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A resveratrol particle and its preparation method

A technology of resveratrol and granules, applied in the field of medicine, can solve the problems such as the loss of biological activity of resveratrol, and achieve the effects of improving antioxidant capacity, protecting structural integrity and stability, and simple operation.

Active Publication Date: 2022-08-09
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method uses a laboratory-level microfluidic spraying process to prepare resveratrol particles with uniform size, uniform performance and regular shape, and has the advantages of high release and strong antioxidant capacity, and at the same time solves the problem of resveratrol The technical problem of losing biological activity due to the interference of light, heat, oxygen and other factors

Method used

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  • A resveratrol particle and its preparation method
  • A resveratrol particle and its preparation method
  • A resveratrol particle and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Weigh 9.9g of hydroxypropyl-β-cyclodextrin and dissolve it in 90g of deionized water to prepare a precursor solution;

[0043] Weigh 0.1 g of resveratrol and dissolve it in the above-mentioned hydroxypropyl-β-cyclodextrin aqueous solution to prepare a precursor solution with a total solid content of 10wt%;

[0044]Pour the prepared precursor liquid into the material tank, connect it to the microfluidic atomizer through a conduit, open the valve of the gas cylinder, atomize the precursor liquid into uniform droplets and inject it into the spray drying tower to prepare a uniform particle size. The corresponding laboratory-level microfluidic spray drying tower process parameters are set to the inlet temperature of 180 °C, the outlet temperature of 80 °C, the feed pressure of 0.3Pa, the hot air flow rate of 250L / min, and the dispersion air flow rate of 5L / min. The piezoelectric ceramic vibration frequency in the atomizer is 10000HZ, and the amplitude is 15Vpp.

[0045] Acc...

Embodiment 2

[0053] Weigh 30.8g of hydroxypropyl-β-cyclodextrin and dissolve it in deionized water to prepare a 0.2M aqueous solution of hydroxypropyl-β-cyclodextrin;

[0054] Weigh 3.7g of resveratrol and dissolve it in the above-mentioned hydroxypropyl-β-cyclodextrin aqueous solution;

[0055] The above aqueous solution was placed in a shaker at a speed of 150 rpm at 25 °C for 72 h in the dark to be shaken to form a precursor solution 1;

[0056] Weigh 0.2g of chitosan and dissolve it in the above-mentioned precursor solution 1 to configure as precursor solution 2;

[0057] Pour the configured precursor liquid 1 and precursor liquid 2 into two material tanks respectively, connect them to the microfluidic atomizer through the conduit, open the valve of the gas cylinder, atomize the precursor liquid into uniform droplets and inject them into the spray drying tower. Particles with uniform particle size are prepared in the cylinder, and the particle morphology is as follows figure 2 shown....

Embodiment 3

[0062] Weigh 30.8g of hydroxypropyl-β-cyclodextrin and dissolve it in deionized water to prepare a 0.2M aqueous solution of hydroxypropyl-β-cyclodextrin;

[0063] Weigh 3.7g of resveratrol and dissolve it in the above-mentioned hydroxypropyl-β-cyclodextrin aqueous solution;

[0064] The above aqueous solution was placed in a shaker at a speed of 150 rpm at 25 °C for 72 h in the dark to be shaken to form a precursor solution 1;

[0065] Weigh 0.2g of chitosan and dissolve it in the above-mentioned precursor solution 1 to configure as precursor solution 2;

[0066] Pour the configured precursor liquid 1 and precursor liquid 2 into two material tanks respectively, connect them to the microfluidic atomizer through a conduit, open the valve of the gas cylinder, atomize the precursor liquid into uniform droplets and inject them into spray freeze drying. Particles with uniform particle size are prepared in the tower, and the particle morphology is as follows Figure 5 shown. The c...

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Abstract

The invention relates to the field of medicine, in particular to a resveratrol granule and a preparation method thereof. The preparation method comprises: dissolving a carrier in water to obtain an aqueous carrier solution; the carrier is one of hydroxypropyl-β-cyclodextrin, hydroxypropyl-γ-cyclodextrin, chitosan or whey protein isolate or several kinds; dissolving resveratrol in the carrier aqueous solution, shaking to make a precursor solution; filtering the precursor solution, and preparing resveratrol particles by a microfluidic spray process, the microfluidic spray process is microfluidic spray drying technology or microfluidic spray freeze drying technology. The invention adopts a laboratory-level microfluidic spray process to prepare resveratrol particles with uniform size, uniform performance and regular morphology, and has the advantages of high release amount and strong antioxidant capacity, and simultaneously solves the problem that resveratrol easily The technical problem of losing biological activity due to the interference of light, heat, oxygen and other factors.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a resveratrol granule and a preparation method thereof. Background technique [0002] The polyphenol resveratrol is a natural compound found in different types of fruits, vegetables and red wine. This polyphenolic compound exists as two isomers of cis and trans resveratrol, with the trans isomer being more active than the cis isomer. [0003] Resveratrol has attracted widespread attention from researchers for its therapeutic effects on various diseases, such as cardiovascular disease, diabetes, neurodegenerative diseases, lung inflammation, and cancer. In vitro and in vivo studies indicate that the beneficial properties of resveratrol are related to its anti-inflammatory and antioxidant capacity, which can protect cells from oxidative damage. However, due to the fact that the active substance of resveratrol is prone to configuration transformation under light and high temperature condit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/05A61K47/40A61K47/36A61K47/42A61P9/00A61P3/10A61P25/28A61P11/00A61P29/00A61P35/00A61P39/06
CPCA61K9/1652A61K9/1658A61K31/05A61P9/00A61P3/10A61P25/28A61P11/00A61P29/00A61P35/00A61P39/06
Inventor 吴铎狄爱俊张盛宇刘旋
Owner SUZHOU UNIV
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