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Preparation method of rare earth upconversion nanoparticle/bismuth vanadate nano composite material with antitumor effect

A nanocomposite material, rare earth upconversion technology, applied in the field of synthesis of anti-tumor nanomaterials, can solve problems such as large size and limitation

Active Publication Date: 2020-11-06
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The present invention will solve the BiVO synthesized by existing methods 4 The larger size limits its application in the biomedical field, and a preparation method for rare earth up-conversion nanoparticles / bismuth vanadate nanocomposites with anti-tumor effects is provided. At the same time, the use of up-conversion nanoparticles to nearly The absorption of infrared light and the effect on BiVO 4 The secondary excitation function of the crystal realizes the photodynamic therapy under the irradiation of near-infrared light

Method used

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  • Preparation method of rare earth upconversion nanoparticle/bismuth vanadate nano composite material with antitumor effect
  • Preparation method of rare earth upconversion nanoparticle/bismuth vanadate nano composite material with antitumor effect
  • Preparation method of rare earth upconversion nanoparticle/bismuth vanadate nano composite material with antitumor effect

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specific Embodiment approach 1

[0096] Specific embodiment one: present embodiment a kind of preparation method of rare earth up-conversion nanoparticles / bismuth vanadate nanocomposite material with anti-tumor effect, it is carried out according to the following steps:

[0097] 1. Preparation of synthetic core-structured nanoparticles:

[0098] ①. Add yttrium source, ytterbium source and thulium source into water respectively to obtain yttrium source aqueous solution, ytterbium source aqueous solution and thulium source aqueous solution respectively, and then mix the yttrium source aqueous solution, ytterbium source aqueous solution and thulium source aqueous solution to obtain yttrium source, ytterbium source aqueous solution and thulium source aqueous solution. A mixed solution of thulium source and thulium source;

[0099] The concentration of the yttrium source in the mixed solution of the yttrium source, the ytterbium source and the thulium source is 0.13g / mL~0.15g / mL; the concentration of the ytterbium...

specific Embodiment approach 2

[0160] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the yttrium source described in step one 1. is yttrium chloride; the ytterbium source described in step one 1. is ytterbium chloride; The thulium source described is thulium chloride; the inorganic fluoride described in step 1.3 is NH 4 F; The sodium source described in step 1.3. is NaOH. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0161] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is: the centrifugal washing described in step 14 is specifically under the condition that the centrifugal rate is 4000 rpm to 10000 rpm, first Centrifuge with ethanol to get the precipitate, then centrifuge with cyclohexane to get the supernatant, then centrifuge with ethanol to get the precipitate. Others are the same as in the first or second embodiment.

[0162] In this embodiment, the product is successively extracted with ethanol and cyclohexane and centrifuged to remove impurities to purify and separate the product.

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Abstract

The invention discloses a preparation method of a rare earth upconversion nanoparticle / bismuth vanadate nano composite material with an antitumor effect, and relates to a synthesis method of an antitumor nano material. The invention aims to solve the problems that BiVO4 synthesized by the existing method is large in size and the application of BiVO4 in the field of biomedicine is limited. The preparation method comprises the following steps: 1, preparing synthetic core structure nanoparticles; 2, synthesizing core-shell structure nanoparticles; 3, preparing hydrophilic up-conversion nanoparticles; 4, synthesizing zinc nitrophthalocyanine; 5, synthesizing amino zinc phthalocyanine; 6, synthesizing a BiVO4 nanosheet by a high-temperature pyrolysis method; 7, connecting UCNPs with zinc aminophthalocyanine; and 8, preparing and modifying the composite material PVP / UCNPs-ZnPc@BiVO4. The preparation method is used for preparing the rare earth upconversion nanoparticle / bismuth vanadate nano composite material with the antitumor effect.

Description

technical field [0001] The invention relates to a synthesis method of an anti-tumor nanometer material. Background technique [0002] Cancer treatment has become an important global problem. In recent years, the development and application of photodynamic therapy technology has gradually become one of the important research goals in the field of tumor treatment. Studies have shown that the effect of photodynamic therapy can be effectively improved by selecting a suitable light source and photosensitizer. Traditional inorganic and organic photosensitizers have some disadvantages that limit their applications, such as high toxicity, poor water solubility, and visible light absorption. The application of lanthanide-doped up-conversion nanomaterials to near-infrared light-excited photodynamics can solve the above problems. Near-infrared light-excited photodynamic therapy has unique advantages. First, near-infrared light with a wavelength of 980nm is used as an excitation light...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/06C09K11/85C09K11/83B82Y30/00B82Y40/00A61K41/00A61P35/00
CPCA61K41/0057A61P35/00B82Y30/00B82Y40/00C09K11/025C09K11/06C09K11/7773C09K11/7776
Inventor 贺飞李思怡杨飘萍朱辉盖世丽
Owner HARBIN ENG UNIV
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