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Microneedle patch and preparation method thereof

A micro-needle sticker and micro-needle technology, applied in the fields of biomedicine and medical cosmetology, can solve the problems of rapid degradation and painful insertion into the skin, and achieve the effect of improving degradation performance and facilitating the hardness of micro-needles.

Pending Publication Date: 2020-11-10
李媚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, microneedles degrade too quickly during use and cause pain when inserted into the skin, and there are very few related reports or studies

Method used

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  • Microneedle patch and preparation method thereof
  • Microneedle patch and preparation method thereof
  • Microneedle patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Example 1: Comparison of microneedle degradation performance

[0065] In this experiment, the degradation performance and hardness of the microneedles were compared. The pH of the microneedles was 7.2. The diameter of the microneedles containing cross-linked sodium hyaluronate was 300 μm, the height was 0.25 mm, the distance between the microneedles was 0.3 mm, and the diameter of the needle tip was 10 μm. The cross-linking degree of sodium hyaluronate is 2%, the residual cross-linking agent is 1 ppm, and the performance parameters related to the microneedles are shown in Table 1.

[0066] Degradation performance is expressed as residual percentage (%): 300 mg of microneedles are put into a 1 ml centrifuge tube, 1 ml of water for injection is added, and after thorough mixing, hyaluronidase is added to each tube at a concentration of 30 IU / ml. The sample without enzyme addition and other operations kept the same as the control. 37 ℃ constant temperature for half an hour...

Embodiment 2

[0070] Example 2: Comparison of microneedle degradation performance

[0071]In this experiment, the degradation performance and hardness of the microneedles were compared. The pH of the microneedles was 7.5, the diameter of the microneedles containing cross-linked collagen was 500 μm, the height was 0.2 mm, the distance between the microneedles was 0.5 mm, the diameter of the needle tip was 10 μm, and the cross-linking agent remained. is 2ppm, and the performance parameters related to the microneedle are shown in Table 2.

[0072] Degradation performance was expressed as residual percentage (%): 300 mg of microneedles were put into a 1 ml centrifuge tube, 1 ml of water for injection was added, and after thorough mixing, collagenase was added to each tube at a concentration of 20 IU / ml. The sample without enzyme addition and other operations kept the same as the control. 37 ℃ constant temperature for half an hour. After the reaction, each tube was centrifuged, the supernatant...

Embodiment 3

[0076] Example 3: Performance comparison of microneedles

[0077] In this experiment, the applicant further comparatively studied the hardness and experience of the microneedles in Example 1 and Example 2, and the result parameters are shown in Table 3.

[0078] Hardness test method: insert the needle tip of the microneedle into a rubber with a thickness of 2.5 mm, and the insertion speed is 6 mm / s, and measure the maximum force when inserting the rubber, which is the hardness of the microneedle. The greater the insertion force, the higher the hardness.

[0079] Experience test method: subjective judgment when inserting into the skin, 0 points for no pain, 1 point for general pain, 2 points for pain, 3 points for very pain, and 4 points for unacceptable pain.

[0080] table 3.

[0081] Numbering Hardness (N) experience score 1-1 0.312 1 1-2 0.328 1 1-3 0.354 1 1-4 0.373 1 1-5 0.394 1 1-6 0.395 1 1-7 0.493 2 2-1 0.3...

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Abstract

The invention relates to a microneedle patch and a preparation method thereof, in particular to a biodegradable microneedle patch inserted into the skin painlessly. The microneedle patch is characterized in that a microneedle contains a certain proportion of cross-linked sodium hyaluronate or / and cross-linked collagen and a certain analgesic material, so that the technical problems of long-actingslow release of the microneedle, pain during insertion and hardness are solved; and the microneedle patch can be used in the fields of biomedicine, medical cosmetology and the like.

Description

technical field [0001] The invention relates to a micro-needle patch and a preparation method thereof, in particular to a biodegradable micro-needle patch inserted into human skin, which can be used in the fields of biomedicine, medical cosmetology and the like. Background technique [0002] In the field of biomedicine and medical cosmetology, traditional oral administration, subcutaneous injection administration, and transdermal patch administration are the most common administration methods. Oral administration is simple, convenient and the most common, but drug absorption is affected by gastrointestinal function, and some drugs can have adverse irritating effects on the gastrointestinal tract; subcutaneous injection is a transdermal (transdermal) administration method, although it breaks through the stratum corneum However, its biggest disadvantage is that it will cause pain, bacterial infection, tissue damage, etc. to the human body, and even the adverse consequences of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K9/00A61K47/36A61K47/42A61K8/02A61K8/73A61K8/65A61Q19/00A61M37/00
CPCA61K9/7023A61K9/0021A61K47/36A61K47/42A61K8/0208A61K8/735A61K8/65A61Q19/00A61M37/0015A61K2800/10A61M2037/0023A61M2037/0053
Inventor 李媚
Owner 李媚
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