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Carrier with active oxygen response, preparation method thereof and composite material

A composite material, active oxygen technology, applied in the direction of organic active ingredients, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. application and other issues, to achieve the effect of good medical prospects, low cost, and high efficiency of ROS

Pending Publication Date: 2021-12-21
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the applications of these phytochemicals are limited due to their low solubility, low bioavailability, instability, and in vitro and in vivo degradability

Method used

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  • Carrier with active oxygen response, preparation method thereof and composite material
  • Carrier with active oxygen response, preparation method thereof and composite material
  • Carrier with active oxygen response, preparation method thereof and composite material

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preparation example Construction

[0042] The second aspect of the embodiment of the present application provides a method for preparing the above carrier, including the following steps:

[0043] S01: Provide mesoporous silica nanoparticles;

[0044] S02: mixing the mesoporous silica nanoparticles with the above-mentioned fluorescein to avoid light for labeling reaction to obtain fluorescein-labeled mesoporous silica nanoparticles;

[0045] S03: Mix the fluorescein-labeled mesoporous silica nanoparticles with the above-mentioned silane phenylene sulfide molecules to carry out a catalytic reaction to obtain a carrier.

[0046] The preparation method of the active oxygen-responsive carrier provided by this application is obtained by labeling mesoporous silica nanoparticles with fluorescein and silane phenylene sulfide molecules in sequence, so that the carrier is in the mesoporous silica nanoparticles Based on the combination of fluorescein and silane phenylene sulfide molecules, the preparation method has simpl...

Embodiment 1

[0058] Example 1 Carrier Construction with Active Oxygen Response

[0059] 1. Synthesis of Benzenethiol-3-Isocyanatopropyltriethoxysilane (PhSAPTES);

[0060] With 2mmol of (phenylthio) acetic acid [(Phenylthio) acetic acid], 2.2mmol of 11-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) and 2mmol of N -Hydroxysuccinimide (NHS) was dissolved in 20ml of chloroform by means of ultrasonic assistance; then 2.46mmol of 3-aminopropyltriethoxysilane (APTES) (800μL) was added to the reaction system, and in React at room temperature for 24 hours. After the reaction, the obtained clear light yellow solution was concentrated to 4ml and separated by silica gel column chromatography, the mobile phase was petroleum ether: ethyl acetate = 3:2, and finally the solvent was removed by rotary evaporation to obtain a light yellow liquid The final product, namely silane phenylene sulfide with the following chemical structure, has a yield of about 68%.

[0061]

[0062] 2. Syn...

Embodiment 2

[0075] Carrying band and release of embodiment 2 procyanidins (PC)

[0076] 1. Carrier tape of procyanidin (PC)

[0077] Take 6mL of ultrapure water in a 15mL small centrifuge tube, add 4mL of methanol, and mix evenly; weigh 15mg of procyanidin (PC) in a 15mL small centrifuge tube, add 6mL of methanol-water mixed solution for ultrasonic dissolution; take 50mg of Example 1 The prepared carrier (fmMSNs-phs) was placed in a 15mL small centrifuge tube, and the supernatant was discarded by centrifugation. The obtained particles were washed once with ultrapure water, and the supernatant was discarded by centrifugation; 6 mL of 2.5 mg / mL PC was added to the obtained particles methanol aqueous solution, ultrasonically dissolved and then sonicated for 2min; the mixed solution was rotated and mixed on a rotary mixer for 24h, sealed and protected from light; after mixing, the resulting solution was centrifuged, and the supernatant and particles were separated to obtain the composite mate...

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Abstract

The invention relates to the technical field of drug carriers, in particular to a carrier with active oxygen response, a preparation method of the carrier and a composite material. The carrier with active oxygen response comprises mesoporous silica nanoparticles, fluorescein combined with the mesoporous silica nanoparticles, and silane phenyl sulfide molecules. The silane phenyl sulfide molecule has good active oxygen response, and fluorescein can monitor the active oxygen response effect in real time. Therefore, when the carrier is used for loading polyphenol medicines, the polyphenol medicines can be intelligently released in a relatively high-concentration ROS environment, so that safety and stability are achieved, and the bioavailability of polyphenol substances is improved.

Description

technical field [0001] The application belongs to the technical field of drug carriers, and in particular relates to a carrier capable of responding to active oxygen, a preparation method and a composite material thereof. Background technique [0002] Mesoporous silica nanoparticles (MSNs) due to their large specific surface area, high pore volume, uniform and adjustable pore size, easy chemical modification of internal and external surfaces, excellent thermal / chemical stability and good With advantages such as biological safety, it is widely used in research fields such as drug loading, bioimaging, biosensing, and synergistic treatment of cancer. [0003] Reactive oxygen species (reactive oxygen species, ROS) is a kind of one-electron reduction product of oxygen in the body, including superoxide anion (O 2 - ), the two-electron reduction product hydrogen peroxide (H 2 o 2 ), three-electron reduction products hydroxyl radicals (OH) and nitric oxide, etc.; play a key role...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K47/24A61K9/52A61K31/353A61P39/06A61K49/00
CPCA61K47/02A61K47/24A61K9/5115A61K9/5123A61K9/5192A61K31/353A61P39/06A61K49/0019A61K49/005A61K49/0052A61K49/0093
Inventor 王林吴紫媚蒋星竹王露露侯峤丹王子杰
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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