Uses of flavonoids of marine fungal origin

A technology of flavonoids and marine fungi, applied in the field of medical applications, to achieve the effects of protecting oxidative stress, reducing the expression of ROS, and protecting against
CN111728964BActive Publication Date: 2022-02-25UNIV OF JINAN
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
UNIV OF JINAN
Publication Date
2022-02-25

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Abstract

The invention discloses the use of flavonoids derived from marine fungi. The general formula of the flavonoids is specifically 2, 3, 4, 6, 8-pentahydroxy-1-methylflavone and benzo-γ-pyrone The use of flavonoids extracted from two marine microorganisms as Nrf2 activators in the treatment of cardiovascular and cerebrovascular diseases. The flavonoids in the present invention are extracted from the metabolites of deep-sea fungi. Through the research of the present invention, it is found that 2, 3, 4, 6, 8-pentahydroxy-1-methyl flavone and benzo-γ-pyran By activating Nrf2, ketones can reduce the expression of intracellular reactive oxygen species ROS, protect endothelial cells from oxidative stress and damage, and play a role in antioxidant protection of endothelial cells. The invention provides support for studying 2, 3, 4, 6, 8-pentahydroxy-1-methylflavone and benzo-γ-pyrone as Nrf2 activators for treating cardiovascular and cerebrovascular diseases.
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Description

technical field

[0001] The present invention relates to the technical field of medical application, relates to the use of flavonoids derived from marine fungi, and in particular to the use of 2,3,4,6,8-pentahydroxy-1-methylflavone and benzo-γ-pyrone . Background technique

[0002] The transcription factor Nrf2 belongs to CNC-Bzip (capncollar subfamily of basic leucine-zipper), which is the family of CNC leucine zipper transcription activators. central regulator. By inducing and regulating the constitutive and inducible expression of a series of antioxidant proteins, Nrf2 can reduce the cell damage caused by reactive oxygen species and electrophiles, keep the cells in a stable state, and maintain the body's redox dynamic balance. important access. A large number of studies have shown that Nrf2 is related to the occurrence of various diseases.

[0003] Flavonoids (flavonoids) are a class of compounds that exist in nature and have a 2-phenylchromone (flavone) structure. Th...

Claims

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