Raman substrate for respiratory virus detection as well as preparation method and application thereof

Abstract

The invention discloses a surface-enhanced Raman substrate for rapid detection of respiratory viruses. The surface-enhanced Raman substrate comprises a flexible substrate layer composed of a flexiblesubstrate material, the surface of the flexible substrate material being loaded with noble metal particles; the preparation method comprises the following steps: preparing a seed particle dispersion,preparing AgNPs, preparing an Au growth solution, preparing Ag@AuNPs, and dispensing the Ag@AuNPs on a flexible substrate to prepare a surface-enhanced Raman substrate.

Description

technical field [0001] The invention relates to the technical field of virus detection and nanomaterials, and more specifically relates to a Raman substrate for respiratory virus detection and its preparation method and application. Background technique [0002] Respiratory virus refers to the general term for viruses that use the respiratory tract as the portal to invade and cause local infection of the respiratory tract or lesions of tissues and organs other than the respiratory tract due to the proliferation of skin cells on the respiratory mucosa. Common respiratory viruses include influenza virus, parainfluenza virus, respiratory syncytial virus, adenovirus, rhinovirus, coronavirus, etc. 90-95% of clinical acute respiratory infections are caused by these viruses. [0003] There are many types of pathogens that cause respiratory tract infections, and the degree of harm varies, but most patients have similar initial clinical symptoms after infection, which mainly endanger...

AI Technical Summary

Problems solved by technology

Combining the above diagnostic methods can basically realize the diagnosis of pathogens, but there are still shortcomings such as long detection time, high risk of sampling infection, low accuracy rate, high technical requirements for analysts, and invasive detection.

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