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Application of pirfenidone to preparation of medicine for preventing and treating rheumatoid arthritis

A pirfenidone and rheumatoid technology, applied in the field of drugs for preventing and treating rheumatoid arthritis, can solve the problems of ineffective prevention, large side effects, single function, etc., and achieves inhibition of angiogenesis, inhibition of inflammatory response, and obvious inhibition effect of action

Pending Publication Date: 2020-11-27
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of this application is to provide an application of pirfenidone in the preparation of drugs for preventing and treating rheumatoid arthritis. big problem

Method used

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  • Application of pirfenidone to preparation of medicine for preventing and treating rheumatoid arthritis
  • Application of pirfenidone to preparation of medicine for preventing and treating rheumatoid arthritis
  • Application of pirfenidone to preparation of medicine for preventing and treating rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0109] Measurement and analysis of the improvement effect of PFD on foot swelling in CIA rats

[0110] Twenty-four male Lewis rats (8 weeks old) were raised in a pathogen-free environment. The 24 rats were randomly divided into 4 groups (6 rats / group): normal group (Normal, first group) and 3 CIA model groups (second to fourth groups). First, establish the CIA rat model: mix the same amount of bovine type II collagen and incomplete adjuvant with a glass syringe, inject 200 μl of the suspension subcutaneously at a place 2 cm from the root of the tail of the rat, and after 7 days, follow the above method, each Inject 100 μl of the suspension at the base of the tail of the mouse to strengthen the immune response, and after 14 days, it is confirmed that the modeling is successful. After the CIA model was successfully established, the mice in the second group were given carboxymethylcellulose sodium suspension, 10 ml / kg / day (CIA), and the mice in the third group were given methotr...

experiment example 2

[0113] Using hematoxylin and eosin staining to detect the effect of PFD on synovial inflammation of CIA rats

Embodiment 1

[0114] After the rats in Example 1 were euthanized, the right knee joint was fixed with 4% paraformaldehyde, decalcified with 10% EDTA for 40 days, followed by routine dehydration, paraffin embedding, and 5-μm sectioning. Then hematoxylin and eosin (H&E) staining was performed on the sections: the paraffin sections of knee joints were routinely dewaxed and rehydrated with xylene and gradient alcohol, stained with hematoxylin staining solution for 7 minutes, and the excess staining solution was rinsed before use. Stain with Yin Hong for 1 minute, then use graded alcohol to dehydrate, clear with xylene, then mount with neutral gum, and finally take pictures of the sections for analysis. The scoring criteria for joint synovial inflammation are: 0 = no inflammation, 1 = slightly thickened synovial lining or inflammatory cell infiltration, 2 = slightly thickened synovial lining with inflammatory cell infiltration, 3 = synovial lining Thickened layer, synovial space infiltration of ...

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Abstract

The application relates to the technical field of medicines, in particular to an application of pirfenidone to preparation of a medicine for preventing and treating rheumatoid arthritis and the medicine for preventing and treating rheumatoid arthritis. According to the application of the pirfenidone to preparation of the medicine for preventing and treating rheumatoid arthritis, the chemical structural formula of the pirfenidone is shown as a formula 1, or salt as shown in the formula 1. The pirfenidone can effectively restrain an RA process by restraining inflammatory reaction and restrainingkey pathologic links of vascular proliferation and the like, so that rise of inflammatory factors of interleukin 6, interleukin 8, interleukin 1 beta and the like secreted by human RA fibroblasts induced by tumor necrosis factors alpha can be notably reduced, abnormal rise of expression level of the vascular endothelial growth factors secreted by the human RA fibroblasts induced by tumor necrosisfactors alpha can be notably reduced, and the pirfenidone has obvious restraining effects on rheumatoid arthritis.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to an application of pirfenidone in the preparation of a medicine for preventing and treating rheumatoid arthritis, and a medicine for preventing and treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (Rheumatoid Arthritis, RA) is a chronic systemic disease of unknown etiology, mainly characterized by synovial hyperplasia, inflammatory cell infiltration, pannus formation, cartilage and bone damage. It is characterized by polyarticular, symmetrical, and aggressive arthritis of the small joints of the hands and feet, often accompanied by extra-articular organ involvement and positive serum rheumatoid factor, which can lead to joint deformities and loss of function. It is an autoimmune inflammatory disease. In the early stage of the disease, joints are red, swollen, hot, painful, and dysfunctional. In the late stage, the joints may appear st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4418A61P29/00A61P19/02A61P37/02
CPCA61K31/4418A61P19/02A61P29/00A61P37/02
Inventor 张鹏甘东浩成文翔柯丽青
Owner SHENZHEN INST OF ADVANCED TECH
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