A kind of hydrophilic polyurethane foam dressing and preparation method thereof

A hydrophilic polyurethane and foam technology, applied in bandages, absorbent pads, medical science and other directions, can solve the problems of unsustainable hydrophilicity of polyurethane foam dressings, reduced mechanical properties, weak binding effect, etc., to achieve abundant reserves and reduce production. Cost, low cost effect

Active Publication Date: 2022-03-01
WUHAN RUIFA MEDICAL DEVICES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The above-mentioned polyurethane foam dressings all improve their hydrophilicity by adding hyaluronic acid or sodium alginate to the polyurethane prepolymer, but due to the relatively weak binding effect between the added hyaluronic acid or sodium alginate and the polyurethane prepolymer Weak, it is easy to lose during actual use, making it difficult to sustain the hydrophilicity of polyurethane foam dressings, and reducing its mechanical properties, resulting in limited application
In addition, the polyols currently used in the production of polyurethane foam dressings are mainly petroleum-based polyols. Since such polyols usually have problems such as high cost, difficulty in degradation, and environmental pollution, how to use cheaper and environmentally friendly vegetable oil-based polyols? Alcohol replacement has gradually become a current research hotspot

Method used

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  • A kind of hydrophilic polyurethane foam dressing and preparation method thereof
  • A kind of hydrophilic polyurethane foam dressing and preparation method thereof
  • A kind of hydrophilic polyurethane foam dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0027] The invention provides a kind of preparation method of hydrophilic polyurethane foam dressing, comprises the steps:

[0028] S1. Mix vegetable oil-based polyol and polyethylene glycol uniformly according to a preset mass ratio to obtain a polyol mixture; then add a predetermined amount of foaming agent, catalyst, surfactant and filler to the polyol mixture, After heating, stirring and fully mixing, the mixed solution I was obtained;

[0029] S2. The mixed solution I obtained in step S1 is left to stand, and after the air bubbles are removed, polyisocyanate is added according to the preset isocyanate index, and the mixed solution II is obtained after stirring rapidly to make it evenly mixed; II is poured into the mold, and after fully reacting, aging treatment is carried out to obtain a hydrophilic polyurethane foam dressing.

[0030] In step S1, the preset mass ratio of the vegetable oil-based polyol to polyethylene glycol is 1:(0.8-1.2).

[0031] In step S1, the fill...

Embodiment 1

[0041] Embodiment 1 provides a kind of preparation method of hydrophilic polyurethane foam dressing, comprises the steps:

[0042] S1. Weigh 35g of soybean oil-based polyol and polyethylene glycol according to the mass ratio of 1:1, place them in a clean plastic cup, and mix them uniformly to obtain a polyol mixture; then weigh 1.68g of distilled water (foaming agent ), 0.7g triethylenediamine (catalyst), 0.7g silicone oil (surfactant) and 0.07g sodium hyaluronate (filler), mix them uniformly and add them to the polyol mixture, at 65°C Stir for 5 min to make it evenly mixed to obtain the mixed solution I.

[0043] S2. The mixed solution I obtained in step S1 was left to stand for 2 minutes to remove air bubbles, and then calculated according to the isocyanate index of 1.2 and weighed 37.95g polyisocyanate, which was composed of 80% 2,6-toluene diisocyanate and 20 % of 4,4'-diphenylmethane diisocyanate; after adding the polyisocyanate into the mixed solution I, stir rapidly at...

Embodiment 2～3 and comparative example 2

[0051] Embodiments 2 to 3 and Comparative Example 2 respectively provide a method for preparing a hydrophilic polyurethane foam dressing. Compared with Example 1, the difference is that the amount of sodium hyaluronate used as a filler in step S1 is changed , the specific sodium hyaluronate addition amount corresponding to each embodiment and comparative example and its mass percentage in the polyol mixture are shown in Table 1; the rest of the steps are the same as in Example 1, and will not be repeated here.

[0052] Table 1 The amount of sodium hyaluronate added and its proportion in Examples 2 to 3 and Comparative Example 2

[0053]

[0054] In order to further evaluate the performance of the hydrophilic polyurethane foam dressings prepared in the above examples and comparative examples, the apparent density, water absorption rate and moisture retention were tested respectively, and the results are shown in Table 2.

[0055] The performance parameter of table 2 embodime...

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Abstract

The invention discloses a hydrophilic polyurethane foam dressing and a preparation method thereof. By mixing vegetable oil-based polyols and polyethylene glycol in proportion, adding fillers and additives, and then adding polyisocyanate for reaction after mixing evenly, the prepared product has good biocompatibility, high bioadhesion, safety and non-toxicity. Hydrophilic polyurethane foam dressing with strong hydrophilicity and long-lasting moisturizing effect. Through the above method, the present invention can make use of the mixing of vegetable oil-based polyols and polyethylene glycol to achieve suitable hydrophilicity of the polyurethane foam dressing under low-cost conditions; it can also make full use of the excellent hydrophilicity of fillers And its combined effect can improve the mechanical properties of the polyurethane foam dressing while avoiding the loss of the filler and achieve the effect of long-term moisturizing. At the same time, the overall preparation process of the hydrophilic polyurethane foam dressing provided by the invention is simple in technology and low in cost, and can meet the needs of large-scale industrial production.

Description

technical field [0001] The invention relates to the technical field of medical dressings, in particular to a hydrophilic polyurethane foam dressing and a preparation method thereof. Background technique [0002] As the largest organ of the human body, the skin plays an important role in sensing external stimuli, regulating body temperature, regulating water evaporation loss, protecting various tissues and organs in the body from physical and chemical damage, and resisting the invasion of pathogenic microorganisms. When the skin is damaged in a large area, it will cause many local or even systemic problems, and even life-threatening serious ones. Therefore, in the case of large-area defects or difficult healing in the skin, it is extremely important to cover the surface with medical dressings for repair. [0003] Medical dressings are medical and hygienic materials used to temporarily cover various wounds and wound surfaces. They can be used as temporary substitutes for skin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/66C08G18/65C08G18/64C08G18/48C08G18/36A61L15/26A61L15/42C08G101/00
CPCC08G18/6696C08G18/6547C08G18/6484C08G18/4833C08G18/4081C08G18/36A61L15/425A61L15/42A61L15/26C08L75/14
Inventor 余曾成张磊王业富
Owner WUHAN RUIFA MEDICAL DEVICES CO LTD
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