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Oral ulcer preparation containing antibacterial and healing-promoting composition

A technology for oral ulcers and compositions, applied in the field of oral ulcer preparations, can solve the problems of easy sensitization, inferior antibacterial properties, allergic symptoms, etc., and achieve the effect of promoting repair and healing, and obvious bactericidal and antibacterial effects

Active Publication Date: 2021-10-19
HARBIN QIANBAINA BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the antibacterial properties of the various compositions in the above-mentioned patents are still relatively inferior. At the same time, some raw materials such as chitin may cause allergic symptoms.
[0005] In view of the poor efficacy and allergenicity of the existing antibacterial and healing-promoting compositions, a safer antibacterial and healing-promoting composition and its corresponding preparations should be found, so that antibacterial and healing-promoting compositions can be safely and efficiently achieved. The purpose of bacteria to promote healing

Method used

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  • Oral ulcer preparation containing antibacterial and healing-promoting composition
  • Oral ulcer preparation containing antibacterial and healing-promoting composition
  • Oral ulcer preparation containing antibacterial and healing-promoting composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] An antibacterial and healing-promoting composition, comprising octenidine, chitosan derivatives and traditional Chinese medicine volatile oil clathrate, the weight ratio of the three is 1:5:5, wherein, the raw material of the traditional Chinese medicine volatile oil clathrate includes mint , Artemisia argyi and clove, the weight ratio of the three is 10:1:1.

[0063] The preparation method of above-mentioned antibacterial and healing-promoting composition comprises the following steps:

[0064] (1) extract volatile oil: take mint, mugwort leaf, clove decoction pieces in proportion, add 6 times of water, after soaking for 0.5h, extract volatile oil by steam distillation for 0.5h, collect volatile oil, set aside;

[0065] (2) Preparation of Chinese medicine volatile oil clathrate:

[0066] Weigh 3 parts of β-cyclodextrin and add 30 parts of distilled water. Heat and dissolve in a water bath, slowly add 1 part of the above-mentioned volatile oil while stirring, after st...

Embodiment 2

[0069] An antibacterial and healing-promoting composition, comprising octenidine, chitosan derivatives and traditional Chinese medicine volatile oil clathrate, the weight ratio of the three is 1:15:15, wherein, the raw material of traditional Chinese medicine volatile oil clathrate includes peppermint , Artemisia argyi and clove, the weight ratio of the three is 10:4:5.

[0070] (1) extract volatile oil: take mint, mugwort leaves, clove slices in proportion, add 15 times of water, soak for 12 hours, extract volatile oil by steam distillation for 12 hours, collect volatile oil, and set aside;

[0071] (2) Preparation of Chinese medicine volatile oil clathrate:

[0072] Weigh 15 parts of β-cyclodextrin and add 100 parts of distilled water. Heat and dissolve in a water bath, slowly add 1 part of the above-mentioned volatile oil while stirring, after stirring for 3 hours, let it stand for refrigerated for 24 hours, filter, and wash the precipitate with distilled water and ethanol...

Embodiment 3

[0075] An antibacterial and healing-promoting composition, comprising octenidine, chitosan derivatives and traditional Chinese medicine volatile oil clathrate, the weight ratio of the three is 1:15:20, wherein, the raw material of traditional Chinese medicine volatile oil clathrate includes peppermint , Artemisia argyi and clove, the weight ratio of the three is 10:3:5.

[0076] The preparation method is the same as in Example 1.

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Abstract

The invention provides an oral ulcer preparation containing a bacteriostatic and healing-promoting composition, and relates to the technical field of antibacterial medicines, wherein the raw materials of the composition include octenidine and chitosan derivatives, and the raw materials of the composition There is a synergistic effect, and the matrix can be added to make a double-layer film, gel or solution. When used in the oral ulcer site, it has good bioadhesion and can adhere well to the ulcer wound. , and make the patient feel less foreign body sensation, easy to use, has the advantages of anti-inflammatory, bactericidal and antibacterial, repairing ulcer wounds, promoting healing, etc.

Description

technical field [0001] The invention relates to the technical field of antibacterial medicines, in particular to an oral ulcer preparation containing an antibacterial and healing-promoting composition. Background technique [0002] There are microorganisms symbiotic with the host in the oral cavity, forming a tiny ecosystem with the oral environment. Under normal physiological conditions, the micro-ecosystem in the oral cavity is stable and can resist the influence of the outside world on this environment. However, when there is an oral ulcer in the oral cavity, external microorganisms infecting the wound will aggravate the inflammation and deterioration of the wound and affect daily life. Oral ulcer, commonly known as "oral sore", is a common ulcerative injury disease that occurs in the oral mucosa. It is more common in the inner lip, tongue, tongue belly, buccal mucosa, vestibular groove, soft palate and other parts. The mucosa in these parts lacks stratum corneum. or po...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61K31/7008A61K31/444A61K36/61A61K36/84A61K36/758A61P1/02A61P31/04A61P31/10
CPCA61K31/444A61K31/7008A61K31/722A61K36/282A61K36/284A61K36/532A61K36/534A61K36/54A61K36/57A61K36/61A61K36/758A61K36/84A61P1/02A61P31/04A61K2300/00
Inventor 高纳新霍东风
Owner HARBIN QIANBAINA BIOPHARM
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