0019] ④Limonene medium dose group (200mg / kg / d)

[0020] ⑤Limonene high dose group (400mg / kg / d)

[0021] ⑥Positive drug dexamethasone group (0.41mg / kg / d)

[0022] 2. Modeling

[0023] Above-mentioned 6 experimental groups, every group of 12 SD rats, male, 180-220g, except the normal control group, the remaining animals were smeared with 7% DNCB (dinitrate) on both sides of the abdomen (2cm * 2cm) and the right ear, respectively. After 24 hours, apply 1% 50 μL DNCB acetone solution again to strengthen the stimulation, and then apply 50 μL 1% DNCB acetone solution every 5 days for sensitization, a total of 3 times.

[0024] 3. Intervention and eva...

Embodiment 2

[0039] Effects of limonene on passive cutaneous anaphylaxis (PCA) and mast cell degranulation

[0040] 1. Experimental grouping

[0041] ①, normal control group

[0042] ②, model group

[0043] ③. Limonene low dose group (100mg / kg / d)

[0044] ④, limonene medium dose group (200mg / kg / d)

[0045] ⑤. Limonene high dose group (400mg / kg / d)

[0046] ⑥. Positive drug dexamethasone group (0.41mg / kg / d)

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PUM

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Abstract

The invention discloses application of limonene in preparation of an anti-allergic dermatitis drug, and belongs to the technical field of biological medicines. The limonene can inhibit DNCB acetone solution induced contact dermatitis, and has the effects of inhibiting passive skin allergic reaction and mast cell degranulation; therefore, the limonene can be used for treating allergic dermatitis caused by various reasons, and has a better treatment effect.

Description

technical field [0001] The invention relates to the application of limonene in the preparation of anti-allergic dermatitis drugs, and belongs to the technical field of biomedicine. Background technique [0002] Limonene, also known as limonene, is a monoterpene compound, a colorless oily liquid with a lemon-like fragrance. It has good antitussive, expectorant and antibacterial effects. Its dextrorotatory body is commonly used and can be used as a raw material for preparing artificial orange blossom, sweet flower, lemon, and bergamot oil. It can also be used as a fresh top fragrance for cosmetics, soaps and daily chemical essences, in the cologne type, jasmine type in floral fragrance, lavender type, and pine, aldehyde, woody, fruity or fragrance type Both are suitable. As a modifier in food flavors, it is used in formulas such as white lemon, fruity and spicy. [0003] Allergic dermatitis is a large class of diseases with common features of itching and rash, mainly inclu...

Claims

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Application Information

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IPC IPC(8): A61K31/015A61P37/08A61P17/00A61P17/04
CPCA61K31/015A61P17/00A61P17/04A61P37/08
Inventor 孙东杰
Owner 孙东杰
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