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Method for extracting and purifying cannabidiol in cannabis sativa

A cannabidiol and cannabis technology, which is applied in the field of extracting and purifying cannabidiol, can solve the problems of low purity of cannabidiol, large investment, and difficulty in completely removing tetrahydrocannabinol.

Pending Publication Date: 2020-10-23
ZHEJIANG SHUANGZI INTELLIGENT EQUIP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This also makes it difficult to completely distinguish THC from cannabidiol using conventional methods, and it is difficult to completely remove THC from cannabidiol products
Therefore, in order to obtain high-purity cannabidiol, the commonly used extraction methods include carbon dioxide supercritical extraction, nitrogen supercritical extraction, and organic solvent extraction, and combined with heating or ultrasonic operations for mixed extraction, but such commonly used extraction methods Method Due to the complex composition of cannabinoids and many components with similar polarities, the purity of cannabidiol in the final product is not high. Therefore, in order to improve the extraction purity of cannabidiol, relevant research has been further deepened
[0006] The invention patent "A method of extracting cannabidiol from industrial hemp flowers and leaves" (patent application number: 201610674119.6) discloses the process of preparing cannabidiol from industrial hemp as raw material. Although this method can reduce the waste of raw material hemp, Simplify the process flow, but there are still three problems as follows: incomplete decarboxylation of raw materials leads to impure products, large equipment volume, large investment, large floor area, low efficiency, and high cost; the extraction method is a static gap method, which is low in efficiency and difficult Realize large-scale production; THC is completely separated from cannabidiol, and it is difficult to completely remove THC from cannabidiol products

Method used

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  • Method for extracting and purifying cannabidiol in cannabis sativa
  • Method for extracting and purifying cannabidiol in cannabis sativa
  • Method for extracting and purifying cannabidiol in cannabis sativa

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The marijuana leaves and flowers are harvested, dried at a temperature of 80°C until the water content is 5%, and the materials are crushed to 60 mesh to obtain clean materials for use.

[0052] Weigh 60kg of clean material, and feed it continuously into the continuous countercurrent extraction equipment (model ND50-1000) according to the feed rate of 15kg / h. The solvent is extracted with ethanol solution to obtain a crude extract, in which the ethanol solution is continuously extracted at a rate of 60L / h Feed, the concentration of ethanol solution is 95%, the feed ratio of ethanol solution to clean material is 4, the extraction temperature is 40°C, and the extraction time is 60 minutes.

[0053] The obtained crude extract is concentrated in a vacuum low-temperature concentrator at a concentration temperature of 50°C to a solid content of 15%, and then frozen and winterized to remove impurities. The winterization temperature is -65°C and the winterization time is 8 hours...

Embodiment 2

[0061] The marijuana leaves and flowers are harvested, dried at a temperature of 150°C to a water content of 3%, and the materials are crushed to 20 meshes to obtain clean materials for use.

[0062] Weigh 60kg of clean material, and feed it continuously into the continuous countercurrent extraction equipment (model ND50-1000) at a feed rate of 15kg / h. The solvent is extracted with ethanol solution to obtain a crude extract. The ethanol solution is continuously extracted at a rate of 90L / h. Feed, the concentration of ethanol solution is 60%, the feed ratio of ethanol solution to clean material is 6, the extraction temperature is 20°C, and the extraction time is 120 minutes.

[0063] The obtained crude extract is concentrated in a vacuum low-temperature concentrator at a concentration temperature of 70°C to a solid content of 10%, then frozen and winterized to remove impurities. The winterization temperature is -20°C and the winterization time is 20 hours. During the freezing pr...

Embodiment 3

[0070] The marijuana leaves and flowers are harvested, dried at a temperature of 100°C to a water content of 1%, and the materials are crushed to 80 meshes to obtain clean materials for use.

[0071] Weigh 60kg of clean material, and feed it continuously into the continuous countercurrent extraction equipment (model ND50-1000) according to the feed rate of 15kg / h. The solvent is extracted with ethanol solution to obtain a crude extract, in which the ethanol solution is continuously Feed, the concentration of ethanol solution is 90%, the feed ratio of ethanol solution to clean material is 20, the extraction temperature is 30°C, and the extraction time is 30 minutes.

[0072] The obtained crude extract is concentrated in a vacuum low-temperature concentrator at a concentration temperature of 60°C to a solid content of 15%, then frozen and winterized to remove impurities. The winterization temperature is -80°C and the winterization time is 5 hours. During the freezing process, imp...

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Abstract

The invention discloses a method for extracting and purifying cannabidiol in cannabis sativa, belonging to the field of chemical extraction and purification. The method comprises the following steps:harvesting, drying and crushing cannabis sativa leaves to obtain a clean material for later use; carrying out continuous countercurrent extraction on the clean material by adopting an ethanol solutionto obtain a crude extract; concentrating the crude extract, and conducting winterizing to remove impurities so as to obtain a winterized mixed solution; filtering the winterized mixed solution, heating the solution to 130-150 DEG C, and decarboxylating the solution for 1-2 hours to obtain a decarboxylated solution; carrying out column chromatography on the decarboxylation solution by using an ethanol solution to realize impurity removal, and conducting eluting by using the ethanol solution to obtain an eluent; concentrating the eluent to obtain an extract; supersaturating and dissolving the extract with a solvent, and then carrying out cooling to -30 DEG C to -10 DEG C to obtain a crystal substance; and washing the crystal substance with solvent, draining the crystal substance and then carrying out drying to obtain cannabidiol. According to the method, a decarboxylation degree is complete, the purity of cannabidiol is high, and tetrahydrocannabinol (THC) is almost not contained.

Description

technical field [0001] The invention belongs to the field of chemical extraction and purification, in particular to a method for extracting and purifying cannabidiol from cannabis. Background technique [0002] Cannabis scientific name Cannabis, Cannabis genus, also known as hemp, hemp, hemp, mountain silk seedling, jute, has important agricultural and medicinal value. Marijuana contains a toxic component, tetrahydrocannabinol, which can make people hallucinogenic and addictive, and can be used as a drug. It was banned for a long time. [0003] Due to the high economic and medicinal value of cannabis, the raw material cannabis for industrial use is referred to as "industrial hemp". The value of hydrocannabinol may be taken directly as a drug, and it can be legally carried out in large-scale cultivation and industrial development and utilization. [0004] Cannabidiol contained in cannabis is a phenolic compound that has not been isolated from other animals and plants. Canna...

Claims

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Application Information

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IPC IPC(8): C07C39/23C07C37/68C07C37/82C07C37/84C07C37/70C07C37/50
CPCC07C37/685C07C37/82C07C37/84C07C37/70C07C37/50C07C2601/16C07C39/23
Inventor 田汉玉郑明辉郑植标罗飞叶彬康浦
Owner ZHEJIANG SHUANGZI INTELLIGENT EQUIP CO LTD
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