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Material surface modification method, modified material and application thereof, and medical product

A surface modification and product technology, applied in the direction of microorganism-based methods, biochemical equipment and methods, bone/connective tissue cells, etc., can solve the problems of long time, inability to simultaneously regulate physical and chemical properties, and high cost

Active Publication Date: 2020-10-30
SHENZHEN INST OF ADVANCED TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lithographic printing technology can construct surface physical and chemical properties with high precision, but due to the long time required and high cost, it is greatly constrained in the application of large-area surface modification
[0004] In addition, the existing technology cannot realize the simultaneous regulation of the physical and chemical properties of the material surface. The common method is to first construct the physical structure and then carry out the next step of chemical modification on the surface with the physical structure, and the existing chemical modification methods are mostly surface Uniform modification, although it is possible to achieve multiple chemical regional modifications on the surface through the method of occlusion-modification-de-occlusion, but this method also requires at least three or more steps to achieve

Method used

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  • Material surface modification method, modified material and application thereof, and medical product
  • Material surface modification method, modified material and application thereof, and medical product
  • Material surface modification method, modified material and application thereof, and medical product

Examples

Experimental program
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Embodiment approach

[0072] For example, in one embodiment, the inorganic colloidal particles are one kind (such as SiO 2 microspheres), then SiO 2 The same type of chemically modified SiO can be included in the microspheres 2 Microspheres (such as SiO 2 -X), can also contain many different kinds of chemically modified SiO 2 Microspheres (such as SiO 2 -X, SiO 2 -Y, SiO 2 Any combination of two or more of -Z, etc.), wherein X, Y, and Z represent different modifying groups.

[0073] For example, in another embodiment, the inorganic colloidal particles are several types (such as SiO 2 Microspheres and TiO 2 combination of microspheres), then SiO 2 Microspheres and TiO 2 Microspheres can contain the same type of chemically modified SiO 2 Microspheres (such as SiO 2 -X) and / or TiO 2 Microspheres (such as TiO 2 -X), can also contain many different kinds of chemically modified SiO 2 Microspheres and / or TiO 2 Microspheres (such as SiO 2 -X, SiO 2 -Y, SiO 2 -Z, TiO 2 -X 1 、TiO 2 -Y 2...

Embodiment 1

[0117] Example 1 Preparation of SiO with a particle size of 5 μm 2 -NH 2 , SiO 2 -Epoxy (silica microspheres with glycidyl groups on the surface), SiO 2 -RGD, SiO 2 -Br and SiO with a particle size of 5 μm 2 -SBMA

[0118] (1) 50 mg of SiO with a particle size of 5 μm 2Add spheres and 5mL anhydrous tetrahydrofuran (THF) into a round-bottomed flask, and disperse the microsphere particles to form a uniform suspension by repeated ultrasonication and vibration; add 200μL 3-aminopropyltrimethoxysilane under stable stirring of the suspension , and kept stirring for 24 hours; after the reaction, the mixture was transferred to a centrifuge tube to collect the microspheres by centrifugation, the microspheres were washed three times with THF and alcohol respectively, and then heated to 100 ° C for 3 hours to obtain SiO 2 -NH 2 ;

[0119] (2) 50 mg of SiO with a particle size of 5 μm 2 Add the balls and 5 mL of anhydrous THF into a round bottom flask, and disperse the microspher...

Embodiment 2

[0123] Example 2 Preparation of SiO with a particle size of 2 μm 2 -Br and SiO with a particle size of 2 μm 2 -SBMA

[0124] Step (1) uses SiO with a particle size of 2 μm 2 Ball, all the other steps are identical with embodiment 1.

[0125] The colloidal particles SiO synthesized by embodiment 1 and embodiment 2 2 -NH 2 , SiO 2 -Br and SiO 2 -SBMA were verified by XPS scanning, and the results are shown in Table 1.

[0126] Table 1 XPS element scanning results (atom%)

[0127]

[0128] The results in Table 1 show that, compared to SiO 2 , SiO 2 -NH 2 The appearance of nitrogen in the sample can prove the successful grafting of amino groups; SiO 2 -Epoxy samples compared to SiO 2 The increase in the ratio of sample carbon to oxygen proves the access of a small amount of epoxy groups (tested SiO 2 The ratio of carbon to oxygen is 0.16, SiO 2 -Epoxy is 0.47, and the ratio of the two elements in the epoxy monomer is 2.4, which proves that a small amount of epoxy ...

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Abstract

The invention discloses a material surface modification method, a modified material and application thereof, and a medical product, and relates to the technical field of material surface modification.The surface modification method of the material comprises the following steps: forming a coating on the surface of the material through a colloidal particle self-assembly method, wherein the colloidal particles comprise inorganic colloidal particles with the particle size of 1-10 [mu] m and organic polymer colloidal particles with the particle size of 0.05-0.75 [mu] m, all or part of the inorganic colloidal particles are subjected to chemical modification, and the chemical modification comprises chemical functional group modification and / or bioactive molecule modification. According to the invention, chemical modification and self-assembly of colloidal particles are combined, physical and chemical properties of the surface of the material can be regulated and controlled at the same time,regional diversity of surface chemistry can be achieved by selecting colloid particles with different chemical modifications for self-assembly, the method is simple and rapid, and the surface with a multi-stage physical structure and complex chemistry can be constructed in a large area in one step.

Description

technical field [0001] The invention relates to the technical field of surface modification of materials, in particular to a method for surface modification of materials, modified materials and applications, and medical products. Background technique [0002] The surface modification technology of materials has a wide range of applications, including medical devices or industrial anti-corrosion and other fields. Modifications to the surface of materials can be divided into two categories: changes in physical structure and changes in chemical properties. Methods of altering the physical structure of the surface include etching, lithography or reprinting techniques. Methods for changing surface chemical properties include layer by layer, targeted reactions based on surface chemical functional groups, and non-specific coatings on the surface of materials (substrate independent coating). [0003] The existing process of changing the controllable physical structure or chemical ...

Claims

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Application Information

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IPC IPC(8): C09D1/00C09D125/06C09D133/12C12N1/20C12N5/077C12R1/385C12R1/19
CPCC09D1/00C09D125/06C09D133/12C12N1/20C12N5/0654C12N2537/00C12N2533/20C12N2533/40C12N2533/30
Inventor 王鹏元石玥陶雪莲彼特·金肖特赫尔穆特·泰森
Owner SHENZHEN INST OF ADVANCED TECH
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