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Biological polysaccharide with effect of preventing and treating hormone dependent dermatitis and application of biological polysaccharide

A technology for dependent dermatitis and hormones, applied in skin care preparations, anti-inflammatory agents, drug combinations, etc., can solve the problems of long treatment cycle, difficult to cure, stay, etc., and achieve the effect of good water solubility

Pending Publication Date: 2020-11-24
ZHEJIANG GLLION BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the incidence of hormone-dependent dermatitis has an obvious upward trend, and it is stubborn and difficult to cure
At present, the commonly used treatment methods stay on moisturizing, anti-inflammatory, anti-allergic and anti-infective treatments. The treatment cycle is long, the effect is poor, and it is easy to relapse, which brings double trauma to the patient's physiology and psychology.

Method used

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  • Biological polysaccharide with effect of preventing and treating hormone dependent dermatitis and application of biological polysaccharide
  • Biological polysaccharide with effect of preventing and treating hormone dependent dermatitis and application of biological polysaccharide
  • Biological polysaccharide with effect of preventing and treating hormone dependent dermatitis and application of biological polysaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0193] Example 1, the acquisition and determination of β-glucan

[0194] This example only takes the β-glucan obtained by fermentation of Schizophyllum as an example, but is not limited thereto.

[0195] 1. Obtaining the fermentation broth of Schizophyllum strains

[0196] The fermented liquid in the following examples is passed through fermentation Schizophyllum strain (Schizophyllum commune Fr-1003, catalogue: 38548 TM , purchased from the American Type Culture Collection [ATCC]), the details are as follows:

[0197] 1. Activation of Schizophyllum strains: 200g / L of potatoes, 30g / L of glucose, 10g / L of sodium chloride, and 20g / L of agar are made into a plate medium, and the strains of Schizophyllum are inoculated on the plate medium , cultured in a constant temperature incubator at 25°C for 7 days to obtain plate mycelium;

[0198] 2. Seed activation: put potato starch 100g / L, glucose 40g / L, yeast extract 2g / L, yeast extract powder 2g / L, and water into a shaker flask, a...

Embodiment 2

[0250] Example 2, Therapeutic effect of β-glucan on hormone-dependent dermatitis

[0251] 1. Use age-appropriate guinea pigs and feed them for a week to adapt to the new environment. Feed and water are freely ingested;

[0252] 2. After one week of feeding, remove the hair on the back and apply 0.05% clobetasol propionate;

[0253] 3. Apply 0.05% clobetasol propionate externally every day, stop applying after about 15 days, and establish a hormone-dependent dermatitis model;

[0254] 4. According to the grouping in Table 4, β-glucan from different sources, positive therapeutic drugs, and β-glucan combined with positive therapeutic drugs were applied to the hormone-dependent dermatitis site on the back of guinea pigs twice a day;

[0255] 5. Take pictures every day to observe the treatment effect of hormone-dependent dermatitis.

[0256] Table 4 Experimental grouping of the therapeutic / preventive effect of β-glucan on hormone-dependent dermatitis

[0257]

[0258] The res...

Embodiment 3

[0259] Example 3, the preventive effect of β-glucan on hormone-dependent dermatitis

[0260] 1. Use age-appropriate guinea pigs and feed them for a week to adapt to the new environment. Feed and water are freely ingested;

[0261] 2. After one week of feeding, remove the hair on the back;

[0262] 3. According to the grouping in Table 4, β-glucan from different sources, positive therapeutic drugs, and β-glucan combined with positive therapeutic drugs were applied to the back of guinea pigs twice a day for one week;

[0263] 4. One week later, after applying the drug each time, apply 0.05% clobetasol propionate externally, twice a day;

[0264] 5. Take pictures every day to observe the preventive effect of hormone-dependent dermatitis.

[0265] The results show that the β-glucan prepared by the method in Example 1 can prevent the occurrence of hormone-dependent dermatitis, while the soluble yeast β-glucan cannot achieve the corresponding effect.

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Abstract

The invention provides a biological polysaccharide with the effect of preventing and treating hormone dependent dermatitis and an application of the biological polysaccharide. In particular, the invention provides the use of beta-glucan for the preparation of a preparation or composition for the prevention and / or treatment of hormone dependent dermatitis. The beta-glucan has the effects of obviously relieving and improving the hormone-dependent dermatitis, effectively controlling the occurrence of the hormone-dependent dermatitis and accelerating the regression of the hormone-dependent dermatitis. Meanwhile, the beta-glucan can also enhance the active defense function of the skin, resist bacteria, diminish inflammation and repair the skin, treat or prevent skin mucosa inflammation or otherskin inflammatory diseases, and improve the conditions of dry skin or red and swollen skin and the like of a patient.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a biological polysaccharide capable of preventing and treating hormone-dependent dermatitis and its application. Background technique [0002] Glucocorticoid is an extremely important class of regulatory molecules in the body. It plays an important role in regulating the development, growth, metabolism and immune function of the body. It is the most important regulatory hormone for the body's stress response and is the most widely used clinically. And effective anti-inflammatory and immunosuppressant. In emergency or critical cases, glucocorticoids are often the first choice. They have anti-inflammatory, anti-toxic, anti-allergic, anti-shock, non-specific immune suppression and antipyretic effects, and can prevent and prevent immune inflammatory reactions and pathology The occurrence of sexual immune response is effective for almost any type of allergic disease. [0003] However, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/716A61K45/06A61P17/00A61P17/02A61P29/00A61K8/73A61Q19/00C08B37/02
CPCA61K31/716A61K45/06A61P17/00A61P17/02A61P29/00A61K8/73A61Q19/00C08B37/0024A61K2300/00A61K9/14A61K47/10A61K47/14A61K47/34A61K47/36A61K9/0014A61K9/06
Inventor 郭宏亮庄秀园叶榛郭晓宇吴佳迪王轩朱勤健
Owner ZHEJIANG GLLION BIOTECH CO LTD
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