Hemostatic gel for nursing and preparation method thereof

A technology of hemostatic gel and gelatin, which is applied in the fields of medical formula, medical science, bandages, etc., can solve the problems of increasing medical expenses and achieve good hemostasis effect, anti-wound infection effect, and safe and non-toxic raw materials

Active Publication Date: 2020-10-23
MUDANJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the improvement of health care and care level, the cost of medical expenses has also increased significantly, and there is currently no ideal hemostatic agent or hemostatic gel

Method used

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  • Hemostatic gel for nursing and preparation method thereof
  • Hemostatic gel for nursing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A hemostatic gel for nursing, which contains the following components in percentage by weight: 4% carboxymethyl chitosan, 3% paeoniflorin, 1.5% fly maggot antimicrobial peptide, 1% nano-zinc oxide, 3% glycerin, tara Glue 7%, sodium carboxymethyl cellulose 7%, gelatin 20%, purified water balance.

[0028] The preparation method of described nursing hemostatic gel, comprises the steps:

[0029] (1) take each component by weight ratio;

[0030] (2) Mix carboxymethyl chitosan, glycerin, tara gum, sodium carboxymethyl cellulose, gelatin and purified water, heat in a water bath to 80-90°C, stir evenly until completely dissolved, then cool to room temperature, obtain a gel base;

[0031] (3) Add paeoniflorin, fly maggot antimicrobial peptide and nano-zinc oxide into the gel base material, mix uniformly, carry out vacuum defoaming, ultrasonically vibrate for 1-2 hours, and obtain the nursing hemostasis after irradiation sterilization gel.

Embodiment 2

[0033] A hemostatic gel for nursing, which contains the following components in weight percent: carboxymethyl chitosan 2%, paeoniflorin 5%, antibacterial peptide 0.5%, nano-zinc oxide 2%, glycerin 4%, tara gum 5% %, sodium carboxymethylcellulose 5%, gelatin 30%, the balance of purified water.

[0034] The preparation method of the hemostatic gel for nursing is the same as that in Example 1.

Embodiment 3

[0036] A hemostatic gel for nursing, which is characterized in that it contains the following components in weight percentage: carboxymethyl chitosan 6%, paeoniflorin 1%, antibacterial peptide 2%, nano-zinc oxide 1%, glycerin 2%, sting 10% pea gum, 10% sodium carboxymethylcellulose, 10% gelatin, and the balance of purified water.

[0037] The preparation method of the hemostatic gel for nursing is the same as that in Example 1.

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Abstract

The invention belongs to the field of biomedical materials, and particularly relates to hemostatic gel for nursing and a preparation method thereof. Carboxymethyl chitosan and paeoniflorin with a hemostatic effect and antibacterial peptide and zinc oxide with a bacteriostatic effect are used as active ingredients and are matched with gel matrix materials such as phaseolus vulgaris gum, sodium carboxymethyl cellulose and gelatin to prepare the hemostatic gel for nursing. The hemostatic gel for nursing has a good sealing effect on wounds, can quickly activate blood platelets, enables blood to becoagulated in a short time, and has a very good hemostatic effect and a very good wound infection prevention effect. The hemostatic gel for nursing is suitable for various types of patients, can meetthe requirements of different clinical scenes, and has positive clinical medical significance.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a nursing hemostatic gel and a preparation method thereof. Background technique [0002] When accidental trauma occurs, the human body has a spontaneous blood coagulation mechanism to reduce bleeding and reduce body damage. The normal blood coagulation of the human body depends on the contraction of the blood vessel wall, initiates a series of complex biochemical and cell biological reactions, and finally forms a blood clot to complete blood coagulation. Blood circulates and exchanges throughout the body. When the blood volume loss of the wounded reaches 20%, about 800ml, the symptoms of shock may occur, and even life-threatening. [0003] With the frequent occurrence of unstable factors such as natural disasters and the increasing incidents of accidental injuries, people's demand for rapid hemostasis materials has also increased sharply. Hemostatic materials ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0066A61L26/0038A61L26/0023A61L2300/10A61L2300/23A61L2300/252A61L2300/404A61L2300/418A61L2300/45A61L2400/04C08L89/00C08L5/08C08L1/286C08L5/00
Inventor 王久英李欣王珺周杰安烜玉韩鹏飞
Owner MUDANJIANG MEDICAL UNIV
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