High-strength anti-swelling chitosan-based physical hydrogel and preparation method thereof

A chitosan and anti-swelling technology, applied in the field of semi-interpenetrating network hydrogel, can solve the problems of original performance damage and limited practicality, and achieve excellent mechanical properties, good biocompatibility, excellent mechanical properties and Effect of anti-swelling properties

Inactive Publication Date: 2020-09-11
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a common property of hydrogels, water absorption will cause ordinary hydrogels to "swell" under liquid or physiological conditions; especially acrylamide hydrogels, once used in a high-water environment, their original properties will be reduced. Can be damaged to a great extent, severely limiting its utility, especially in the fields of medical dressings, implant materials, etc.

Method used

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  • High-strength anti-swelling chitosan-based physical hydrogel and preparation method thereof
  • High-strength anti-swelling chitosan-based physical hydrogel and preparation method thereof
  • High-strength anti-swelling chitosan-based physical hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1) Weigh 4g of chitosan with a viscosity-average molecular weight of 20w and a deacetylation degree of 90%, and disperse it in 200mL of deionized water, add 5.84mL (85.2mmol) of acrylic acid, stir and dissolve, and react at 60°C for 16h. After the reaction, adjust the pH of the product to 10-12 with sodium hydroxide solution, then dialyze with a dialysis bag for 5 days, and freeze-dry to obtain CEC;

[0026] 2) Add 4g SDS and 5.265g NaCl to 100mL deionized water to prepare solution A;

[0027] 3) Take 5mL of the above solution A, add 0.025g of CEC into it, stir evenly to obtain a uniform and transparent solution, then add 1g of AM and 109μL of SMA in turn, stir and dissolve to obtain solution B;

[0028] 4) Add 50 μL of APS solution (0.1g / mL) to the above solution B, stir evenly to obtain a pre-polymerized solution, quickly inject it into the mold, and ultrasonically remove air bubbles;

[0029] 5) Place the mold filled with the pre-polymerization solution at 60°C for ...

Embodiment 2

[0033] 1) Weigh 4g of chitosan with a viscosity-average molecular weight of 20w and a deacetylation degree of 90%, and disperse it in 200mL of deionized water, add 5.84mL (85.2mmol) of acrylic acid, stir and dissolve, and react at 60°C for 16h. After the reaction, adjust the pH of the product to 10-12 with sodium hydroxide solution, then dialyze with a dialysis bag for 5 days, and freeze-dry to obtain CEC;

[0034] 2) Add 4g SDS and 5.625g NaCl to 100mL deionized water to prepare solution A;

[0035] 3) Take 5mL of the above solution A, add 0.05g of CEC to it, stir evenly to obtain a uniform and transparent solution, then add 1g of AM and 109μL of SMA in turn, fully stir and dissolve to obtain solution B;

[0036]4) Add 50 μL of APS solution (0.1g / mL) to the above solution B, stir evenly to obtain a pre-polymerized solution, quickly inject it into the mold, and ultrasonically remove air bubbles;

[0037] 5) Place the mold filled with the pre-polymerization solution at 60°C fo...

Embodiment 3

[0040] 1) Weigh 4g of chitosan with a viscosity average molecular weight of 20w and a deacetylation degree of 90%, and disperse it in 200mL of deionized water, add 5.84mL (85.2mmol) of acrylic acid, stir and dissolve, and react at 60°C for 16h. After the reaction, adjust the pH of the product to 10-12 with sodium hydroxide solution, then dialyze with a dialysis bag for 5 days, and freeze-dry to obtain CEC;

[0041] 2) Add 4g SDS and 5.625g NaCl to 100mL deionized water to prepare solution A;

[0042] 3) Take 5mL of the above solution A, add 0.075g of CEC into it, stir evenly to obtain a homogeneous and transparent solution, then add 1g of AM and 109μL of SMA in turn, stir well and dissolve to obtain solution B;

[0043] 4) Add 50 μL of APS solution (0.1g / mL) to the above solution B, stir evenly to obtain a pre-polymerized solution, quickly inject it into the mold, and ultrasonically remove air bubbles;

[0044] 5) Place the mold filled with the pre-polymerization solution at ...

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Abstract

The invention discloses a high-strength anti-swelling chitosan-based physical hydrogel and a preparation method thereof. The physical hydrogel is prepared by introducing CEC with low carboxylation degree into a polyacrylamide hydrophobic cross-linking system (HPAM) by adopting a semi-interpenetrating network strategy and utilizing electrostatic interaction, crystallization effect and the like of N-carboxyethyl chitosan (CEC). The preparation method mainly comprises the following steps: sequentially adding CEC, acrylamide and octadecyl methacrylate into a mixed solution of lauryl sodium sulfateand sodium chloride, stirring the components until complete dissolution, adding an ammonium persulfate initiator, performing ultrasonic treatment for removing bubbles, and carrying out a reaction inan oven at 40-80 DEG C for at least 6 hours, thereby finally obtaining the transparent HPAM-CEC physical hydrogel. The prepared physical hydrogel has excellent mechanical properties and swelling resistance, and has biocompatibility, self-repairing performance and conductivity, the application range of the chitosan-based hydrogel material is further widened, and the chitosan-based hydrogel materialis expected to be applied to the fields of wearable flexible electronic devices and soft robots.

Description

technical field [0001] The invention relates to a semi-interpenetrating network hydrogel, in particular to a high-strength anti-swelling chitosan-based physical hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a three-dimensional network material composed of macromolecules, which is widely used in various fields such as life and industry because of its excellent performance. As a common property of hydrogels, water absorption will cause ordinary hydrogels to "swell" under liquid or physiological conditions; especially acrylamide hydrogels, once used in a high water content environment, their original properties will be reduced. It will be damaged to a great extent, which seriously limits its practicality, especially in the fields of medical dressings and implant materials. The physical interaction (such as electrostatic interaction, hydrogen bond, microcrystalline structure, etc.) is the key to constructing physical hydrogels, which can b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F220/18C08F220/56
CPCC08F251/00C08F220/1818C08F220/56
Inventor 王征科傅倍佳
Owner ZHEJIANG UNIV
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