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A kind of nano-enzyme bactericide based on double metal organic framework and its preparation method and application

An organic framework and bimetallic technology, applied in the field of nanozyme bactericide and its preparation, can solve the problems of inability to achieve sterilization effect, poor catalytic effect, low stability, etc., achieve inhibition of bacterial growth, low cost, and simple preparation method Effect

Active Publication Date: 2021-11-19
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the structure of conventional MOFs materials is relatively loose, accompanied by the release of metal ions in aqueous solution, it still has the disadvantages of low stability and poor catalytic effect, and cannot achieve effective sterilization effect.

Method used

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  • A kind of nano-enzyme bactericide based on double metal organic framework and its preparation method and application
  • A kind of nano-enzyme bactericide based on double metal organic framework and its preparation method and application

Examples

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Effect test

Embodiment 1

[0041] The application of a nano-enzyme fungicide based on a bimetallic organic framework in inhibiting food-borne pathogens, the steps are as follows:

[0042] (1) Dissolve 0.5 mmol of cerium nitrate, 0.5 mmol of copper nitrate and 1 mmol of pyromellitic acid into 25 mL of ethanol at the same time, mix well and place the solution on a magnetic stirrer (rotating speed 1200 rpm), and mix and react at room temperature for 2.5 h After the reaction, the product was obtained by centrifugation, washed with ethanol for 5 times, and then vacuum-dried at 60 °C for 12 h to obtain a bimetallic organic framework;

[0043] (2) The bimetallic organic framework described in step (1) was placed in a tube furnace (temperature 300°C), and then calcined in an air atmosphere for 2.5 hours to obtain a nanozyme fungicide, which was stored in a sealed container at room temperature ;

[0044](3) Take a small amount of strains of Escherichia coli (ATCC700728) and streak on the LB solid medium, then p...

Embodiment 2

[0049] The application of a nano-enzyme fungicide based on a bimetallic organic framework in inhibiting food-borne pathogens, the steps are as follows:

[0050] (1) Dissolve 0.5 mmol of cerium nitrate, 0.5 mmol of copper nitrate and 1 mmol of pyromellitic acid into 25 mL of ethanol at the same time, mix well and place the solution on a magnetic stirrer (rotating speed 1200 rpm), and mix and react at room temperature for 2.5 h After the reaction, the product was obtained by centrifugation, washed with ethanol for 5 times, and then vacuum-dried at 60 °C for 12 h to obtain a bimetallic organic framework;

[0051] (2) The bimetallic organic framework described in step (1) was placed in a tube furnace (temperature 300°C), and then calcined in an air atmosphere for 2.5 hours to obtain a nanozyme fungicide, which was stored in a sealed container at room temperature ;

[0052] (3) Take a small amount of Staphylococcus aureus (ATCC6538) strain and streak it on the LB solid medium, the...

Embodiment 3

[0057] The application of a nano-enzyme fungicide based on a bimetallic organic framework in inhibiting food-borne pathogens, the steps are as follows:

[0058] (1) Dissolve 0.5 mmol of cerium nitrate, 0.5 mmol of copper nitrate and 1 mmol of pyromellitic acid into 25 mL of ethanol at the same time, mix well and place the solution on a magnetic stirrer (rotating speed 1200 rpm), and mix and react at room temperature for 2.5 h After the reaction, the product was obtained by centrifugation, washed with ethanol for 5 times, and then vacuum-dried at 60 °C for 12 h to obtain a bimetallic organic framework;

[0059] (2) The bimetallic organic framework described in step (1) was placed in a tube furnace (temperature 300°C), and then calcined in an air atmosphere for 2.5 hours to obtain a nanozyme fungicide, which was stored in a sealed container at room temperature ;

[0060] (3) Take a small amount of Salmonella (ATCC14028) strain and streak it on the LB solid medium, then place th...

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Abstract

The invention discloses a nano-enzyme bactericide based on a bimetallic organic framework, a preparation method and an application thereof. The preparation method is: (1) using a solution as a reaction medium, reacting cerium nitrate, copper nitrate and pyromellitic acid at room temperature to obtain a bimetallic organic framework; (2) preparing the bimetallic organic framework in an air atmosphere, 200- Calcining at 400° C. for 1.5 to 3.5 hours to obtain a bimetallic organic framework-based nanozyme fungicide for inhibiting food-borne pathogenic bacteria. The nano-enzyme bactericide of the present invention is a two-dimensional sheet-like quasi-MOFs material derived from bimetallic organic frameworks through low-temperature oxidation, which has biological enzyme-like catalytic activity. At the same time, low-temperature oxidation maintains the structural characteristics of MOFs and improves its stability. It also enhances the electron transfer between metal sites, combined with the synergistic catalytic effect of bimetals, greatly enhances the catalytic effect of nanozymes, and achieves the purpose of efficient sterilization.

Description

technical field [0001] The invention belongs to the field of food sterilization, in particular to a nano-enzyme bactericide based on a bimetallic organic framework and a preparation method and application thereof. Background technique [0002] Foodborne pathogenic infections have become a worldwide healthcare problem due to high morbidity and mortality. Food-borne pathogens often exist in nutrient-rich foods such as bread, leftovers, and milk. Ingestion or infection by the human body usually causes food poisoning, skin ulceration, decreased immune system function and other hazards, and even leads to meningeal inflammation in severe cases. and shock. Foodborne pathogenic infections have become one of the greatest threats to global public health, afflicting millions of people each year while causing severe economic losses. [0003] Many traditional and effective sterilization methods have been widely used for the inhibition of foodborne pathogens, such as chemical disinfecta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J31/22A01N59/00A01P1/00
CPCA01N59/00B01J31/1691B01J2531/0219B01J2531/16B01J2531/38
Inventor 孙大文黄伦杰周希艺蒲洪彬
Owner SOUTH CHINA UNIV OF TECH
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