Ultrasonic surface standing wave microfluidic chip for micro-particle separation and application

A microfluidic chip and microparticle technology, applied in the field of microfluidic analysis, can solve the problems of low particle separation efficiency, waste of time and cost, and achieve the effect of reducing difficulty, improving separation efficiency and separation purity

Active Publication Date: 2020-09-15
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] Aiming at the problems existing in the prior art that the particle separation efficiency of the microfluidic chip is not high and wastes a lot of time and cost, the parameter design of the ultrasonic surface standing wave action area is only based on empirical judgment, and a lot of time and cost are wasted. Ultrasonic surface standing wave microfluidic chip for microparticle separation and its application, use theoretical analysis to determine the preparation parameters of the microfluidic chip, and improve the separation efficiency of the microfluidic chip in particle separation

Method used

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Embodiment 1

[0035] This embodiment specifically describes an ultrasonic surface standing wave microfluidic chip, including a piezoelectric substrate, an interdigital transducer, a microfluidic cavity, and a drive circuit. The interdigital transducer is attached to the piezoelectric substrate, and the interdigital transducer The device emits ultrasonic surface waves, forms standing field waves on the surface of the substrate, and exerts ultrasonic radiation force on the fluid particles in the microfluidic cavity; the microfluidic cavity is bonded or bonded to the piezoelectric substrate, and the cross section of the internal channel of the microfluidic cavity is rectangular; The driving circuit drives the interdigital transducer to work. Particles enter the microfluidic cavity of the microfluidic chip using the sheath flow technology known in the art. Under the action of ultrasonic surface standing waves, different types of particles present different flow trajectories, and finally enter di...

Embodiment 2

[0059] This embodiment is basically the same as Example 1, the difference is that this embodiment separates polystyrene (Polystyrene, PS) microspheres with a radius of 3 μm and 3.8 μm, requiring separation purity d>0.95, particle flux P =100 pieces / second, and the microfluidic chip in this embodiment is a PM-SSAW chip.

[0060] According to the parameters of the particles to be separated, calculate the cavity size of the microfluidic cavity of the chip, the flow rate of the particle fluid, and the width of the ultrasonic action area, and make a chip and perform particle separation. Specific steps are as follows:

[0061] First determine the structural composition of the chip and its separation parameters for the two types of microparticles:

[0062] A 128°Y tangential lithium niobate crystal sheet with a thickness of 0.5mm was selected to prepare the piezoelectric substrate of the microfluidic chip, and PDMS was selected as the material for the channel wall of the microfluidi...

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Abstract

The invention discloses an ultrasonic surface standing wave microfluidic chip for micro-particle separation and application, belongs to the technical field of microfluidic analysis, and aims at the problems in the prior art that when a microfluidic chip is used for separating micro-particles, parameter design of the ultrasonic surface standing wave action area is judged only according to experience, particle separation efficiency is low and a large amount of time and cost are wasted. The invention provides a method for separating micro-particles based on an ultrasonic surface standing wave microfluidic chip. The method comprises the steps: determining the size of the sectional area of an internal channel of a microfluidic cavity of the microfluidic chip, the length of an ultrasonic standing wave action area, the inclination angle of the interdigital transducer, the phase change rate of the interdigital transducer, the aperture size of the interdigital transducer, the liquid flow rate during working and the input voltage, and carrying out particle separation. During micro-particle separation, chip design mainly relates to an ultrasonic surface standing wave action area, other areasand focusing methods are not limited, particle separation operation steps and device preparation difficulty are reduced, and particle separation efficiency is improved.

Description

technical field [0001] The invention relates to the technical field of microfluidic analysis, more specifically, to an ultrasonic surface standing wave microfluidic chip for particle separation and its application. Background technique [0002] In recent years, ultrasonic microfluidics has attracted widespread attention due to its characteristics of no contact, no label and good biocompatibility. Ultrasonic microfluidic chips can be used to manipulate, focus, arrange and separate microparticles or cells. Ultrasonic microfluidic chips can be divided into two types based on ultrasonic body waves and based on ultrasonic surface waves. Unlike the bulk wave-based method, the ultrasonic surface wave-based method does not depend on the resonance generated by the channel wall, and has a flexible design space and strong application potential. Among surface wave chips, standing wave chips have a higher acoustic energy density and are widely used. [0003] An important application o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/50273B01L3/502761B01L2200/0652B01L2400/0415B01L2400/0439
Inventor 郭霞生刘子星章东
Owner NANJING UNIV
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