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Resveratrol particle and preparation method thereof

A technology of resveratrol and granules, which is applied in the field of medicine, can solve the problems of resveratrol losing biological activity, achieve the effects of improving antioxidant capacity, protecting structural integrity and stability, and simple operation

Active Publication Date: 2020-09-11
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method uses a laboratory-level microfluidic spraying process to prepare resveratrol particles with uniform size, uniform performance and regular shape, and has the advantages of high release and strong antioxidant capacity, and at the same time solves the problem of resveratrol The technical problem of losing biological activity due to the interference of light, heat, oxygen and other factors

Method used

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  • Resveratrol particle and preparation method thereof
  • Resveratrol particle and preparation method thereof
  • Resveratrol particle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Weigh 9.9g of hydroxypropyl-β-cyclodextrin and dissolve it in 90g of deionized water to make a precursor solution;

[0043] Weighing 0.1 g of resveratrol and dissolving it in the aqueous solution of hydroxypropyl-β-cyclodextrin to prepare a precursor solution with a total solid content of 10 wt %;

[0044]Pour the ready-to-use precursor liquid into the material tank, connect it to the microfluidic atomizer through the catheter, open the valve of the gas cylinder, atomize the precursor liquid into uniform droplets, and inject it into the spray drying tower to prepare uniform particle size The corresponding laboratory-level microfluidic spray drying tower process parameters are set as inlet temperature 180°C, outlet temperature 80°C, feed pressure 0.3Pa, hot air flow rate 250L / min, dispersion air flow rate 5L / min, The vibration frequency of the piezoelectric ceramic in the atomizer is 10000HZ, and the amplitude is 15Vpp.

[0045] According to the above-mentioned preparat...

Embodiment 2

[0053] Weigh 30.8g of hydroxypropyl-β-cyclodextrin and dissolve it in deionized water to make a 0.2M aqueous solution of hydroxypropyl-β-cyclodextrin;

[0054] Weigh 3.7g resveratrol and dissolve in the above-mentioned hydroxypropyl-β-cyclodextrin aqueous solution;

[0055] Place the above aqueous solution in a shaker at a speed of 150rpm at 25°C in the dark for 72 hours to prepare the precursor solution 1;

[0056] Weigh 0.2g chitosan and dissolve it in the above precursor solution 1 to configure it as precursor solution 2;

[0057] Pour the configured precursor solution 1 and precursor solution 2 into two material tanks respectively, connect them to the microfluidic atomizer through a catheter, open the valve of the gas cylinder, atomize the precursor solution into uniform droplets and inject them into the spray drying tower The particles with uniform particle size are prepared in the cylinder, and the particle shape is as follows: figure 2 shown. The process parameters o...

Embodiment 3

[0062] Weigh 30.8g of hydroxypropyl-β-cyclodextrin and dissolve it in deionized water to make a 0.2M aqueous solution of hydroxypropyl-β-cyclodextrin;

[0063] Weigh 3.7g resveratrol and dissolve in the above-mentioned hydroxypropyl-β-cyclodextrin aqueous solution;

[0064] Place the above aqueous solution in a shaker at a speed of 150rpm at 25°C in the dark for 72 hours to prepare the precursor solution 1;

[0065] Weigh 0.2g chitosan and dissolve it in the above precursor solution 1 to configure it as precursor solution 2;

[0066] Pour the configured precursor solution 1 and precursor solution 2 into two material tanks respectively, connect them to the microfluidic nebulizer through a catheter, open the valve of the gas cylinder, atomize the precursor solution into uniform droplets, and inject it into spray freeze-drying The particles with uniform particle size are prepared in the tower tube, and the particle shape is as follows: Figure 5 shown. The process parameters o...

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Abstract

The invention relates to the field of medicines, in particular to a resveratrol particle and a preparation method thereof. The preparation method comprises the following steps: dissolving a carrier inwater to obtain a carrier aqueous solution, wherein the carrier is one or more of hydroxypropyl-beta-cyclodextrin, hydroxypropyl-gamma-cyclodextrin, chitosan or isolated whey protein; dissolving resveratrol in the carrier aqueous solution, and oscillating to prepare a precursor solution; and filtering the precursor solution, and preparing the resveratrol particle by adopting a microfluidic sprayprocess, wherein the microfluidic spray process is a microfluidic spray drying technology or a microfluidic spray freeze drying technology. The resveratrol particle with uniform size, uniform performance and regular morphology is prepared by adopting a laboratory-grade microfluidic spray process, and has the advantages of high release amount and strong oxidation resistance, and meanwhile, the technical problem that the resveratrol is easily interfered by factors such as light, heat and oxygen to lose bioactivity is solved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a resveratrol granule and a preparation method thereof. Background technique [0002] The polyphenol resveratrol is a natural compound found in different types of fruits, vegetables and red wine. This polyphenolic compound exists as two isomers of resveratrol, cis and trans, with the trans isomer being more active than the cis. [0003] Resveratrol has attracted extensive attention from researchers for its therapeutic effects on various diseases, such as cardiovascular disease, diabetes, neurodegenerative diseases, lung inflammation, and cancer, among others. In vitro and in vivo studies point to the beneficial properties of resveratrol related to its anti-inflammatory and antioxidant capacity, which can protect cells from oxidative damage. However, since the resveratrol active substance is prone to conformational transformation under light and high temperature conditions, the more acti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/05A61K47/40A61K47/36A61K47/42A61P9/00A61P3/10A61P25/28A61P11/00A61P29/00A61P35/00A61P39/06
CPCA61K9/1652A61K9/1658A61K31/05A61P9/00A61P3/10A61P25/28A61P11/00A61P29/00A61P35/00A61P39/06
Inventor 吴铎狄爱俊张盛宇刘旋
Owner SUZHOU UNIV
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