Application of Gensci073 or analogues thereof

A technology of analogues and drugs, applied in the field of medicine, can solve problems such as lack of related diseases

A technology of analogues and drugs, applied in the field of medicine, can solve problems such as lack of related diseases

CN111643501APending Publication Date: 2020-09-11CHANGCHUN GENESCIENCE PHARM CO LTD
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  • Application of Gensci073 or analogues thereof
  • Application of Gensci073 or analogues thereof
  • Application of Gensci073 or analogues thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0033] 1. Test substance:

[0034] 1.1 Test drug: Gensci073, from Changchun Jinsai Pharmaceutical Co., Ltd., white powder, room temperature, sealed.

[0035] 1.2 Positive control drug: name: domperidone, from Xi'an Janssen Pharmaceutical Co., Ltd., specification: 10mg / tablet; batch number: 181107417; storage condition: room temperature.

[0036] 2. Experimental animals

[0037] Animals: SPF grade Wistar rats, male, 6-8 weeks old, 180-220 g, 60 rats. Source: Shanghai Slack Experimental Animal Co., Ltd., animal certificate number: 20170005019607, animal production license number: SCXK (Shanghai) 2017-0005. Breeding environment: The environment of the animal room is maintained at a temperature of 23±2°C, a humidity of 40% to 70%, and alternating light and dark for 12 hours. Animals were kept 5 per cage, and the litter (corn cob litter, Suzhou Daichuan Trading Co., Ltd.) was replaced twice a week. Food and drinking water: The experimental rats were fed with SPF rat growth and ...

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Abstract

The invention relates to the technical field of medicines, in particular to application of Gensci073 or analogues thereof. The invention provides the application of Gensci073 or analogues thereof, andparticularly provides application of Gensci073 in preparation of medicines for improving food intake, promoting gastrointestinal motility and treating functional dyspepsia. Researches show that Gensci073 can obviously improve the gastric emptying rate and small intestine propulsion rate of a model rat, and the gastric emptying rate of an animal is reduced along with the increase of the administration dosage of Gensci073 and the small intestine propulsion rate of the animal is increased along with the increase of the administration dosage of Gensci073 within a measured range.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular to the application of Gensci073 or its analogs. Background technique [0002] Functional dyspepsia (funcfiolmldyspepsia, FD) is characterized by recurrent postprandial fullness, early satiety, anorexia, belching, nausea, vomiting, epigastric pain, epigastric burning sensation or acid regurgitation, and is excluded by various examinations. A common clinical syndrome of organic, systemic, or metabolic disease. [0003] The incidence of FD in my country is increasing year by year. Adult patients with indigestion as the main complaint account for about 11% of general internal medicine outpatients and 53% of digestive specialist outpatients. There is no standardized statistics on the incidence of FD in pediatric patients in my country, but it has become a common reason for seeing a doctor in pediatric gastroenterology clinics. Because many pediatric clinicians lack sufficient ...

Claims

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Application Information

Patent Timeline
11 Sep 2020
Publication
CN111643501A
IPC
A61K31/454; A61P1/14; A61P1/00; A61P1/08; A61P1/06; A61P1/04
CPC
A61K31/454; A61P1/00; A61P1/04; A61P1/06; A61P1/08; A61P1/14
Inventors
金磊; 王思勤